Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain
Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a therapeutic tool in various neurological and psychiatric disorders, and we recently found that it has a neuroprotective effect both in vitro and in vivo. However, the neurochemical mechanisms underlying the therapeutic eff...
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| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 2000-08, Vol.23 (2), p.205-215 |
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| creator | MÜLLER, M. B TOSCHI, N KRESSE, A. E POST, A KECK, M. E |
| description | Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a therapeutic tool in various neurological and psychiatric disorders, and we recently found that it has a neuroprotective effect both in vitro and in vivo. However, the neurochemical mechanisms underlying the therapeutic effects are still unknown. We investigated the effects of long-term rTMS on the expression of brain-derived neurotrophic factor (BDNF), cholecystokinin (CCK), and neuropeptide tyrosine (NPY) mRNA in rat brain. In situ hybridization revealed a significant increase in BDNF mRNA in the hippocampal areas CA3 and CA3c, the granule cell layer, as well as in the parietal and the piriform cortex after rTMS. BDNF-like immunoreactivity was markedly increased in the same areas. A significant increase in CCK mRNA was observed in all brain regions examined. NPY mRNA expression, in contrast, was not altered. The present results suggest that BDNF may contribute to the neuroprotective effects of rTMS. Furthermore, the rTMS-induced changes in BDNF and CCK expression are similar to those reported after antidepressant drug treatment and electroconvulsive seizures, suggesting that a common molecular mechanism may underlie different antidepressant treatment strategies. |
| doi_str_mv | 10.1016/S0893-133X(00)00099-3 |
| format | Article |
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B ; TOSCHI, N ; KRESSE, A. E ; POST, A ; KECK, M. E</creator><creatorcontrib>MÜLLER, M. B ; TOSCHI, N ; KRESSE, A. E ; POST, A ; KECK, M. E</creatorcontrib><description>Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a therapeutic tool in various neurological and psychiatric disorders, and we recently found that it has a neuroprotective effect both in vitro and in vivo. However, the neurochemical mechanisms underlying the therapeutic effects are still unknown. We investigated the effects of long-term rTMS on the expression of brain-derived neurotrophic factor (BDNF), cholecystokinin (CCK), and neuropeptide tyrosine (NPY) mRNA in rat brain. In situ hybridization revealed a significant increase in BDNF mRNA in the hippocampal areas CA3 and CA3c, the granule cell layer, as well as in the parietal and the piriform cortex after rTMS. BDNF-like immunoreactivity was markedly increased in the same areas. A significant increase in CCK mRNA was observed in all brain regions examined. NPY mRNA expression, in contrast, was not altered. The present results suggest that BDNF may contribute to the neuroprotective effects of rTMS. Furthermore, the rTMS-induced changes in BDNF and CCK expression are similar to those reported after antidepressant drug treatment and electroconvulsive seizures, suggesting that a common molecular mechanism may underlie different antidepressant treatment strategies.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1016/S0893-133X(00)00099-3</identifier><identifier>PMID: 10882847</identifier><identifier>CODEN: NEROEW</identifier><language>eng</language><publisher>New York, NY: Nature Publishing</publisher><subject>Animals ; Antidepressants ; Biological and medical sciences ; Brain ; Brain - metabolism ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - biosynthesis ; Brain-Derived Neurotrophic Factor - genetics ; Cerebral Cortex - metabolism ; Cerebrospinal fluid ; Cholecystokinin - biosynthesis ; Cholecystokinin - genetics ; Convulsions & seizures ; Dentate Gyrus - metabolism ; Diseases of the nervous system ; Dopamine ; Electric Stimulation - instrumentation ; Hippocampus - metabolism ; Hypotheses ; Male ; Medical sciences ; Mental depression ; Mental disorders ; Neuropeptide Y - biosynthesis ; Neuropeptide Y - genetics ; Neuropeptides ; Neuropharmacology ; Neuroprotective agent ; Neurosciences ; Olfactory Pathways - metabolism ; Parietal Lobe - metabolism ; Pharmacology. Drug treatments ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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B</creatorcontrib><creatorcontrib>TOSCHI, N</creatorcontrib><creatorcontrib>KRESSE, A. E</creatorcontrib><creatorcontrib>POST, A</creatorcontrib><creatorcontrib>KECK, M. E</creatorcontrib><title>Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacology</addtitle><description>Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a therapeutic tool in various neurological and psychiatric disorders, and we recently found that it has a neuroprotective effect both in vitro and in vivo. However, the neurochemical mechanisms underlying the therapeutic effects are still unknown. We investigated the effects of long-term rTMS on the expression of brain-derived neurotrophic factor (BDNF), cholecystokinin (CCK), and neuropeptide tyrosine (NPY) mRNA in rat brain. In situ hybridization revealed a significant increase in BDNF mRNA in the hippocampal areas CA3 and CA3c, the granule cell layer, as well as in the parietal and the piriform cortex after rTMS. BDNF-like immunoreactivity was markedly increased in the same areas. A significant increase in CCK mRNA was observed in all brain regions examined. NPY mRNA expression, in contrast, was not altered. The present results suggest that BDNF may contribute to the neuroprotective effects of rTMS. Furthermore, the rTMS-induced changes in BDNF and CCK expression are similar to those reported after antidepressant drug treatment and electroconvulsive seizures, suggesting that a common molecular mechanism may underlie different antidepressant treatment strategies.</description><subject>Animals</subject><subject>Antidepressants</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - biosynthesis</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebrospinal fluid</subject><subject>Cholecystokinin - biosynthesis</subject><subject>Cholecystokinin - genetics</subject><subject>Convulsions & seizures</subject><subject>Dentate Gyrus - metabolism</subject><subject>Diseases of the nervous system</subject><subject>Dopamine</subject><subject>Electric Stimulation - instrumentation</subject><subject>Hippocampus - metabolism</subject><subject>Hypotheses</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Neuropeptide Y - biosynthesis</subject><subject>Neuropeptide Y - genetics</subject><subject>Neuropeptides</subject><subject>Neuropharmacology</subject><subject>Neuroprotective agent</subject><subject>Neurosciences</subject><subject>Olfactory Pathways - metabolism</subject><subject>Parietal Lobe - metabolism</subject><subject>Pharmacology. 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B</au><au>TOSCHI, N</au><au>KRESSE, A. E</au><au>POST, A</au><au>KECK, M. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain</atitle><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle><addtitle>Neuropsychopharmacology</addtitle><date>2000-08-01</date><risdate>2000</risdate><volume>23</volume><issue>2</issue><spage>205</spage><epage>215</epage><pages>205-215</pages><issn>0893-133X</issn><eissn>1740-634X</eissn><coden>NEROEW</coden><abstract>Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a therapeutic tool in various neurological and psychiatric disorders, and we recently found that it has a neuroprotective effect both in vitro and in vivo. However, the neurochemical mechanisms underlying the therapeutic effects are still unknown. We investigated the effects of long-term rTMS on the expression of brain-derived neurotrophic factor (BDNF), cholecystokinin (CCK), and neuropeptide tyrosine (NPY) mRNA in rat brain. In situ hybridization revealed a significant increase in BDNF mRNA in the hippocampal areas CA3 and CA3c, the granule cell layer, as well as in the parietal and the piriform cortex after rTMS. BDNF-like immunoreactivity was markedly increased in the same areas. A significant increase in CCK mRNA was observed in all brain regions examined. NPY mRNA expression, in contrast, was not altered. The present results suggest that BDNF may contribute to the neuroprotective effects of rTMS. Furthermore, the rTMS-induced changes in BDNF and CCK expression are similar to those reported after antidepressant drug treatment and electroconvulsive seizures, suggesting that a common molecular mechanism may underlie different antidepressant treatment strategies.</abstract><cop>New York, NY</cop><pub>Nature Publishing</pub><pmid>10882847</pmid><doi>10.1016/S0893-133X(00)00099-3</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antidepressants Biological and medical sciences Brain Brain - metabolism Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - biosynthesis Brain-Derived Neurotrophic Factor - genetics Cerebral Cortex - metabolism Cerebrospinal fluid Cholecystokinin - biosynthesis Cholecystokinin - genetics Convulsions & seizures Dentate Gyrus - metabolism Diseases of the nervous system Dopamine Electric Stimulation - instrumentation Hippocampus - metabolism Hypotheses Male Medical sciences Mental depression Mental disorders Neuropeptide Y - biosynthesis Neuropeptide Y - genetics Neuropeptides Neuropharmacology Neuroprotective agent Neurosciences Olfactory Pathways - metabolism Parietal Lobe - metabolism Pharmacology. Drug treatments Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Rats, Wistar RNA, Messenger - biosynthesis Time Transcranial magnetic stimulation Transcranial Magnetic Stimulation - therapeutic use |
| title | Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain |
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