Cutaneous Papillomavirus E6 Proteins Must Interact with p300 and Block p53-Mediated Apoptosis for Cellular Immortalization and Tumorigenesis

The binding of the papillomavirus E6 protein to E6AP and the induction of p53 degradation are common features of high-risk genital human papillomaviruses (HPV); cutaneous HPVs, on the other hand, lack these capacities. Nevertheless, several cutaneous HPV types of the beta-genus, such as HPV38 are as...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-09, Vol.70 (17), p.6913-6924
Hauptverfasser:	MUENCH, Peter, PROBST, Sonja, SCHUETZ, Johanna, LEIPRECHT, Natalie, BUSCH, Martin, WESSELBORG, Sebastian, STUBENRAUCH, Frank, ITTNER, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Antineoplastic agents Apoptosis - physiology Biological and medical sciences Cell Line, Transformed Cottontail rabbit papillomavirus E1A-Associated p300 Protein - metabolism Human papillomavirus Humans Infectious diseases Keratinocytes - metabolism Keratinocytes - virology Medical sciences Oncogene Proteins, Viral - metabolism Papillomavirus Pharmacology. Drug treatments Rabbits Skin Neoplasms - metabolism Skin Neoplasms - virology Transcription, Genetic Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Viral diseases
Online-Zugang:	Volltext
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