Elucidation of the rapid in vivo metabolism of arecoline
1. 1. The metabolism of arecoline (ARE) was examined in homogenates of mouse blood, brain, kidney, and liver tissue. 2. 2. Liver and kidney tissues exhibited the greatest rates of ARE metabolism. 3. 3. The specific carboxylesterase inhibitor TOCP (tri- o-tolyl-phosphate) as well as ISO-OMPA (tetrais...
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| Veröffentlicht in: | General pharmacology 1993-05, Vol.24 (3), p.641-647 |
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| container_title | General pharmacology |
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| creator | Patterson, T.A. Kosh, J.W. |
| description | 1.
1. The metabolism of arecoline (ARE) was examined in homogenates of mouse blood, brain, kidney, and liver tissue.
2.
2. Liver and kidney tissues exhibited the greatest rates of ARE metabolism.
3.
3. The specific carboxylesterase inhibitor TOCP (tri-
o-tolyl-phosphate) as well as ISO-OMPA (tetraisopropyl-pyrophosphoramide) completely blocked ARE metabolism in liver homogenate.
4.
4. ISO-OMPA significantly inhibited ARE metabolism by purified porcine liver carboxylesterase.
5.
5. The data suggest that carboxylesterase (EC 3.1.1.1) is primarily responsible for the metabolism of ARE in the mouse. |
| doi_str_mv | 10.1016/0306-3623(93)90224-L |
| format | Article |
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1. The metabolism of arecoline (ARE) was examined in homogenates of mouse blood, brain, kidney, and liver tissue.
2.
2. Liver and kidney tissues exhibited the greatest rates of ARE metabolism.
3.
3. The specific carboxylesterase inhibitor TOCP (tri-
o-tolyl-phosphate) as well as ISO-OMPA (tetraisopropyl-pyrophosphoramide) completely blocked ARE metabolism in liver homogenate.
4.
4. ISO-OMPA significantly inhibited ARE metabolism by purified porcine liver carboxylesterase.
5.
5. The data suggest that carboxylesterase (EC 3.1.1.1) is primarily responsible for the metabolism of ARE in the mouse.</description><identifier>ISSN: 0306-3623</identifier><identifier>EISSN: 1879-0011</identifier><identifier>DOI: 10.1016/0306-3623(93)90224-L</identifier><identifier>PMID: 8365645</identifier><identifier>CODEN: GEPHDP</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Arecoline - metabolism ; Biological and medical sciences ; Carboxylic Ester Hydrolases - antagonists & inhibitors ; Carboxylic Ester Hydrolases - metabolism ; Cholinergic system ; Hydrolysis ; In Vitro Techniques ; Kinetics ; Liver - drug effects ; Liver - enzymology ; Liver - metabolism ; Male ; Medical sciences ; Mice ; Mice, Inbred ICR ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology. Drug treatments ; Swine ; Tetraisopropylpyrophosphamide - pharmacology ; Tritolyl Phosphates - pharmacology</subject><ispartof>General pharmacology, 1993-05, Vol.24 (3), p.641-647</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-6e79bd7bc1e8bd1a7b731707e9e3f0be284edbd5f81c5f19261626cbafbfe3fa3</citedby><cites>FETCH-LOGICAL-c386t-6e79bd7bc1e8bd1a7b731707e9e3f0be284edbd5f81c5f19261626cbafbfe3fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4792191$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8365645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patterson, T.A.</creatorcontrib><creatorcontrib>Kosh, J.W.</creatorcontrib><title>Elucidation of the rapid in vivo metabolism of arecoline</title><title>General pharmacology</title><addtitle>Gen Pharmacol</addtitle><description>1.
1. The metabolism of arecoline (ARE) was examined in homogenates of mouse blood, brain, kidney, and liver tissue.
2.
2. Liver and kidney tissues exhibited the greatest rates of ARE metabolism.
3.
3. The specific carboxylesterase inhibitor TOCP (tri-
o-tolyl-phosphate) as well as ISO-OMPA (tetraisopropyl-pyrophosphoramide) completely blocked ARE metabolism in liver homogenate.
4.
4. ISO-OMPA significantly inhibited ARE metabolism by purified porcine liver carboxylesterase.
5.
5. The data suggest that carboxylesterase (EC 3.1.1.1) is primarily responsible for the metabolism of ARE in the mouse.</description><subject>Animals</subject><subject>Arecoline - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carboxylic Ester Hydrolases - antagonists & inhibitors</subject><subject>Carboxylic Ester Hydrolases - metabolism</subject><subject>Cholinergic system</subject><subject>Hydrolysis</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Swine</subject><subject>Tetraisopropylpyrophosphamide - pharmacology</subject><subject>Tritolyl Phosphates - pharmacology</subject><issn>0306-3623</issn><issn>1879-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEQx4MotVa_gcIeRPSwmsdusrkIIr6g4EXPIY8JRvZRk23Bb2-Wlh6FgWH4_2YYfgidE3xLMOF3mGFeMk7ZtWQ3ElNalcsDNCeNkCXGhByi-R45RicpfWOMaU3pDM0axmte1XPUPLVrG5wew9AXgy_GLyiiXgVXhL7YhM1QdDBqM7QhdVOuI9g89HCKjrxuE5zt-gJ9Pj99PL6Wy_eXt8eHZWlZw8eSg5DGCWMJNMYRLYxgRGABEpjHBmhTgTOu9g2xtSeScsIpt0Z74zOh2QJdbe-u4vCzhjSqLiQLbat7GNZJiVoywhnNYLUFbRxSiuDVKoZOx19FsJqEqcmGmmwomWsSppZ57WJ3f206cPulnaGcX-5ynaxufdS9DWmPVUJSIknG7rcYZBebAFElG6C34EI2Nio3hP__-AO7V4bs</recordid><startdate>19930501</startdate><enddate>19930501</enddate><creator>Patterson, T.A.</creator><creator>Kosh, J.W.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930501</creationdate><title>Elucidation of the rapid in vivo metabolism of arecoline</title><author>Patterson, T.A. ; Kosh, J.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-6e79bd7bc1e8bd1a7b731707e9e3f0be284edbd5f81c5f19261626cbafbfe3fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Arecoline - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carboxylic Ester Hydrolases - antagonists & inhibitors</topic><topic>Carboxylic Ester Hydrolases - metabolism</topic><topic>Cholinergic system</topic><topic>Hydrolysis</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>Swine</topic><topic>Tetraisopropylpyrophosphamide - pharmacology</topic><topic>Tritolyl Phosphates - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>Patterson, T.A.</creatorcontrib><creatorcontrib>Kosh, J.W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patterson, T.A.</au><au>Kosh, J.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elucidation of the rapid in vivo metabolism of arecoline</atitle><jtitle>General pharmacology</jtitle><addtitle>Gen Pharmacol</addtitle><date>1993-05-01</date><risdate>1993</risdate><volume>24</volume><issue>3</issue><spage>641</spage><epage>647</epage><pages>641-647</pages><issn>0306-3623</issn><eissn>1879-0011</eissn><coden>GEPHDP</coden><abstract>1.
1. The metabolism of arecoline (ARE) was examined in homogenates of mouse blood, brain, kidney, and liver tissue.
2.
2. Liver and kidney tissues exhibited the greatest rates of ARE metabolism.
3.
3. The specific carboxylesterase inhibitor TOCP (tri-
o-tolyl-phosphate) as well as ISO-OMPA (tetraisopropyl-pyrophosphoramide) completely blocked ARE metabolism in liver homogenate.
4.
4. ISO-OMPA significantly inhibited ARE metabolism by purified porcine liver carboxylesterase.
5.
5. The data suggest that carboxylesterase (EC 3.1.1.1) is primarily responsible for the metabolism of ARE in the mouse.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8365645</pmid><doi>10.1016/0306-3623(93)90224-L</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | General pharmacology, 1993-05, Vol.24 (3), p.641-647 |
| issn | 0306-3623 1879-0011 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Arecoline - metabolism Biological and medical sciences Carboxylic Ester Hydrolases - antagonists & inhibitors Carboxylic Ester Hydrolases - metabolism Cholinergic system Hydrolysis In Vitro Techniques Kinetics Liver - drug effects Liver - enzymology Liver - metabolism Male Medical sciences Mice Mice, Inbred ICR Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Swine Tetraisopropylpyrophosphamide - pharmacology Tritolyl Phosphates - pharmacology |
| title | Elucidation of the rapid in vivo metabolism of arecoline |
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