Reduced 6,6,8-trimethylpterins. Preparation, properties and enzymic reactivities with dihydropteridine reductase, phenylalanine hydroxylase and tyrosine hydroxylase

The substrates of dihydropteridine reductase (EC 1.6.99.7), quinonoid 7,8-dihydro(6 H)pterins, are unstable and decompose in various ways. In attempting to prepare a more stable substrate, 6,6,8-trimethyl-5,6,7,8-tetrahydro(3 H)pterin was synthesised and the quinonoid 6,6,8-trimethyl-7,8-dihydro(6 H...

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Veröffentlicht in:	European journal of biochemistry 1985-01, Vol.146 (2), p.467-474
Hauptverfasser:	Randles, D, Armarego, W L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemical Phenomena Chemistry Coenzymes Dihydropteridine Reductase Drug Stability NADH, NADPH Oxidoreductases Oxidation-Reduction Phenylalanine Hydroxylase Pterins Rats Structure-Activity Relationship Tyrosine 3-Monooxygenase
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