The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression

Beside the well-known deficiency in serotonergic neurotransmission as pathophysiological correlate of major depression (MD), recent evidence points to a pivotal role of increased glutamate receptor activation as well. However, cause and interaction of these neurotransmitter alterations are not under...

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Veröffentlicht in:	Molecular psychiatry 2007-11, Vol.12 (11), p.988-1000
Hauptverfasser:	Müller, N, Schwarz, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Agonists Animals Antidepressants Astrocytes Behavioral Sciences Binding sites Biological and medical sciences Biological Psychology Causes of Central nervous system Cyclooxygenase-2 Cytokines Depression Depression - immunology Depression - metabolism Depression - therapy Development and progression Drug dosages Enzymes feature-review Glutamate Glutamatergic transmission Glutamic Acid - metabolism Glutamic acid receptors Glutamic acid receptors (ionotropic) Health aspects Humans Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - physiology Hypothalamus Hypotheses Immune response Immune system Immune System - physiology Immunosuppressive agents Interleukin 2 Ketamine Major depressive disorder Medical sciences Medicine Medicine & Public Health Mental depression Metabolism Microglia Microglial cells Monooxygenase Mood disorders N-Methyl-D-aspartic acid receptors Neurosciences Neurotoxicity Neurotransmission Pharmacotherapy Pituitary Pituitary-Adrenal System - physiology Properties Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychotherapy Quinolinic acid Receptor mechanisms Serotonin Serotonin - metabolism Tryptophan Tryptophan 2,3-dioxygenase γ-Interferon
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