The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs
Interleukin-12 (IL-12) plays a key role in promoting T helper 1 (Th1) responses and subsequent cell-mediated immunity. Given the role of cytokines in the pathogenesis of psychiatric disorders, the dysregulation of IL-12 in these illnesses would be expected. We measured the plasma levels of IL-12 in...
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| Veröffentlicht in: | Molecular psychiatry 2002-01, Vol.7 (10), p.1107-1114 |
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| creator | KIM, Y-K SUH, I-B KIM, H HAN, C-S LIM, C-S CHOI, S-H LICINIO, J |
| description | Interleukin-12 (IL-12) plays a key role in promoting T helper 1 (Th1) responses and subsequent cell-mediated immunity. Given the role of cytokines in the pathogenesis of psychiatric disorders, the dysregulation of IL-12 in these illnesses would be expected. We measured the plasma levels of IL-12 in 102 psychiatric patients (43 schizophrenia, 34 major depression and 25 bipolar disorder) and 85 normal controls. In addition, IL-12 levels of the patients were measured after an 8-week treatment to assess whether the levels were affected by medication. The IL-12 levels of the patient group with major depression were significantly higher than that of the control group, whereas no differences were found among the other groups. IL-12 values of the three patient groups decreased significantly after 8 weeks of treatment. These findings support the hypothesis that activation of the inflammatory response system and in particular of Th-1-like cells, is involved in the pathophysiology of major depression and that repeated administration of antidepressive and antipsychotic drugs may suppress IL-12 plasma concentrations in psychiatric patients. |
| doi_str_mv | 10.1038/sj.mp.4001084 |
| format | Article |
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Given the role of cytokines in the pathogenesis of psychiatric disorders, the dysregulation of IL-12 in these illnesses would be expected. We measured the plasma levels of IL-12 in 102 psychiatric patients (43 schizophrenia, 34 major depression and 25 bipolar disorder) and 85 normal controls. In addition, IL-12 levels of the patients were measured after an 8-week treatment to assess whether the levels were affected by medication. The IL-12 levels of the patient group with major depression were significantly higher than that of the control group, whereas no differences were found among the other groups. IL-12 values of the three patient groups decreased significantly after 8 weeks of treatment. These findings support the hypothesis that activation of the inflammatory response system and in particular of Th-1-like cells, is involved in the pathophysiology of major depression and that repeated administration of antidepressive and antipsychotic drugs may suppress IL-12 plasma concentrations in psychiatric patients.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/sj.mp.4001084</identifier><identifier>PMID: 12476326</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Affective disorders ; Aged ; Antidepressants ; Antipsychotics ; Biological and medical sciences ; Bipolar disorder ; Bipolar Disorder - blood ; Bipolar Disorder - immunology ; Cell-mediated immunity ; Cytokines ; Depressive Disorder - blood ; Depressive Disorder - immunology ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; Inflammation ; Interleukin 12 ; Interleukin-12 - blood ; Lymphocytes T ; Male ; Medical sciences ; Mental depression ; Mental disorders ; Middle Aged ; Miscellaneous ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Mood disorders ; Patients ; Pharmacology. 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Given the role of cytokines in the pathogenesis of psychiatric disorders, the dysregulation of IL-12 in these illnesses would be expected. We measured the plasma levels of IL-12 in 102 psychiatric patients (43 schizophrenia, 34 major depression and 25 bipolar disorder) and 85 normal controls. In addition, IL-12 levels of the patients were measured after an 8-week treatment to assess whether the levels were affected by medication. The IL-12 levels of the patient group with major depression were significantly higher than that of the control group, whereas no differences were found among the other groups. IL-12 values of the three patient groups decreased significantly after 8 weeks of treatment. These findings support the hypothesis that activation of the inflammatory response system and in particular of Th-1-like cells, is involved in the pathophysiology of major depression and that repeated administration of antidepressive and antipsychotic drugs may suppress IL-12 plasma concentrations in psychiatric patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Affective disorders</subject><subject>Aged</subject><subject>Antidepressants</subject><subject>Antipsychotics</subject><subject>Biological and medical sciences</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - blood</subject><subject>Bipolar Disorder - immunology</subject><subject>Cell-mediated immunity</subject><subject>Cytokines</subject><subject>Depressive Disorder - blood</subject><subject>Depressive Disorder - immunology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin 12</subject><subject>Interleukin-12 - blood</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Mood disorders</subject><subject>Patients</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasma levels</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychotropic drugs</subject><subject>Psychotropic Drugs - pharmacology</subject><subject>Reference Values</subject><subject>Schizophrenia</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenia - immunology</subject><subject>Th1 Cells - immunology</subject><issn>1359-4184</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90ktv1DAQAOAIgWgpHLkiiwq4NItfsR1uVVUeUiUu5WzNOuOulyQOdoIov75eutIKBMgHv74ZPzRV9ZzRFaPCvM3b1TCtJKWMGvmgOmZSq7pptHlYxqJpa8mMPKqe5Lwtpmw2j6sjxstAcHVc_bjeIJl6yAOQHr9jn0n0JIwzph6Xr2GsGS9Tkt0m_IzTJuEY4IwMsI2JdDglzDnE8YzA2JF1mGIPqewW9I6g9-jmXwmnfOs2cU5xCo50abnJT6tHHvqMz_b9SfXl_eX1xcf66vOHTxfnV7VrJJtr7TvjOQPeGSE5BeUUGO1BGRCeOd0CIoKXXau4ByMUdQ7WLWO0xEhg4qR6c593SvHbgnm2Q8gO-x5GjEu2umkFa4yiRb7-v-S60Q1rCzz9A27jksbyCsuVbLTiSu0OfvlPxSkrTIhDqhvo0YbRlz8CtzvXnnNKtSltp1Z_UaV1OAQXR_ShrP8WUN8HuBRzTujtlMIA6dYyandlY_PWDpPdl03xL_Z3XdYDdge9r5MCXu0BZAe9TzC6kA9OivKD2og78V7JZg</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>KIM, Y-K</creator><creator>SUH, I-B</creator><creator>KIM, H</creator><creator>HAN, C-S</creator><creator>LIM, C-S</creator><creator>CHOI, S-H</creator><creator>LICINIO, J</creator><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20020101</creationdate><title>The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs</title><author>KIM, Y-K ; SUH, I-B ; KIM, H ; HAN, C-S ; LIM, C-S ; CHOI, S-H ; LICINIO, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-7fd8f21a2d83420a6c6a87fa68a3f1c79aeeeaf4d962fa8360ccab91101a24a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Affective disorders</topic><topic>Aged</topic><topic>Antidepressants</topic><topic>Antipsychotics</topic><topic>Biological and medical sciences</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - blood</topic><topic>Bipolar Disorder - immunology</topic><topic>Cell-mediated immunity</topic><topic>Cytokines</topic><topic>Depressive Disorder - blood</topic><topic>Depressive Disorder - immunology</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin 12</topic><topic>Interleukin-12 - blood</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Mood disorders</topic><topic>Patients</topic><topic>Pharmacology. 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Given the role of cytokines in the pathogenesis of psychiatric disorders, the dysregulation of IL-12 in these illnesses would be expected. We measured the plasma levels of IL-12 in 102 psychiatric patients (43 schizophrenia, 34 major depression and 25 bipolar disorder) and 85 normal controls. In addition, IL-12 levels of the patients were measured after an 8-week treatment to assess whether the levels were affected by medication. The IL-12 levels of the patient group with major depression were significantly higher than that of the control group, whereas no differences were found among the other groups. IL-12 values of the three patient groups decreased significantly after 8 weeks of treatment. These findings support the hypothesis that activation of the inflammatory response system and in particular of Th-1-like cells, is involved in the pathophysiology of major depression and that repeated administration of antidepressive and antipsychotic drugs may suppress IL-12 plasma concentrations in psychiatric patients.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>12476326</pmid><doi>10.1038/sj.mp.4001084</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Adult and adolescent clinical studies Affective disorders Aged Antidepressants Antipsychotics Biological and medical sciences Bipolar disorder Bipolar Disorder - blood Bipolar Disorder - immunology Cell-mediated immunity Cytokines Depressive Disorder - blood Depressive Disorder - immunology Drug toxicity and drugs side effects treatment Female Humans Inflammation Interleukin 12 Interleukin-12 - blood Lymphocytes T Male Medical sciences Mental depression Mental disorders Middle Aged Miscellaneous Miscellaneous (drug allergy, mutagens, teratogens...) Mood disorders Patients Pharmacology. Drug treatments Plasma levels Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychotropic drugs Psychotropic Drugs - pharmacology Reference Values Schizophrenia Schizophrenia - blood Schizophrenia - immunology Th1 Cells - immunology |
| title | The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs |
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