Serotonin transporter promoter variants in autism: Functional effects and relationship to platelet hyperserotonemia

The well-replicated platelet hyperserotonemia of autism has stimulated interest in serotonin (5-HT) in autism. We have examined the effects of the serotonin transporter gene (5-HTT, locus SLC6A4) promoter polymorphism (5-HTTLPR) on platelet 5-HT physiology in autism. Platelet 5-HT uptake rates and a...

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Veröffentlicht in:	Molecular psychiatry 2002-01, Vol.7 (8), p.831-836
Hauptverfasser:	ANDERSON, G. M, GUTKNECHT, L, COHEN, D. J, BRAILLY-TABARD, S, COHEN, J. H. M, FERRARI, P, ROUBERTOUX, P. L, TORDIMAN, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Alleles Autism Autistic Disorder - blood Autistic Disorder - genetics Biological and medical sciences Blood Platelets - drug effects Blood Platelets - metabolism Carrier Proteins - genetics Child Child clinical studies Citalopram - metabolism Citalopram - pharmacology Developmental disorders Female Gene frequency Gene polymorphism Genetic Variation Genotype Genotype & phenotype High-performance liquid chromatography Humans Infantile autism Linear Models Male Medical sciences Membrane Glycoproteins - genetics Membrane Transport Proteins Nerve Tissue Proteins Platelets Promoter Regions, Genetic - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Serotonin Serotonin - blood Serotonin - pharmacokinetics Serotonin Plasma Membrane Transport Proteins Serotonin transporter Serotonin Uptake Inhibitors - metabolism Serotonin Uptake Inhibitors - pharmacology
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