The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine

We show here that clozapine, a beneficial antipsychotic, down-regulates the expression of the glutamate transporter GLT-1 in the rat cerebral cortex, thereby reducing glutamate transport and raising extracellular glutamate levels. Clozapine treatment (25--35 mg kg(-1) day(-1) orally) reduced GLT-1 i...

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Veröffentlicht in:	Molecular psychiatry 2001-07, Vol.6 (4), p.380-386
Hauptverfasser:	MELONE, M, VITELLARO-ZUCCARELLO, L, VALLEJO-ILLARRAMENDI, A, PEREZ-SAMARTIN, A, MATUTE, C, COZZI, A, PELLEGRINI-GIAMPIETRO, D. E, ROTHSTEIN, J. D, CONTI, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System X-AG Animals Antipsychotic Agents - pharmacology Antipsychotics ATP-Binding Cassette Transporters - analysis ATP-Binding Cassette Transporters - genetics Biological and medical sciences Cerebral cortex Cerebral Cortex - drug effects Cerebral Cortex - metabolism Clozapine Clozapine - pharmacology Cortex (frontal) Dosage and administration Drug therapy Female Frontal Lobe - drug effects Frontal Lobe - metabolism Gene Expression Regulation - drug effects Genetic aspects Glutamate Glutamatergic transmission Glutamic Acid - metabolism Glutamic acid transporter Immunoreactivity In Vitro Techniques Medical sciences Microdialysis mRNA Neuropharmacology Oocytes Oocytes - drug effects Oocytes - physiology Pharmacology. Drug treatments Physiological aspects Potassium chloride Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Psychotropic drugs Rats Rats, Sprague-Dawley Recombinant Proteins - metabolism RNA, Messenger - genetics Schizophrenia Synaptic transmission Xenopus laevis
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