Profiling locomotor recovery: comprehensive quantification of impairments after CNS damage in rodents
This resource provides a comprehensive evaluation of rodent locomotor profiles after different types of lesions to the central nervous system. The data set can guide the selection of suitable lesion paradigms, locomotor tasks and readouts in future animal studies. Rodents are frequently used to mode...
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| Veröffentlicht in: | Nature methods 2010-09, Vol.7 (9), p.701-708 |
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| creator | Schwab, Martin E Gonzenbach, Roman Röthlisberger, Martina Zörner, Björn Kasper, Hansjörg Starkey, Michelle L Bolliger, Marc Filli, Linard |
| description | This resource provides a comprehensive evaluation of rodent locomotor profiles after different types of lesions to the central nervous system. The data set can guide the selection of suitable lesion paradigms, locomotor tasks and readouts in future animal studies.
Rodents are frequently used to model damage and diseases of the central nervous system (CNS) that lead to functional deficits. Impaired locomotor function is currently evaluated by using scoring systems or biomechanical measures. These methods often suffer from limitations such as subjectivity, nonlinearity and low sensitivity, or focus on a few very restricted aspects of movement. Thus, full quantitative profiles of motor deficits after CNS damage are lacking. Here we report the detailed characterization of locomotor impairments after applying common forms of CNS damage in rodents. We obtained many objective and quantitative readouts from rats with either spinal cord injuries or strokes and from transgenic mice (
Epha4
−/−
) during skilled walking, overground walking, wading and swimming, resulting in model-specific locomotor profiles. Our testing and analysis method enables comprehensive assessment of locomotor function in rodents and has broad application in various fields of life science research. |
| doi_str_mv | 10.1038/nmeth.1484 |
| format | Article |
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Rodents are frequently used to model damage and diseases of the central nervous system (CNS) that lead to functional deficits. Impaired locomotor function is currently evaluated by using scoring systems or biomechanical measures. These methods often suffer from limitations such as subjectivity, nonlinearity and low sensitivity, or focus on a few very restricted aspects of movement. Thus, full quantitative profiles of motor deficits after CNS damage are lacking. Here we report the detailed characterization of locomotor impairments after applying common forms of CNS damage in rodents. We obtained many objective and quantitative readouts from rats with either spinal cord injuries or strokes and from transgenic mice (
Epha4
−/−
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Rodents are frequently used to model damage and diseases of the central nervous system (CNS) that lead to functional deficits. Impaired locomotor function is currently evaluated by using scoring systems or biomechanical measures. These methods often suffer from limitations such as subjectivity, nonlinearity and low sensitivity, or focus on a few very restricted aspects of movement. Thus, full quantitative profiles of motor deficits after CNS damage are lacking. Here we report the detailed characterization of locomotor impairments after applying common forms of CNS damage in rodents. We obtained many objective and quantitative readouts from rats with either spinal cord injuries or strokes and from transgenic mice (
Epha4
−/−
) during skilled walking, overground walking, wading and swimming, resulting in model-specific locomotor profiles. Our testing and analysis method enables comprehensive assessment of locomotor function in rodents and has broad application in various fields of life science research.</description><subject>631/1647/2204</subject><subject>631/378/1689</subject><subject>692/1807/1693</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Bioinformatics</subject><subject>Biological Microscopy</subject><subject>Biological Techniques</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering/Biotechnology</subject><subject>Brain damage</subject><subject>Central nervous system</subject><subject>Central Nervous System - injuries</subject><subject>Central Nervous System - physiopathology</subject><subject>Central nervous system diseases</subject><subject>Complications and side effects</subject><subject>Female</subject><subject>Gait</subject><subject>Health aspects</subject><subject>Injuries</subject><subject>Life 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Methods</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>7</volume><issue>9</issue><spage>701</spage><epage>708</epage><pages>701-708</pages><issn>1548-7091</issn><eissn>1548-7105</eissn><abstract>This resource provides a comprehensive evaluation of rodent locomotor profiles after different types of lesions to the central nervous system. The data set can guide the selection of suitable lesion paradigms, locomotor tasks and readouts in future animal studies.
Rodents are frequently used to model damage and diseases of the central nervous system (CNS) that lead to functional deficits. Impaired locomotor function is currently evaluated by using scoring systems or biomechanical measures. These methods often suffer from limitations such as subjectivity, nonlinearity and low sensitivity, or focus on a few very restricted aspects of movement. Thus, full quantitative profiles of motor deficits after CNS damage are lacking. Here we report the detailed characterization of locomotor impairments after applying common forms of CNS damage in rodents. We obtained many objective and quantitative readouts from rats with either spinal cord injuries or strokes and from transgenic mice (
Epha4
−/−
) during skilled walking, overground walking, wading and swimming, resulting in model-specific locomotor profiles. Our testing and analysis method enables comprehensive assessment of locomotor function in rodents and has broad application in various fields of life science research.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>20836253</pmid><doi>10.1038/nmeth.1484</doi><tpages>8</tpages></addata></record> |
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| ispartof | Nature methods, 2010-09, Vol.7 (9), p.701-708 |
| issn | 1548-7091 1548-7105 |
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| subjects | 631/1647/2204 631/378/1689 692/1807/1693 Animal behavior Animals Bioinformatics Biological Microscopy Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology Brain damage Central nervous system Central Nervous System - injuries Central Nervous System - physiopathology Central nervous system diseases Complications and side effects Female Gait Health aspects Injuries Life Sciences Locomotion Locomotion - physiology Mice Mice, Inbred C57BL Motor ability Nervous system Proteomics Psychomotor Disorders - diagnosis Psychomotor Disorders - physiopathology Psychomotor Performance Rats Rats, Inbred Lew Research methodology resource Rodents Swimming Walking |
| title | Profiling locomotor recovery: comprehensive quantification of impairments after CNS damage in rodents |
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