Epstein-Barr virus antibodies in serum and cerebrospinal fluid from Multiple sclerosis, Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Amyotrophic Lateral Sclerosis
Abstract Elevated anti-Epstein-Barr virus (EBV) antibody levels are present in serum of Multiple sclerosis (MS) patients but literature lacks of studies comparing anti-EBV antibody levels between MS and other neurological diseases. We evaluate anti-VCA IgG and IgM, anti-EBNA1 IgG, anti-Cytomegalovir...
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| Veröffentlicht in: | Journal of neuroimmunology 2010-08, Vol.225 (1), p.149-152 |
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| creator | Nociti, V Frisullo, G Marti, A Luigetti, M Iorio, R Patanella, A.K Bianco, A Tonali, P.A Grillo, R.L Sabatelli, M Batocchi, A.P |
| description | Abstract Elevated anti-Epstein-Barr virus (EBV) antibody levels are present in serum of Multiple sclerosis (MS) patients but literature lacks of studies comparing anti-EBV antibody levels between MS and other neurological diseases. We evaluate anti-VCA IgG and IgM, anti-EBNA1 IgG, anti-Cytomegalovirus IgG and IgM titres in serum and cerebrospinal fluid (CSF) of 267 MS, 50 Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) and 88 Amyotrophic Lateral Sclerosis (ALS) patients. We found increased titres of anti-EBV-IgG in serum and CSF of MS subjects as compared to CIDP and ALS patients thus providing additional evidence for a possible involvement of EBV in MS. |
| doi_str_mv | 10.1016/j.jneuroim.2010.04.007 |
| format | Article |
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We evaluate anti-VCA IgG and IgM, anti-EBNA1 IgG, anti-Cytomegalovirus IgG and IgM titres in serum and cerebrospinal fluid (CSF) of 267 MS, 50 Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) and 88 Amyotrophic Lateral Sclerosis (ALS) patients. We found increased titres of anti-EBV-IgG in serum and CSF of MS subjects as compared to CIDP and ALS patients thus providing additional evidence for a possible involvement of EBV in MS.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2010.04.007</identifier><identifier>PMID: 20510468</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Allergy and Immunology ; Amyotrophic Lateral Sclerosis ; Amyotrophic Lateral Sclerosis - blood ; Amyotrophic Lateral Sclerosis - cerebrospinal fluid ; Amyotrophic Lateral Sclerosis - virology ; Antibodies - blood ; Antibodies - cerebrospinal fluid ; Chronic Inflammatory Demyelinating Polyradiculoneuropathy ; Cytomegalovirus ; Epstein-Barr virus ; Female ; Herpesvirus 4, Human - immunology ; Humans ; Male ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis - blood ; Multiple Sclerosis - cerebrospinal fluid ; Multiple Sclerosis - virology ; Neurology ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - blood ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - cerebrospinal fluid ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - virology</subject><ispartof>Journal of neuroimmunology, 2010-08, Vol.225 (1), p.149-152</ispartof><rights>Elsevier B.V.</rights><rights>2010 Elsevier B.V.</rights><rights>Copyright 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-90ad1bb2d4095c46b75b0c3636aef027a2c799e2232cf240074ecd1391103a773</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2010.04.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20510468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nociti, V</creatorcontrib><creatorcontrib>Frisullo, G</creatorcontrib><creatorcontrib>Marti, A</creatorcontrib><creatorcontrib>Luigetti, M</creatorcontrib><creatorcontrib>Iorio, R</creatorcontrib><creatorcontrib>Patanella, A.K</creatorcontrib><creatorcontrib>Bianco, A</creatorcontrib><creatorcontrib>Tonali, P.A</creatorcontrib><creatorcontrib>Grillo, R.L</creatorcontrib><creatorcontrib>Sabatelli, M</creatorcontrib><creatorcontrib>Batocchi, A.P</creatorcontrib><title>Epstein-Barr virus antibodies in serum and cerebrospinal fluid from Multiple sclerosis, Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Amyotrophic Lateral Sclerosis</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract Elevated anti-Epstein-Barr virus (EBV) antibody levels are present in serum of Multiple sclerosis (MS) patients but literature lacks of studies comparing anti-EBV antibody levels between MS and other neurological diseases. We evaluate anti-VCA IgG and IgM, anti-EBNA1 IgG, anti-Cytomegalovirus IgG and IgM titres in serum and cerebrospinal fluid (CSF) of 267 MS, 50 Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) and 88 Amyotrophic Lateral Sclerosis (ALS) patients. We found increased titres of anti-EBV-IgG in serum and CSF of MS subjects as compared to CIDP and ALS patients thus providing additional evidence for a possible involvement of EBV in MS.</description><subject>Adult</subject><subject>Aged</subject><subject>Allergy and Immunology</subject><subject>Amyotrophic Lateral Sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - blood</subject><subject>Amyotrophic Lateral Sclerosis - cerebrospinal fluid</subject><subject>Amyotrophic Lateral Sclerosis - virology</subject><subject>Antibodies - blood</subject><subject>Antibodies - cerebrospinal fluid</subject><subject>Chronic Inflammatory Demyelinating Polyradiculoneuropathy</subject><subject>Cytomegalovirus</subject><subject>Epstein-Barr virus</subject><subject>Female</subject><subject>Herpesvirus 4, Human - immunology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - blood</subject><subject>Multiple Sclerosis - cerebrospinal fluid</subject><subject>Multiple Sclerosis - virology</subject><subject>Neurology</subject><subject>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - blood</subject><subject>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - cerebrospinal fluid</subject><subject>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - virology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFu1DAQhiMEokvhFSrfuJBl7Djx5oIoS4FKi0AqnC3HmbAOTpzaTqU8Fy-It9vlwKUnS6Nv_t8z_2TZBYU1BVq97df9iLN3ZlgzSEXgawDxJFvRjWD5hjP6NFslsMxLwTZn2YsQegBaFrx-np0xKCnwarPK_lxNIaIZ8w_Ke3Jn_ByIGqNpXGswEDOSgH4eUq0lGj023oXJjMqSzs6mJZ13A_k622gmiyRoiwkw4Q3Z7r0bjSbXY2fVMKjo_EI-4rCgTe3RjL_Id2cXr1qjZ-vuh5lU3C_3VpfD4mIq7JPCTkX0yfDmJP4ye9YpG_DVw3ue_fx09WP7Jd99-3y9vdzlmpc85jWoljYNaznUpeZVI8oGdFEVlcIOmFBMi7pGxgqmO8bT-jjqlhY1pVAoIYrz7PVRd_LudsYQ5WCCRmvViG4OUpR1QakQ_HGS1wCsEFUiqyOp0yjBYycnbwblF0lBHpKVvTwlKw_JSuAyfS01XjxYzM2A7b-2U5QJeH8EMK3kzqCXQRscNbbGo46ydeZxj3f_SegUltHK_sYFQ-9mn5IPksrAJMibw30dzotCOq1KQPEXv0LR-Q</recordid><startdate>20100825</startdate><enddate>20100825</enddate><creator>Nociti, V</creator><creator>Frisullo, G</creator><creator>Marti, A</creator><creator>Luigetti, M</creator><creator>Iorio, R</creator><creator>Patanella, A.K</creator><creator>Bianco, A</creator><creator>Tonali, P.A</creator><creator>Grillo, R.L</creator><creator>Sabatelli, M</creator><creator>Batocchi, A.P</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20100825</creationdate><title>Epstein-Barr virus antibodies in serum and cerebrospinal fluid from Multiple sclerosis, Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Amyotrophic Lateral Sclerosis</title><author>Nociti, V ; Frisullo, G ; Marti, A ; Luigetti, M ; Iorio, R ; Patanella, A.K ; Bianco, A ; Tonali, P.A ; Grillo, R.L ; Sabatelli, M ; Batocchi, A.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-90ad1bb2d4095c46b75b0c3636aef027a2c799e2232cf240074ecd1391103a773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Allergy and Immunology</topic><topic>Amyotrophic Lateral Sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - blood</topic><topic>Amyotrophic Lateral Sclerosis - cerebrospinal fluid</topic><topic>Amyotrophic Lateral Sclerosis - virology</topic><topic>Antibodies - blood</topic><topic>Antibodies - cerebrospinal fluid</topic><topic>Chronic Inflammatory Demyelinating Polyradiculoneuropathy</topic><topic>Cytomegalovirus</topic><topic>Epstein-Barr virus</topic><topic>Female</topic><topic>Herpesvirus 4, Human - immunology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - blood</topic><topic>Multiple Sclerosis - cerebrospinal fluid</topic><topic>Multiple Sclerosis - virology</topic><topic>Neurology</topic><topic>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - blood</topic><topic>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - cerebrospinal fluid</topic><topic>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nociti, V</creatorcontrib><creatorcontrib>Frisullo, G</creatorcontrib><creatorcontrib>Marti, A</creatorcontrib><creatorcontrib>Luigetti, M</creatorcontrib><creatorcontrib>Iorio, R</creatorcontrib><creatorcontrib>Patanella, A.K</creatorcontrib><creatorcontrib>Bianco, A</creatorcontrib><creatorcontrib>Tonali, P.A</creatorcontrib><creatorcontrib>Grillo, R.L</creatorcontrib><creatorcontrib>Sabatelli, M</creatorcontrib><creatorcontrib>Batocchi, A.P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nociti, V</au><au>Frisullo, G</au><au>Marti, A</au><au>Luigetti, M</au><au>Iorio, R</au><au>Patanella, A.K</au><au>Bianco, A</au><au>Tonali, P.A</au><au>Grillo, R.L</au><au>Sabatelli, M</au><au>Batocchi, A.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epstein-Barr virus antibodies in serum and cerebrospinal fluid from Multiple sclerosis, Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Amyotrophic Lateral Sclerosis</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2010-08-25</date><risdate>2010</risdate><volume>225</volume><issue>1</issue><spage>149</spage><epage>152</epage><pages>149-152</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract Elevated anti-Epstein-Barr virus (EBV) antibody levels are present in serum of Multiple sclerosis (MS) patients but literature lacks of studies comparing anti-EBV antibody levels between MS and other neurological diseases. 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| ispartof | Journal of neuroimmunology, 2010-08, Vol.225 (1), p.149-152 |
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| language | eng |
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| subjects | Adult Aged Allergy and Immunology Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis - blood Amyotrophic Lateral Sclerosis - cerebrospinal fluid Amyotrophic Lateral Sclerosis - virology Antibodies - blood Antibodies - cerebrospinal fluid Chronic Inflammatory Demyelinating Polyradiculoneuropathy Cytomegalovirus Epstein-Barr virus Female Herpesvirus 4, Human - immunology Humans Male Middle Aged Multiple sclerosis Multiple Sclerosis - blood Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - virology Neurology Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - blood Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - cerebrospinal fluid Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - virology |
| title | Epstein-Barr virus antibodies in serum and cerebrospinal fluid from Multiple sclerosis, Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Amyotrophic Lateral Sclerosis |
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