Role of hormonal and environmental factors on early incidence of breast cancer in Iran
Although the probability of having breast cancer increases with the age in general, this malignancy affects Iranian women at least one decade younger than their counterparts in other countries. However the underlying risk factors for the discrepancy have not been identified. The aryl hydrocarbon rec...
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| Veröffentlicht in: | The Science of the total environment 2010-09, Vol.408 (19), p.4056-4061 |
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| creator | Bidgoli, Sepideh Arbabi Ahmadi, Raziyeh Zavarhei, Mansour Djamali |
| description | Although the probability of having breast cancer increases with the age in general, this malignancy affects Iranian women at least one decade younger than their counterparts in other countries. However the underlying risk factors for the discrepancy have not been identified. The aryl hydrocarbon receptor (AhR) mediates the effects of many environmental endocrine disruptors and contributes to the loss of normal ovarian function in polluted environments. This study was aimed to compare the interactions between AhR and other fundamental genes (p53, K-Ras, ER, PgR) in a clinical setting. To conduct the immunohistochemical studies using appropriate monoclonal antibodies, 25 premenopausal invasive ductal carcinoma, 29 postmenopausal invasive ductal carcinoma and 30 breast fibroadenoma were selected retrospectively from 2004 to 2007 in the pathology department of Imam Khomeini hospital complex of Tehran University of Medical Sciences . Higher levels of AhR in epithelial cells of premenopausal patients and breast fibroadenoma emphasized the susceptibility of these cells to environmental-induced tumors. AhR overexpression contributed to ER-/PgR-immunophenotype in young/premenopausal patients but the same pattern was not observed in benign and postmenopausal malignant tumors. It seems that early incidence of breast cancer in Iran is the result of interactions between hormonal and environmental factors. |
| doi_str_mv | 10.1016/j.scitotenv.2010.05.018 |
| format | Article |
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However the underlying risk factors for the discrepancy have not been identified. The aryl hydrocarbon receptor (AhR) mediates the effects of many environmental endocrine disruptors and contributes to the loss of normal ovarian function in polluted environments. This study was aimed to compare the interactions between AhR and other fundamental genes (p53, K-Ras, ER, PgR) in a clinical setting. To conduct the immunohistochemical studies using appropriate monoclonal antibodies, 25 premenopausal invasive ductal carcinoma, 29 postmenopausal invasive ductal carcinoma and 30 breast fibroadenoma were selected retrospectively from 2004 to 2007 in the pathology department of Imam Khomeini hospital complex of Tehran University of Medical Sciences . Higher levels of AhR in epithelial cells of premenopausal patients and breast fibroadenoma emphasized the susceptibility of these cells to environmental-induced tumors. AhR overexpression contributed to ER-/PgR-immunophenotype in young/premenopausal patients but the same pattern was not observed in benign and postmenopausal malignant tumors. It seems that early incidence of breast cancer in Iran is the result of interactions between hormonal and environmental factors.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2010.05.018</identifier><identifier>PMID: 20541790</identifier><identifier>CODEN: STENDL</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Adolescent ; Adult ; AhR ; Biological and medical sciences ; Breast ; Breast cancer ; Breast fibroadenoma ; Breast Neoplasms - epidemiology ; Breast Neoplasms - etiology ; Breast Neoplasms - metabolism ; Cancer ; Environment. Living conditions ; Environmental Exposure - statistics & numerical data ; Environmental Monitoring ; Epidemiological Monitoring ; Female ; Fibroadenoma - epidemiology ; Fibroadenoma - etiology ; Fibroadenoma - metabolism ; Genes ; Gynecology. Andrology. Obstetrics ; Hospitals ; Humans ; Hydrocarbons ; Incidence ; Iran ; Iran - epidemiology ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Oncogene Protein p21(ras) - metabolism ; Pathology ; Patients ; PgR ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Receptors, Aryl Hydrocarbon - metabolism ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; Sex steroid hormones ; Toxicology ; Tumor Suppressor Protein p53 - metabolism ; Tumors ; Young Adult</subject><ispartof>The Science of the total environment, 2010-09, Vol.408 (19), p.4056-4061</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-7cdb75cc5f08d49b2128e42b6c4cd0a36adca1c144bdcce29b090b44c8fce79d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0048969710004912$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23086520$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20541790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bidgoli, Sepideh Arbabi</creatorcontrib><creatorcontrib>Ahmadi, Raziyeh</creatorcontrib><creatorcontrib>Zavarhei, Mansour Djamali</creatorcontrib><title>Role of hormonal and environmental factors on early incidence of breast cancer in Iran</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>Although the probability of having breast cancer increases with the age in general, this malignancy affects Iranian women at least one decade younger than their counterparts in other countries. However the underlying risk factors for the discrepancy have not been identified. The aryl hydrocarbon receptor (AhR) mediates the effects of many environmental endocrine disruptors and contributes to the loss of normal ovarian function in polluted environments. This study was aimed to compare the interactions between AhR and other fundamental genes (p53, K-Ras, ER, PgR) in a clinical setting. To conduct the immunohistochemical studies using appropriate monoclonal antibodies, 25 premenopausal invasive ductal carcinoma, 29 postmenopausal invasive ductal carcinoma and 30 breast fibroadenoma were selected retrospectively from 2004 to 2007 in the pathology department of Imam Khomeini hospital complex of Tehran University of Medical Sciences . Higher levels of AhR in epithelial cells of premenopausal patients and breast fibroadenoma emphasized the susceptibility of these cells to environmental-induced tumors. AhR overexpression contributed to ER-/PgR-immunophenotype in young/premenopausal patients but the same pattern was not observed in benign and postmenopausal malignant tumors. It seems that early incidence of breast cancer in Iran is the result of interactions between hormonal and environmental factors.</description><subject>Adolescent</subject><subject>Adult</subject><subject>AhR</subject><subject>Biological and medical sciences</subject><subject>Breast</subject><subject>Breast cancer</subject><subject>Breast fibroadenoma</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - etiology</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cancer</subject><subject>Environment. Living conditions</subject><subject>Environmental Exposure - statistics & numerical data</subject><subject>Environmental Monitoring</subject><subject>Epidemiological Monitoring</subject><subject>Female</subject><subject>Fibroadenoma - epidemiology</subject><subject>Fibroadenoma - etiology</subject><subject>Fibroadenoma - metabolism</subject><subject>Genes</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hydrocarbons</subject><subject>Incidence</subject><subject>Iran</subject><subject>Iran - epidemiology</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oncogene Protein p21(ras) - metabolism</subject><subject>Pathology</subject><subject>Patients</subject><subject>PgR</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Receptors, Aryl Hydrocarbon - metabolism</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Sex steroid hormones</subject><subject>Toxicology</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvFSEUgInR2NvqX7BsjN3M9cAwAyybxkeTJiZq3RLmwCg3M1BhbpP-exnvte6UDeHwnUe-Q8g5gy0D1r_dbQuGJS0-3m851Ch0W2DqCdkwJXXDgPdPyQZAqEb3Wp6Q01J2UI9U7Dk54dAJJjVsyLfPafI0jfRHynOKdqI2OlrLhpzi7ONSI6PFJeVCU6Te5umBhojB-Yi_E4fsbVko2vrO9YteZxtfkGejnYp_ebzPyO37d1-vPjY3nz5cX13eNCiUXhqJbpAdYjeCckIPnHHlBR96FOjAtr11aBkyIQaH6LkeQMMgBKoRvdSuPSNvDnXvcvq592Uxcyjop8lGn_bFyE63DJToK3nxT5L1krU967SuqDygmFMp2Y_mLofZ5gfDwKz6zc486jerfgOdqfpr5qtjk_0we_eY98d3BV4fAVvQTmNVhaH85VpQfcdX7vzAjTYZ-z1X5vZL7dTWLnWfHa_E5YHwVe998Hkdad2JC9njYlwK_x33F_a0scg</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Bidgoli, Sepideh Arbabi</creator><creator>Ahmadi, Raziyeh</creator><creator>Zavarhei, Mansour Djamali</creator><general>Elsevier B.V</general><general>[Amsterdam; New York]: Elsevier Science</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SU</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>KR7</scope><scope>7ST</scope><scope>7TV</scope><scope>7U1</scope><scope>7U2</scope><scope>SOI</scope></search><sort><creationdate>20100901</creationdate><title>Role of hormonal and environmental factors on early incidence of breast cancer in Iran</title><author>Bidgoli, Sepideh Arbabi ; Ahmadi, Raziyeh ; Zavarhei, Mansour Djamali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-7cdb75cc5f08d49b2128e42b6c4cd0a36adca1c144bdcce29b090b44c8fce79d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>AhR</topic><topic>Biological and medical sciences</topic><topic>Breast</topic><topic>Breast cancer</topic><topic>Breast fibroadenoma</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - etiology</topic><topic>Breast Neoplasms - metabolism</topic><topic>Cancer</topic><topic>Environment. Living conditions</topic><topic>Environmental Exposure - statistics & numerical data</topic><topic>Environmental Monitoring</topic><topic>Epidemiological Monitoring</topic><topic>Female</topic><topic>Fibroadenoma - epidemiology</topic><topic>Fibroadenoma - etiology</topic><topic>Fibroadenoma - metabolism</topic><topic>Genes</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hydrocarbons</topic><topic>Incidence</topic><topic>Iran</topic><topic>Iran - epidemiology</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oncogene Protein p21(ras) - metabolism</topic><topic>Pathology</topic><topic>Patients</topic><topic>PgR</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Receptors, Aryl Hydrocarbon - metabolism</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Sex steroid hormones</topic><topic>Toxicology</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bidgoli, Sepideh Arbabi</creatorcontrib><creatorcontrib>Ahmadi, Raziyeh</creatorcontrib><creatorcontrib>Zavarhei, Mansour Djamali</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environmental Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environment Abstracts</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bidgoli, Sepideh Arbabi</au><au>Ahmadi, Raziyeh</au><au>Zavarhei, Mansour Djamali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of hormonal and environmental factors on early incidence of breast cancer in Iran</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>408</volume><issue>19</issue><spage>4056</spage><epage>4061</epage><pages>4056-4061</pages><issn>0048-9697</issn><eissn>1879-1026</eissn><coden>STENDL</coden><abstract>Although the probability of having breast cancer increases with the age in general, this malignancy affects Iranian women at least one decade younger than their counterparts in other countries. However the underlying risk factors for the discrepancy have not been identified. The aryl hydrocarbon receptor (AhR) mediates the effects of many environmental endocrine disruptors and contributes to the loss of normal ovarian function in polluted environments. This study was aimed to compare the interactions between AhR and other fundamental genes (p53, K-Ras, ER, PgR) in a clinical setting. To conduct the immunohistochemical studies using appropriate monoclonal antibodies, 25 premenopausal invasive ductal carcinoma, 29 postmenopausal invasive ductal carcinoma and 30 breast fibroadenoma were selected retrospectively from 2004 to 2007 in the pathology department of Imam Khomeini hospital complex of Tehran University of Medical Sciences . Higher levels of AhR in epithelial cells of premenopausal patients and breast fibroadenoma emphasized the susceptibility of these cells to environmental-induced tumors. AhR overexpression contributed to ER-/PgR-immunophenotype in young/premenopausal patients but the same pattern was not observed in benign and postmenopausal malignant tumors. It seems that early incidence of breast cancer in Iran is the result of interactions between hormonal and environmental factors.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>20541790</pmid><doi>10.1016/j.scitotenv.2010.05.018</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult AhR Biological and medical sciences Breast Breast cancer Breast fibroadenoma Breast Neoplasms - epidemiology Breast Neoplasms - etiology Breast Neoplasms - metabolism Cancer Environment. Living conditions Environmental Exposure - statistics & numerical data Environmental Monitoring Epidemiological Monitoring Female Fibroadenoma - epidemiology Fibroadenoma - etiology Fibroadenoma - metabolism Genes Gynecology. Andrology. Obstetrics Hospitals Humans Hydrocarbons Incidence Iran Iran - epidemiology Mammary gland diseases Medical sciences Middle Aged Oncogene Protein p21(ras) - metabolism Pathology Patients PgR Public health. Hygiene Public health. Hygiene-occupational medicine Receptors, Aryl Hydrocarbon - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Sex steroid hormones Toxicology Tumor Suppressor Protein p53 - metabolism Tumors Young Adult |
| title | Role of hormonal and environmental factors on early incidence of breast cancer in Iran |
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