p53 family members in cancer diagnosis and treatment

Abstract p53 is a much studied transcription factor which has a key role in the maintenance of genetic stability. It belongs to a larger family of genes including two other highly related proteins, p63 and p73. The p53 pathway has a vital role in the prevention of cancer formation and is ubiquitousl...

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Veröffentlicht in:	Seminars in cancer biology 2010-02, Vol.20 (1), p.57-62
Hauptverfasser:	Machado-Silva, Alice, Perrier, Stéphane, Bourdon, Jean-Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Cancer Cancer therapy Hematology, Oncology and Palliative Medicine Humans Isoform Mutation - genetics Neoplasms - diagnosis Neoplasms - genetics Neoplasms - therapy p53/p63/p73 Prognosis Protein Isoforms Splicing Tumor Suppressor Protein p53 - genetics Tumor Suppressor Proteins - genetics
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