IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells

Abstract It has been recently shown that systemically injected neural precursor cells (NPCs) could cross brain endothelium and favor functional recovery in animal models of multiple sclerosis (MS). Here we show that human NPCs express receptors of the chemokines IL8 and CXCL13 (CXCR1 and CXCR5, resp...

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Veröffentlicht in:	Journal of neuroimmunology 2010-06, Vol.223 (1), p.131-134
Hauptverfasser:	Weiss, Nicolas, Deboux, Cyrille, Chaverot, Nathalie, Miller, Florence, Baron-Van Evercooren, Anne, Couraud, Pierre-Olivier, Cazaubon, Sylvie
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animal models Blood-brain barrier Brain - immunology Brain - metabolism Cells, Cultured Chemokine CXCL13 - biosynthesis Chemokine CXCL13 - physiology Chemotaxis, Leukocyte - immunology CXCL13 Embryonic Stem Cells - immunology Embryonic Stem Cells - metabolism Embryonic Stem Cells - transplantation Endothelial Cells - immunology Endothelial Cells - metabolism Endothelial Cells - transplantation Humans IL8 Interleukin-8 - biosynthesis Interleukin-8 - physiology Migration Multiple sclerosis Neural precursor cells Neurology Neurons - immunology Neurons - metabolism Neurons - transplantation
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