IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells
Abstract It has been recently shown that systemically injected neural precursor cells (NPCs) could cross brain endothelium and favor functional recovery in animal models of multiple sclerosis (MS). Here we show that human NPCs express receptors of the chemokines IL8 and CXCL13 (CXCR1 and CXCR5, resp...
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| Veröffentlicht in: | Journal of neuroimmunology 2010-06, Vol.223 (1), p.131-134 |
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| container_title | Journal of neuroimmunology |
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| creator | Weiss, Nicolas Deboux, Cyrille Chaverot, Nathalie Miller, Florence Baron-Van Evercooren, Anne Couraud, Pierre-Olivier Cazaubon, Sylvie |
| description | Abstract It has been recently shown that systemically injected neural precursor cells (NPCs) could cross brain endothelium and favor functional recovery in animal models of multiple sclerosis (MS). Here we show that human NPCs express receptors of the chemokines IL8 and CXCL13 (CXCR1 and CXCR5, respectively) and migrate across brain endothelial cells in vitro , in response to these chemokines. Considering that these chemokines have been found overexpressed in MS in active, but not inactive areas of demyelination, our data suggest that systemically injected human NPCs may be considered for targeting active areas of demyelination in therapeutic approaches of MS. |
| doi_str_mv | 10.1016/j.jneuroim.2010.03.009 |
| format | Article |
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Here we show that human NPCs express receptors of the chemokines IL8 and CXCL13 (CXCR1 and CXCR5, respectively) and migrate across brain endothelial cells in vitro , in response to these chemokines. Considering that these chemokines have been found overexpressed in MS in active, but not inactive areas of demyelination, our data suggest that systemically injected human NPCs may be considered for targeting active areas of demyelination in therapeutic approaches of MS.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2010.03.009</identifier><identifier>PMID: 20400187</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Allergy and Immunology ; Animal models ; Blood-brain barrier ; Brain - immunology ; Brain - metabolism ; Cells, Cultured ; Chemokine CXCL13 - biosynthesis ; Chemokine CXCL13 - physiology ; Chemotaxis, Leukocyte - immunology ; CXCL13 ; Embryonic Stem Cells - immunology ; Embryonic Stem Cells - metabolism ; Embryonic Stem Cells - transplantation ; Endothelial Cells - immunology ; Endothelial Cells - metabolism ; Endothelial Cells - transplantation ; Humans ; IL8 ; Interleukin-8 - biosynthesis ; Interleukin-8 - physiology ; Migration ; Multiple sclerosis ; Neural precursor cells ; Neurology ; Neurons - immunology ; Neurons - metabolism ; Neurons - transplantation</subject><ispartof>Journal of neuroimmunology, 2010-06, Vol.223 (1), p.131-134</ispartof><rights>Elsevier B.V.</rights><rights>2010 Elsevier B.V.</rights><rights>Copyright 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-ab51df180e7354257ec17fb4381362226641849009cf5075b968b7d20740bfff3</citedby><cites>FETCH-LOGICAL-c454t-ab51df180e7354257ec17fb4381362226641849009cf5075b968b7d20740bfff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2010.03.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20400187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weiss, Nicolas</creatorcontrib><creatorcontrib>Deboux, Cyrille</creatorcontrib><creatorcontrib>Chaverot, Nathalie</creatorcontrib><creatorcontrib>Miller, Florence</creatorcontrib><creatorcontrib>Baron-Van Evercooren, Anne</creatorcontrib><creatorcontrib>Couraud, Pierre-Olivier</creatorcontrib><creatorcontrib>Cazaubon, Sylvie</creatorcontrib><title>IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract It has been recently shown that systemically injected neural precursor cells (NPCs) could cross brain endothelium and favor functional recovery in animal models of multiple sclerosis (MS). Here we show that human NPCs express receptors of the chemokines IL8 and CXCL13 (CXCR1 and CXCR5, respectively) and migrate across brain endothelial cells in vitro , in response to these chemokines. Considering that these chemokines have been found overexpressed in MS in active, but not inactive areas of demyelination, our data suggest that systemically injected human NPCs may be considered for targeting active areas of demyelination in therapeutic approaches of MS.</description><subject>Allergy and Immunology</subject><subject>Animal models</subject><subject>Blood-brain barrier</subject><subject>Brain - immunology</subject><subject>Brain - metabolism</subject><subject>Cells, Cultured</subject><subject>Chemokine CXCL13 - biosynthesis</subject><subject>Chemokine CXCL13 - physiology</subject><subject>Chemotaxis, Leukocyte - immunology</subject><subject>CXCL13</subject><subject>Embryonic Stem Cells - immunology</subject><subject>Embryonic Stem Cells - metabolism</subject><subject>Embryonic Stem Cells - transplantation</subject><subject>Endothelial Cells - immunology</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelial Cells - transplantation</subject><subject>Humans</subject><subject>IL8</subject><subject>Interleukin-8 - biosynthesis</subject><subject>Interleukin-8 - physiology</subject><subject>Migration</subject><subject>Multiple sclerosis</subject><subject>Neural precursor cells</subject><subject>Neurology</subject><subject>Neurons - immunology</subject><subject>Neurons - metabolism</subject><subject>Neurons - transplantation</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEokvhL1S-cdplbMexc0GgFR-VVuIASNwsxxlrnSb2YidF_fc43ZYDl56s8Tzz-U5VXVHYUaDNu2E3BFxS9NOOQfkEvgNon1UbqiTbqprR59WmgGIrJFMX1aucBwAqeN2-rC4Y1MVQclP9uT4oYkJP9r_2B8qJSUhOccYwE3vEKd74gJm4mMh8RJLQpsXP0-qOjhyXyQSy9mFGcirOJeVCWhzHTIxNMWfSJeMDwdDHkmD0Bbx3v65eODNmfPPwXlY_P3_6sf-6PXz7cr3_eNjaWtTz1nSC9o4qQMlFzYRES6Xraq4obxhjTVNTVbdldOsESNG1jepkz0DW0Dnn-GX19pz3lOLvBfOsJ5_XDkzAuGQtRctBttA8TXLOFACoQjZn8n7ChE6fkp9MutMU9KqOHvSjOnpVRwPXpcUSePVQYukm7P-FPcpRgA9nAMtKbj0mna3HYLH3Zbuz7qN_usb7_1LY0QdvzXiDd5iHuKRQFq6pzkyD_r7eyHoitIxGaQv8L7--uF8</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Weiss, Nicolas</creator><creator>Deboux, Cyrille</creator><creator>Chaverot, Nathalie</creator><creator>Miller, Florence</creator><creator>Baron-Van Evercooren, Anne</creator><creator>Couraud, Pierre-Olivier</creator><creator>Cazaubon, Sylvie</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope></search><sort><creationdate>20100601</creationdate><title>IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells</title><author>Weiss, Nicolas ; Deboux, Cyrille ; Chaverot, Nathalie ; Miller, Florence ; Baron-Van Evercooren, Anne ; Couraud, Pierre-Olivier ; Cazaubon, Sylvie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-ab51df180e7354257ec17fb4381362226641849009cf5075b968b7d20740bfff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Allergy and Immunology</topic><topic>Animal models</topic><topic>Blood-brain barrier</topic><topic>Brain - immunology</topic><topic>Brain - metabolism</topic><topic>Cells, Cultured</topic><topic>Chemokine CXCL13 - biosynthesis</topic><topic>Chemokine CXCL13 - physiology</topic><topic>Chemotaxis, Leukocyte - immunology</topic><topic>CXCL13</topic><topic>Embryonic Stem Cells - immunology</topic><topic>Embryonic Stem Cells - metabolism</topic><topic>Embryonic Stem Cells - transplantation</topic><topic>Endothelial Cells - immunology</topic><topic>Endothelial Cells - metabolism</topic><topic>Endothelial Cells - transplantation</topic><topic>Humans</topic><topic>IL8</topic><topic>Interleukin-8 - biosynthesis</topic><topic>Interleukin-8 - physiology</topic><topic>Migration</topic><topic>Multiple sclerosis</topic><topic>Neural precursor cells</topic><topic>Neurology</topic><topic>Neurons - immunology</topic><topic>Neurons - metabolism</topic><topic>Neurons - transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weiss, Nicolas</creatorcontrib><creatorcontrib>Deboux, Cyrille</creatorcontrib><creatorcontrib>Chaverot, Nathalie</creatorcontrib><creatorcontrib>Miller, Florence</creatorcontrib><creatorcontrib>Baron-Van Evercooren, Anne</creatorcontrib><creatorcontrib>Couraud, Pierre-Olivier</creatorcontrib><creatorcontrib>Cazaubon, Sylvie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weiss, Nicolas</au><au>Deboux, Cyrille</au><au>Chaverot, Nathalie</au><au>Miller, Florence</au><au>Baron-Van Evercooren, Anne</au><au>Couraud, Pierre-Olivier</au><au>Cazaubon, Sylvie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>223</volume><issue>1</issue><spage>131</spage><epage>134</epage><pages>131-134</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract It has been recently shown that systemically injected neural precursor cells (NPCs) could cross brain endothelium and favor functional recovery in animal models of multiple sclerosis (MS). Here we show that human NPCs express receptors of the chemokines IL8 and CXCL13 (CXCR1 and CXCR5, respectively) and migrate across brain endothelial cells in vitro , in response to these chemokines. Considering that these chemokines have been found overexpressed in MS in active, but not inactive areas of demyelination, our data suggest that systemically injected human NPCs may be considered for targeting active areas of demyelination in therapeutic approaches of MS.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>20400187</pmid><doi>10.1016/j.jneuroim.2010.03.009</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allergy and Immunology Animal models Blood-brain barrier Brain - immunology Brain - metabolism Cells, Cultured Chemokine CXCL13 - biosynthesis Chemokine CXCL13 - physiology Chemotaxis, Leukocyte - immunology CXCL13 Embryonic Stem Cells - immunology Embryonic Stem Cells - metabolism Embryonic Stem Cells - transplantation Endothelial Cells - immunology Endothelial Cells - metabolism Endothelial Cells - transplantation Humans IL8 Interleukin-8 - biosynthesis Interleukin-8 - physiology Migration Multiple sclerosis Neural precursor cells Neurology Neurons - immunology Neurons - metabolism Neurons - transplantation |
| title | IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells |
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