The glucagon receptor antagonist BI-32169 constitutes a new class of lasso peptides
The glucagon receptor antagonist BI-32169, recently isolated from Streptomyces sp., was described as a bicyclic peptide, although its primary structure comprises conserved elements of class I and class II lasso peptides. Tandem mass spectrometric and nuclear magnetic resonance spectroscopic studies...
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| Veröffentlicht in: | FEBS letters 2010-02, Vol.584 (4), p.785-789 |
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| creator | Knappe, Thomas A. Linne, Uwe Xie, Xiulan Marahiel, Mohamed A. |
| description | The glucagon receptor antagonist BI-32169, recently isolated from Streptomyces sp., was described as a bicyclic peptide, although its primary structure comprises conserved elements of class I and class II lasso peptides. Tandem mass spectrometric and nuclear magnetic resonance spectroscopic studies revealed that BI-32169 is a lasso-structured peptide constituting the new class III of lasso peptides. The determined lasso fold opens new avenues to improve the promising biological activity of BI-32169. |
| doi_str_mv | 10.1016/j.febslet.2009.12.046 |
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Tandem mass spectrometric and nuclear magnetic resonance spectroscopic studies revealed that BI-32169 is a lasso-structured peptide constituting the new class III of lasso peptides. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via Wiley Online Library; Access via ScienceDirect (Elsevier); Wiley Online Library (Open Access Collection); Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - pharmacology Chromatography, High Pressure Liquid Disulfide bond formation Glucagon receptor antagonist Lasso peptide Magnetic Resonance Spectroscopy Mass fragmentation Models, Molecular Molecular Sequence Data NMR structure Peptides, Cyclic - chemistry Peptides, Cyclic - genetics Peptides, Cyclic - pharmacology Protein Conformation Protein Folding Protein scaffold Receptors, Glucagon - antagonists & inhibitors Streptomyces Streptomyces - metabolism Tandem Mass Spectrometry - methods |
| title | The glucagon receptor antagonist BI-32169 constitutes a new class of lasso peptides |
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