A comparison of the efficacy of azithromycin and clarithromycin in oral therapy of experimental airborne legionnaires' disease
The activities of two new macrolides, azithromycin and clarithromycin, were compared in an aerosol-infected guinea-pig model of legionnaires' disease. The results of this study indicate that a low oral dose of azithromycin (3.6 mg/kg) administered once daily gives 100% survival in Legionella pn...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1993-06, Vol.31 (suppl-E), p.171-176 |
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| container_end_page | 176 |
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| container_issue | suppl-E |
| container_start_page | 171 |
| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 31 |
| creator | Fitzgeorge, R. B. Lever, S. Baskerville, A. |
| description | The activities of two new macrolides, azithromycin and clarithromycin, were compared in an aerosol-infected guinea-pig model of legionnaires' disease. The results of this study indicate that a low oral dose of azithromycin (3.6 mg/kg) administered once daily gives 100% survival in Legionella pneumophila-infected animals. An eight-fold higher dose of clarithromycin (28.8mg/kg) given twice-daily was required to achieve the same effect. Similarly, azithromycin was more effective than clarithromycin in preventing pyrexia and in reducing numbers of bacteria and lesions in the lung. |
| doi_str_mv | 10.1093/jac/31.suppl_E.171 |
| format | Article |
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B.</creatorcontrib><creatorcontrib>Lever, S.</creatorcontrib><creatorcontrib>Baskerville, A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fitzgeorge, R. 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| fulltext | fulltext |
| identifier | ISSN: 0305-7453 |
| ispartof | Journal of antimicrobial chemotherapy, 1993-06, Vol.31 (suppl-E), p.171-176 |
| issn | 0305-7453 1460-2091 |
| language | eng |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Administration, Inhalation Administration, Oral Aerosols Animals Azithromycin Clarithromycin - pharmacology Disease Models, Animal Erythromycin - analogs & derivatives Erythromycin - pharmacology Female Guinea Pigs Legionella pneumophila Legionnaires' Disease - drug therapy Legionnaires' Disease - microbiology Legionnaires' Disease - pathology Lung - microbiology Lung - pathology |
| title | A comparison of the efficacy of azithromycin and clarithromycin in oral therapy of experimental airborne legionnaires' disease |
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