Specific binding of [3H-Tyr8]physalaemin to rat submaxillary gland substance P receptor

[3H]Physalaemin [( 3H]PHY) binds to a single class of noninteracting sites on rat submaxillary gland membranes suspended in high ionic strength media with a KD of 2.7 nM, a Bmax of 240 fmol/mg of protein, and low nonspecific binding. The relative potencies of substance P (SP) and its fragments in co...

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Veröffentlicht in:	Molecular pharmacology 1985-01, Vol.27 (1), p.38-45
Hauptverfasser:	BAHOUTH, S. W, LAZARO, D. M, BRUNDISH, D. E, MUSACCHIO, J. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Biological and medical sciences Kinetics Kinins - metabolism Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Osmolar Concentration Pharmacology. Drug treatments Physalaemin - chemical synthesis Physalaemin - metabolism Rats Receptors, Neurokinin-1 Receptors, Neurotransmitter - metabolism Submandibular Gland - metabolism Substance P - metabolism Tritium
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