Identification and typing of human papillomavirus in cervical cancers in taiwan
Background. Although human papillomaviruses (HPV) are associated with cervical cancer, it has yet to be determined if specific HPV types have clinical or prognostic significance. Methods. Identification and typing of HPV were done by polymerase chain reaction (PCR) and restriction fragment length po...
Gespeichert in:
| Veröffentlicht in: | Cancer 1993-09, Vol.72 (6), p.1939-1945 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1945 |
|---|---|
| container_issue | 6 |
| container_start_page | 1939 |
| container_title | Cancer |
| container_volume | 72 |
| creator | Chen, Show‐Li Han, Chih‐Ping Tsao, Yeou‐Ping Lee, Jeng‐Woei Yin, Chang‐Sheng |
| description | Background. Although human papillomaviruses (HPV) are associated with cervical cancer, it has yet to be determined if specific HPV types have clinical or prognostic significance.
Methods. Identification and typing of HPV were done by polymerase chain reaction (PCR) and restriction fragment length polymorphism.
Results. Of the 43 cases of cervical cancer, 31 (72%) were HPV positive. The results of HPV typing in 40 cases of squamous cell carcinoma of the cervix revealed the presence of HPV‐16 in 20 cases (50%), HPV‐18 in 2 cases, HPV‐11 in 1 case, HPV‐33 in 1 case, HPV‐52 in 1 case, HPV‐58 in 1 case, and unidentified HPV types in 5 cases. Neither HPV‐31 nor HPV‐42 were present in our study. One case of squamous cell carcinoma had HPV‐11 integration. Chi‐square analysis revealed significant correlation between HPV genotypes and squamous cell patterns, no significant correlation between HPV genotypes and clinical stages, and cell differentiation of squamous cell carcinoma of cervix.
Conclusions. These findings may contribute to understanding the role of HPV in cancer and the value of typing as a prognostic indicator. |
| doi_str_mv | 10.1002/1097-0142(19930915)72:6<1939::AID-CNCR2820720624>3.0.CO;2-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75928691</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75928691</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4984-198209d423096e10ce02a2ad17592dbcf9cd4bb84772f95a3ec675e78b3cf3d23</originalsourceid><addsrcrecordid>eNqVkF2L1DAYhYMo6-zqTxB6IaIXHZM3adOMIiz1a2BxQBQEL17SNNVIm9am3WX-_abOOKAXglf5OOc9OXkIKRldM0rhOaNKppQJeMqU4lSx7JmETf6SKa42m8vt67T8UH6EAqgEmoN4xdd0Xe5eQAp3yOo0fZesKKVFmgn-5T45D-FHPErI-Bk5KxjlghUrstvW1k-ucUZPrveJ9nUy7QfnvyV9k3yfO-2TQQ-ubftOX7txDonzibHjdZxoE6N93P-6m7S70f4BudfoNtiHx_WCfH775lP5Pr3avduWl1epEaoQKVOxvaoFxO_lllFjKWjQNZOZgroyjTK1qKpCSAmNyjS3JpeZlUXFTcNr4BfkySF3GPufsw0Tdi4Y27ba234OuOQUuWLR-PVgNGMfwmgbHEbX6XGPjOKCGxdguADD37hRAua44EaMuPFP3MiRYrlDwKXGo2ONuepsfco-8o3646OuQ-TVjJGXCyebiI9xuZRsDrYb19r9_zX8Z8G_FH4Lzuiptg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75928691</pqid></control><display><type>article</type><title>Identification and typing of human papillomavirus in cervical cancers in taiwan</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Chen, Show‐Li ; Han, Chih‐Ping ; Tsao, Yeou‐Ping ; Lee, Jeng‐Woei ; Yin, Chang‐Sheng</creator><creatorcontrib>Chen, Show‐Li ; Han, Chih‐Ping ; Tsao, Yeou‐Ping ; Lee, Jeng‐Woei ; Yin, Chang‐Sheng</creatorcontrib><description>Background. Although human papillomaviruses (HPV) are associated with cervical cancer, it has yet to be determined if specific HPV types have clinical or prognostic significance.
Methods. Identification and typing of HPV were done by polymerase chain reaction (PCR) and restriction fragment length polymorphism.
Results. Of the 43 cases of cervical cancer, 31 (72%) were HPV positive. The results of HPV typing in 40 cases of squamous cell carcinoma of the cervix revealed the presence of HPV‐16 in 20 cases (50%), HPV‐18 in 2 cases, HPV‐11 in 1 case, HPV‐33 in 1 case, HPV‐52 in 1 case, HPV‐58 in 1 case, and unidentified HPV types in 5 cases. Neither HPV‐31 nor HPV‐42 were present in our study. One case of squamous cell carcinoma had HPV‐11 integration. Chi‐square analysis revealed significant correlation between HPV genotypes and squamous cell patterns, no significant correlation between HPV genotypes and clinical stages, and cell differentiation of squamous cell carcinoma of cervix.
Conclusions. These findings may contribute to understanding the role of HPV in cancer and the value of typing as a prognostic indicator.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19930915)72:6<1939::AID-CNCR2820720624>3.0.CO;2-2</identifier><identifier>PMID: 8103418</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma - microbiology ; Adult ; Aged ; Base Sequence ; Biological and medical sciences ; Blotting, Southern ; Carcinoma, Squamous Cell - microbiology ; cervical cancer ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; human papillomavirus ; Humans ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Papillomaviridae - classification ; Papillomaviridae - isolation & purification ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; restriction fragment length polymorphism ; Taiwan ; Tumors ; Uterine Cervical Neoplasms - microbiology</subject><ispartof>Cancer, 1993-09, Vol.72 (6), p.1939-1945</ispartof><rights>Copyright © 1993 American Cancer Society</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4984-198209d423096e10ce02a2ad17592dbcf9cd4bb84772f95a3ec675e78b3cf3d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4915371$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8103418$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Show‐Li</creatorcontrib><creatorcontrib>Han, Chih‐Ping</creatorcontrib><creatorcontrib>Tsao, Yeou‐Ping</creatorcontrib><creatorcontrib>Lee, Jeng‐Woei</creatorcontrib><creatorcontrib>Yin, Chang‐Sheng</creatorcontrib><title>Identification and typing of human papillomavirus in cervical cancers in taiwan</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Background. Although human papillomaviruses (HPV) are associated with cervical cancer, it has yet to be determined if specific HPV types have clinical or prognostic significance.
Methods. Identification and typing of HPV were done by polymerase chain reaction (PCR) and restriction fragment length polymorphism.
Results. Of the 43 cases of cervical cancer, 31 (72%) were HPV positive. The results of HPV typing in 40 cases of squamous cell carcinoma of the cervix revealed the presence of HPV‐16 in 20 cases (50%), HPV‐18 in 2 cases, HPV‐11 in 1 case, HPV‐33 in 1 case, HPV‐52 in 1 case, HPV‐58 in 1 case, and unidentified HPV types in 5 cases. Neither HPV‐31 nor HPV‐42 were present in our study. One case of squamous cell carcinoma had HPV‐11 integration. Chi‐square analysis revealed significant correlation between HPV genotypes and squamous cell patterns, no significant correlation between HPV genotypes and clinical stages, and cell differentiation of squamous cell carcinoma of cervix.
Conclusions. These findings may contribute to understanding the role of HPV in cancer and the value of typing as a prognostic indicator.</description><subject>Adenocarcinoma - microbiology</subject><subject>Adult</subject><subject>Aged</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Southern</subject><subject>Carcinoma, Squamous Cell - microbiology</subject><subject>cervical cancer</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>human papillomavirus</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Papillomaviridae - classification</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>restriction fragment length polymorphism</subject><subject>Taiwan</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - microbiology</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF2L1DAYhYMo6-zqTxB6IaIXHZM3adOMIiz1a2BxQBQEL17SNNVIm9am3WX-_abOOKAXglf5OOc9OXkIKRldM0rhOaNKppQJeMqU4lSx7JmETf6SKa42m8vt67T8UH6EAqgEmoN4xdd0Xe5eQAp3yOo0fZesKKVFmgn-5T45D-FHPErI-Bk5KxjlghUrstvW1k-ucUZPrveJ9nUy7QfnvyV9k3yfO-2TQQ-ubftOX7txDonzibHjdZxoE6N93P-6m7S70f4BudfoNtiHx_WCfH775lP5Pr3avduWl1epEaoQKVOxvaoFxO_lllFjKWjQNZOZgroyjTK1qKpCSAmNyjS3JpeZlUXFTcNr4BfkySF3GPufsw0Tdi4Y27ba234OuOQUuWLR-PVgNGMfwmgbHEbX6XGPjOKCGxdguADD37hRAua44EaMuPFP3MiRYrlDwKXGo2ONuepsfco-8o3646OuQ-TVjJGXCyebiI9xuZRsDrYb19r9_zX8Z8G_FH4Lzuiptg</recordid><startdate>19930915</startdate><enddate>19930915</enddate><creator>Chen, Show‐Li</creator><creator>Han, Chih‐Ping</creator><creator>Tsao, Yeou‐Ping</creator><creator>Lee, Jeng‐Woei</creator><creator>Yin, Chang‐Sheng</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930915</creationdate><title>Identification and typing of human papillomavirus in cervical cancers in taiwan</title><author>Chen, Show‐Li ; Han, Chih‐Ping ; Tsao, Yeou‐Ping ; Lee, Jeng‐Woei ; Yin, Chang‐Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4984-198209d423096e10ce02a2ad17592dbcf9cd4bb84772f95a3ec675e78b3cf3d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adenocarcinoma - microbiology</topic><topic>Adult</topic><topic>Aged</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blotting, Southern</topic><topic>Carcinoma, Squamous Cell - microbiology</topic><topic>cervical cancer</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>human papillomavirus</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Papillomaviridae - classification</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>restriction fragment length polymorphism</topic><topic>Taiwan</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Show‐Li</creatorcontrib><creatorcontrib>Han, Chih‐Ping</creatorcontrib><creatorcontrib>Tsao, Yeou‐Ping</creatorcontrib><creatorcontrib>Lee, Jeng‐Woei</creatorcontrib><creatorcontrib>Yin, Chang‐Sheng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Show‐Li</au><au>Han, Chih‐Ping</au><au>Tsao, Yeou‐Ping</au><au>Lee, Jeng‐Woei</au><au>Yin, Chang‐Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification and typing of human papillomavirus in cervical cancers in taiwan</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1993-09-15</date><risdate>1993</risdate><volume>72</volume><issue>6</issue><spage>1939</spage><epage>1945</epage><pages>1939-1945</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Background. Although human papillomaviruses (HPV) are associated with cervical cancer, it has yet to be determined if specific HPV types have clinical or prognostic significance.
Methods. Identification and typing of HPV were done by polymerase chain reaction (PCR) and restriction fragment length polymorphism.
Results. Of the 43 cases of cervical cancer, 31 (72%) were HPV positive. The results of HPV typing in 40 cases of squamous cell carcinoma of the cervix revealed the presence of HPV‐16 in 20 cases (50%), HPV‐18 in 2 cases, HPV‐11 in 1 case, HPV‐33 in 1 case, HPV‐52 in 1 case, HPV‐58 in 1 case, and unidentified HPV types in 5 cases. Neither HPV‐31 nor HPV‐42 were present in our study. One case of squamous cell carcinoma had HPV‐11 integration. Chi‐square analysis revealed significant correlation between HPV genotypes and squamous cell patterns, no significant correlation between HPV genotypes and clinical stages, and cell differentiation of squamous cell carcinoma of cervix.
Conclusions. These findings may contribute to understanding the role of HPV in cancer and the value of typing as a prognostic indicator.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8103418</pmid><doi>10.1002/1097-0142(19930915)72:6<1939::AID-CNCR2820720624>3.0.CO;2-2</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-543X |
| ispartof | Cancer, 1993-09, Vol.72 (6), p.1939-1945 |
| issn | 0008-543X 1097-0142 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75928691 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - microbiology Adult Aged Base Sequence Biological and medical sciences Blotting, Southern Carcinoma, Squamous Cell - microbiology cervical cancer Female Female genital diseases Gynecology. Andrology. Obstetrics human papillomavirus Humans Medical sciences Middle Aged Molecular Sequence Data Papillomaviridae - classification Papillomaviridae - isolation & purification Polymerase Chain Reaction Polymorphism, Restriction Fragment Length restriction fragment length polymorphism Taiwan Tumors Uterine Cervical Neoplasms - microbiology |
| title | Identification and typing of human papillomavirus in cervical cancers in taiwan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T17%3A34%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Identification%20and%20typing%20of%20human%20papillomavirus%20in%20cervical%20cancers%20in%20taiwan&rft.jtitle=Cancer&rft.au=Chen,%20Show%E2%80%90Li&rft.date=1993-09-15&rft.volume=72&rft.issue=6&rft.spage=1939&rft.epage=1945&rft.pages=1939-1945&rft.issn=0008-543X&rft.eissn=1097-0142&rft.coden=CANCAR&rft_id=info:doi/10.1002/1097-0142(19930915)72:6%3C1939::AID-CNCR2820720624%3E3.0.CO;2-2&rft_dat=%3Cproquest_cross%3E75928691%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75928691&rft_id=info:pmid/8103418&rfr_iscdi=true |