Analogs of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 2. The amide bond "B-region"

A series of compounds incorporating replacements for the amide bond "B-region" moiety of capsaicin have been synthesized, including vanillylamides and esters, homovanillic acid amides and esters, ureas, and thioureas. These have been tested in an in vitro assay for agonism (45Ca2+ influx i...

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Veröffentlicht in:	Journal of medicinal chemistry 1993-08, Vol.36 (16), p.2373-2380
Hauptverfasser:	Walpole, Christopher S. J, Wrigglesworth, Roger, Bevan, Stuart, Campbell, Elizabeth A, Dray, Andy, James, Iain F, Masdin, Kay J, Perkins, Martin N, Winter, Janet
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - chemistry Analgesics - pharmacology Animals Calcium - metabolism Calcium Channel Agonists - chemistry Calcium Channel Agonists - pharmacology Capsaicin - analogs & derivatives Capsaicin - chemistry Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Guinea Pigs Ileum Mice Muscle Contraction - drug effects Structure-Activity Relationship
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