The role of high density lipoproteins in the biodistribution of two radioiodinated probes in the rat

Two radioiodinated probes, 125I-cholesteryl oleate ( 125I-CO), a derivative of a natural constituent of lipoproteins, and 1-(2-chlorophenyl)-1-(4[ 125I]iodophenyl)-2,2-dichloroethane ( 125I-DDD), an analog of the adrenolytic drug o,p′-DDD (mitotane), were selected to study the role of lipoproteins i...

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Veröffentlicht in:	Toxicol. Appl. Pharmacol.; (United States) 1985, Vol.77 (1), p.47-57
Hauptverfasser:	Pohland, Raymond C., Counsell, Raymond E.
Format:	Artikel
Sprache:	eng
Schlagworte:	19-Iodocholesterol - analogs & derivatives 19-Iodocholesterol - metabolism 19-Iodocholesterol - pharmacology 550201 - Biochemistry- Tracer Techniques ADRENAL GLANDS Adrenal Glands - drug effects Adrenal Glands - metabolism Animals BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BIOCHEMISTRY Biological and medical sciences BODY CARBOXYLIC ACIDS CHEMISTRY CHOLESTEROL Cholesterol - analogs & derivatives DAYS LIVING RADIOISOTOPES DISTRIBUTION ELECTRON CAPTURE RADIOISOTOPES ELECTROPHORESIS Electrophoresis, Polyacrylamide Gel ENDOCRINE GLANDS Female General pharmacology GLANDS HYDROXY COMPOUNDS Injections, Intraperitoneal INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES Iodine Radioisotopes ISOTOPE APPLICATIONS ISOTOPES LABELLED COMPOUNDS LIPIDS LIPOPROTEINS Lipoproteins, HDL - metabolism Medical sciences Mitotane - analogs & derivatives Mitotane - metabolism Mitotane - pharmacology MONOCARBOXYLIC ACIDS NUCLEI ODD-EVEN NUCLEI OLEIC ACID ORGANIC ACIDS ORGANIC COMPOUNDS ORGANS Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments PROBES PROTEINS RADIOISOTOPES Rats Rats, Inbred Strains RECEPTORS STEROIDS STEROLS TISSUE DISTRIBUTION TRACER TECHNIQUES UPTAKE
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