Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis

Germ-line mutations in the adenomatous polyposis coli (APC) gene result in familial adenomatous polyposis coll (APC), an inherited syndrome that predisposes affected Individuals to early onset of colorectal cancer. Somatic APC mutations also have been detected in sporadic colon tumors. We have used...

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