PYRROLOSTATIN, A NOVEL LIPID PEROXIDATION INHIBITOR FROM Streptomyces chrestomyceticus: TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES
Pyrrolostatin, a new lipid peroxidation inhibitor, was isolated from the culture of Streptomyces chrestomyceticus EC40. The structure was determined to be 4-geranylpyrrole-2-carboxylic acid on the basis of its spectroscopic and physico-chemical properties. Pyrrolostatin inhibited lipid peroxidation...
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| Veröffentlicht in: | Journal of antibiotics 1993/06/25, Vol.46(6), pp.892-899 |
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| container_end_page | 899 |
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| container_issue | 6 |
| container_start_page | 892 |
| container_title | Journal of antibiotics |
| container_volume | 46 |
| creator | KATO, SHINICHIRO SHINDO, KAZUTOSHI KAWAI, HIROYUKI ODAGAWA, ATSUO MATSUOKA, MICHIKO MOCHIZUKI, JUNICHIRO |
| description | Pyrrolostatin, a new lipid peroxidation inhibitor, was isolated from the culture of Streptomyces chrestomyceticus EC40. The structure was determined to be 4-geranylpyrrole-2-carboxylic acid on the basis of its spectroscopic and physico-chemical properties. Pyrrolostatin inhibited lipid peroxidation in rat brain homogenate. |
| doi_str_mv | 10.7164/antibiotics.46.892 |
| format | Article |
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The structure was determined to be 4-geranylpyrrole-2-carboxylic acid on the basis of its spectroscopic and physico-chemical properties. Pyrrolostatin inhibited lipid peroxidation in rat brain homogenate.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.46.892</identifier><identifier>PMID: 8344870</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Animals ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Fermentation ; General and cellular metabolism. Vitamins ; Hypoxia - prevention & control ; Lipid Peroxidation - drug effects ; Male ; Medical sciences ; Mice ; Pharmacology. Drug treatments ; Proline - analogs & derivatives ; Proline - chemistry ; Proline - isolation & purification ; Proline - pharmacology ; Pyrroles - chemistry ; Pyrroles - isolation & purification ; Pyrroles - pharmacology ; Rats ; Rats, Wistar ; Streptomyces - chemistry</subject><ispartof>The Journal of Antibiotics, 1993/06/25, Vol.46(6), pp.892-899</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-421d5548f1ac71324c079b696e53d9fe07a3779049afe58bba97d0ea4567803</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,4025,27927,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4887059$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8344870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KATO, SHINICHIRO</creatorcontrib><creatorcontrib>SHINDO, KAZUTOSHI</creatorcontrib><creatorcontrib>KAWAI, HIROYUKI</creatorcontrib><creatorcontrib>ODAGAWA, ATSUO</creatorcontrib><creatorcontrib>MATSUOKA, MICHIKO</creatorcontrib><creatorcontrib>MOCHIZUKI, JUNICHIRO</creatorcontrib><title>PYRROLOSTATIN, A NOVEL LIPID PEROXIDATION INHIBITOR FROM Streptomyces chrestomyceticus: TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Pyrrolostatin, a new lipid peroxidation inhibitor, was isolated from the culture of Streptomyces chrestomyceticus EC40. The structure was determined to be 4-geranylpyrrole-2-carboxylic acid on the basis of its spectroscopic and physico-chemical properties. Pyrrolostatin inhibited lipid peroxidation in rat brain homogenate.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Fermentation</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Hypoxia - prevention & control</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacology. Drug treatments</subject><subject>Proline - analogs & derivatives</subject><subject>Proline - chemistry</subject><subject>Proline - isolation & purification</subject><subject>Proline - pharmacology</subject><subject>Pyrroles - chemistry</subject><subject>Pyrroles - isolation & purification</subject><subject>Pyrroles - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Streptomyces - chemistry</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1O4zAUhS0Egg7wAkhIWSBWpNjx_7JAGSJCU6UVgpXluA4EpU2x0wVvP2ZSVezY2LLOd-85PgCcITjkiJFrverqsm672vghYUMhkz0wQEKgGBEm98EAwgTFQiTwCPzx_gNCzDEXh-BQYEIEhwPwPH0tijzLZ_PRPJ1cRaNokj-PsyhLp-ldNB0X-Ut6F6R8EqWTh_QmnedFdF_kT9Gsc3bdtcsvY31k3p31_SOk2fgTcFDpxtvT7X0MZvfj-e1DnOV_09tRFhvKky4mCVpQSkSFtOEIJ8RALksmmaV4ISsLucacS0ikriwVZaklX0CrCWVcQHwMLvuta9d-bkIAtay9sU2jV7bdeMWpRCL8-FcQcUgZpjKASQ8a13rvbKXWrl5q96UQVN-dqx-dK8JU6DwMnW-3b8qlXexGtiUH_WKra290Uzm9MrXfYUQE6L_3Y499-E6_2Z2uXTBr7E9nJJn4dmf9EULsKPOunbIr_A-IgaQP</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>KATO, SHINICHIRO</creator><creator>SHINDO, KAZUTOSHI</creator><creator>KAWAI, HIROYUKI</creator><creator>ODAGAWA, ATSUO</creator><creator>MATSUOKA, MICHIKO</creator><creator>MOCHIZUKI, JUNICHIRO</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>PYRROLOSTATIN, A NOVEL LIPID PEROXIDATION INHIBITOR FROM Streptomyces chrestomyceticus</title><author>KATO, SHINICHIRO ; SHINDO, KAZUTOSHI ; KAWAI, HIROYUKI ; ODAGAWA, ATSUO ; MATSUOKA, MICHIKO ; MOCHIZUKI, JUNICHIRO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-421d5548f1ac71324c079b696e53d9fe07a3779049afe58bba97d0ea4567803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Fermentation</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Hypoxia - prevention & control</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacology. Drug treatments</topic><topic>Proline - analogs & derivatives</topic><topic>Proline - chemistry</topic><topic>Proline - isolation & purification</topic><topic>Proline - pharmacology</topic><topic>Pyrroles - chemistry</topic><topic>Pyrroles - isolation & purification</topic><topic>Pyrroles - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Streptomyces - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KATO, SHINICHIRO</creatorcontrib><creatorcontrib>SHINDO, KAZUTOSHI</creatorcontrib><creatorcontrib>KAWAI, HIROYUKI</creatorcontrib><creatorcontrib>ODAGAWA, ATSUO</creatorcontrib><creatorcontrib>MATSUOKA, MICHIKO</creatorcontrib><creatorcontrib>MOCHIZUKI, JUNICHIRO</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KATO, SHINICHIRO</au><au>SHINDO, KAZUTOSHI</au><au>KAWAI, HIROYUKI</au><au>ODAGAWA, ATSUO</au><au>MATSUOKA, MICHIKO</au><au>MOCHIZUKI, JUNICHIRO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PYRROLOSTATIN, A NOVEL LIPID PEROXIDATION INHIBITOR FROM Streptomyces chrestomyceticus: TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1993</date><risdate>1993</risdate><volume>46</volume><issue>6</issue><spage>892</spage><epage>899</epage><pages>892-899</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Pyrrolostatin, a new lipid peroxidation inhibitor, was isolated from the culture of Streptomyces chrestomyceticus EC40. The structure was determined to be 4-geranylpyrrole-2-carboxylic acid on the basis of its spectroscopic and physico-chemical properties. Pyrrolostatin inhibited lipid peroxidation in rat brain homogenate.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>8344870</pmid><doi>10.7164/antibiotics.46.892</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1993/06/25, Vol.46(6), pp.892-899 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75918737 |
| source | J-STAGE Free; MEDLINE |
| subjects | Animals Biological and medical sciences Brain - drug effects Brain - metabolism Fermentation General and cellular metabolism. Vitamins Hypoxia - prevention & control Lipid Peroxidation - drug effects Male Medical sciences Mice Pharmacology. Drug treatments Proline - analogs & derivatives Proline - chemistry Proline - isolation & purification Proline - pharmacology Pyrroles - chemistry Pyrroles - isolation & purification Pyrroles - pharmacology Rats Rats, Wistar Streptomyces - chemistry |
| title | PYRROLOSTATIN, A NOVEL LIPID PEROXIDATION INHIBITOR FROM Streptomyces chrestomyceticus: TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES |
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