TETRAFIBRICIN, A NOVEL FIBRINOGEN RECEPTOR ANTAGONIST: I. TAXONOMY, FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES
Tetrafibricin is a novel fibrinogen receptor antagonist produced by Streptomyces neyagawaensis NR0577. It was isolated from the culture broth by Diaion HP-21 adsorption, MeOH extraction, MCI GEL CHP-20P column chromatography, preparative HPLC and Toyopearl HW-40 SF column chromatography. The physico...
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| Veröffentlicht in: | Journal of antibiotics 1993/07/25, Vol.46(7), pp.1039-1046 |
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| container_title | Journal of antibiotics |
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| creator | KAMIYAMA, TSUTOMU UMINO, TAKAYUKI FUJISAKI, NORIKO FUJIMORI, KUMIKO SATOH, TOMOKO YAMASHITA, YUKO OHSHIMA, SHOICHI WATANABE, JUNKO YOKOSE, KAZUTERU |
| description | Tetrafibricin is a novel fibrinogen receptor antagonist produced by Streptomyces neyagawaensis NR0577. It was isolated from the culture broth by Diaion HP-21 adsorption, MeOH extraction, MCI GEL CHP-20P column chromatography, preparative HPLC and Toyopearl HW-40 SF column chromatography. The physico-chemical properties of tetrafibricin indicated that the structure of tetrafibricin is different from the known peptide fibrinogen receptor antagonists and closely related to the polyene macrolide antibiotics. Tetrafibricin strongly inhibited the binding of fibrinogen to its receptors with an IC50 of 46 nM. It also inhibited ADP-, collagen-, and thrombin-induced aggregation of human platelets with IC50s of 5.6, 11.0 and 7.6μM, respectively. |
| doi_str_mv | 10.7164/antibiotics.46.1039 |
| format | Article |
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Psychology ; Humans ; In Vitro Techniques ; Macrolides ; Microbiology ; Platelet Membrane Glycoproteins - antagonists & inhibitors ; Streptomyces - classification ; Streptomyces - metabolism</subject><ispartof>The Journal of Antibiotics, 1993/07/25, Vol.46(7), pp.1039-1046</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4609-868db4e3a9330d9344b8c711ab790b16b0513e44d7e632251a1864cd9d7eb5cb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4881645$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8360097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAMIYAMA, TSUTOMU</creatorcontrib><creatorcontrib>UMINO, TAKAYUKI</creatorcontrib><creatorcontrib>FUJISAKI, NORIKO</creatorcontrib><creatorcontrib>FUJIMORI, KUMIKO</creatorcontrib><creatorcontrib>SATOH, TOMOKO</creatorcontrib><creatorcontrib>YAMASHITA, YUKO</creatorcontrib><creatorcontrib>OHSHIMA, SHOICHI</creatorcontrib><creatorcontrib>WATANABE, JUNKO</creatorcontrib><creatorcontrib>YOKOSE, KAZUTERU</creatorcontrib><title>TETRAFIBRICIN, A NOVEL FIBRINOGEN RECEPTOR ANTAGONIST: I. TAXONOMY, FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Tetrafibricin is a novel fibrinogen receptor antagonist produced by Streptomyces neyagawaensis NR0577. It was isolated from the culture broth by Diaion HP-21 adsorption, MeOH extraction, MCI GEL CHP-20P column chromatography, preparative HPLC and Toyopearl HW-40 SF column chromatography. The physico-chemical properties of tetrafibricin indicated that the structure of tetrafibricin is different from the known peptide fibrinogen receptor antagonists and closely related to the polyene macrolide antibiotics. Tetrafibricin strongly inhibited the binding of fibrinogen to its receptors with an IC50 of 46 nM. It also inhibited ADP-, collagen-, and thrombin-induced aggregation of human platelets with IC50s of 5.6, 11.0 and 7.6μM, respectively.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Chemotherapic agents</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Macrolides</subject><subject>Microbiology</subject><subject>Platelet Membrane Glycoproteins - antagonists & inhibitors</subject><subject>Streptomyces - classification</subject><subject>Streptomyces - metabolism</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF9PwjAUxRujQUQ_gTHZg_HJYS_t-udxkoFLyGZw-tq0XdGRAbqOB7-9Qwjh5d7knt-9pz0I3QIecmD0Sa_bylSbtrJ-SNkQMJFnqA9CQAiUyXPUx3gEoRAjfImuvF9iTDjhood6gjCMJe-jqEiKeTxJn-fpOM0egzjI8o9kFvxPsnyaZME8GSevRT4P4qyIp3mWvhXX6GKha-9uDn2A3idJMX4JZ_k0Hcez0FKGZSiYKA11REtCcCkJpUZYDqANl9gAMzgC4igtuWNkNIpAg2DUlrIbmMgaMkAP-7vfzeZn63yrVpW3rq712m22XvFIQvcj6ECyB22z8b5xC_XdVCvd_CrAaheWOglLUaZ2YXVbd4fzW7Ny5XHnkE6n3x907a2uF41e28ofMdolzWjUYbM9tvSt_nRHXTedW-1OrUEysbPn-7J7xRGzX7pRbk3-AMwDilU</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>KAMIYAMA, TSUTOMU</creator><creator>UMINO, TAKAYUKI</creator><creator>FUJISAKI, NORIKO</creator><creator>FUJIMORI, KUMIKO</creator><creator>SATOH, TOMOKO</creator><creator>YAMASHITA, YUKO</creator><creator>OHSHIMA, SHOICHI</creator><creator>WATANABE, JUNKO</creator><creator>YOKOSE, KAZUTERU</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>TETRAFIBRICIN, A NOVEL FIBRINOGEN RECEPTOR ANTAGONIST</title><author>KAMIYAMA, TSUTOMU ; UMINO, TAKAYUKI ; FUJISAKI, NORIKO ; FUJIMORI, KUMIKO ; SATOH, TOMOKO ; YAMASHITA, YUKO ; OHSHIMA, SHOICHI ; WATANABE, JUNKO ; YOKOSE, KAZUTERU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4609-868db4e3a9330d9344b8c711ab790b16b0513e44d7e632251a1864cd9d7eb5cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Chemotherapic agents</topic><topic>Fermentation</topic><topic>Fundamental and applied biological sciences. 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TAXONOMY, FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1993</date><risdate>1993</risdate><volume>46</volume><issue>7</issue><spage>1039</spage><epage>1046</epage><pages>1039-1046</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Tetrafibricin is a novel fibrinogen receptor antagonist produced by Streptomyces neyagawaensis NR0577. It was isolated from the culture broth by Diaion HP-21 adsorption, MeOH extraction, MCI GEL CHP-20P column chromatography, preparative HPLC and Toyopearl HW-40 SF column chromatography. The physico-chemical properties of tetrafibricin indicated that the structure of tetrafibricin is different from the known peptide fibrinogen receptor antagonists and closely related to the polyene macrolide antibiotics. Tetrafibricin strongly inhibited the binding of fibrinogen to its receptors with an IC50 of 46 nM. 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| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1993/07/25, Vol.46(7), pp.1039-1046 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75917371 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Chemical Phenomena Chemistry, Physical Chemotherapic agents Fermentation Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Macrolides Microbiology Platelet Membrane Glycoproteins - antagonists & inhibitors Streptomyces - classification Streptomyces - metabolism |
| title | TETRAFIBRICIN, A NOVEL FIBRINOGEN RECEPTOR ANTAGONIST: I. TAXONOMY, FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES |
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