Enhancement of LAK-like activity and cytokine induction in regional lymph nodes and spleen cells of mice after intralymphnodal injection of OK-432, a killed streptococcal preparation

A single dose of inactivated streptococci (OK-432) was injected into the popliteal lymph nodes of male CDF1, mice and its effects on popliteal, inguinal, and para-aortic lymph node cells and spleen cells were investigated and compared with the effects of subcutaneous injections of the same dosage of...

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Veröffentlicht in:	Anti-cancer drugs 1993-06, Vol.4 (3), p.381-388
Hauptverfasser:	Sakakura, Chouhei, Takahashi, Toshio, Hagiwara, Akeo, Yamane, Tetsuro, Sawai, Seiji, Okano, Shinji, Ozaki, Kimihiko, Sasaki, Sadayuki, Tsujimoto, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Complement System Proteins - pharmacology Cytokines - biosynthesis Cytotoxicity, Immunologic Injections, Intralymphatic Killer Cells, Lymphokine-Activated - drug effects Killer Cells, Lymphokine-Activated - immunology Killer Cells, Lymphokine-Activated - physiology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Killer Cells, Natural - physiology Lymph Nodes - drug effects Lymph Nodes - immunology Lymph Nodes - metabolism Male Mice Mice, Inbred Strains Neoplasms, Experimental - drug therapy Neoplasms, Experimental - immunology Neoplasms, Experimental - metabolism Picibanil - pharmacology Sensitivity and Specificity Spleen - drug effects Spleen - immunology Spleen - metabolism Time Factors
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