Dibutyryl cyclic adenosine monophosphate differentially regulates cell proliferation in low and high alkaline phosphatase SaOS-2 human osteosarcoma cells: Evidence for mediation by the insulin-like growth factor-II system

In the present study, we have sought to determine whether a given signal transduction pathway can have diverse effects on subpopulations of cells of a lineage depending upon the stage of differentiation. To test this hypothesis, we selected the cyclic adenosine monophosphate (cAMP) signal transducti...

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Veröffentlicht in:	Journal of cellular physiology 1993-09, Vol.156 (3), p.462-468
Hauptverfasser:	Mohan, S., Strong, D. D., Hilliker, S., Malpe, R., Lee, K., Farley, J., Baylink, D. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Biological and medical sciences Bucladesine - pharmacology Carrier Proteins - genetics Cell cycle, cell proliferation Cell Division - drug effects Cell physiology Culture Media Fundamental and applied biological sciences. Psychology Humans Insulin-Like Growth Factor Binding Proteins Insulin-Like Growth Factor II - genetics Insulin-Like Growth Factor II - metabolism Insulin-Like Growth Factor II - physiology Molecular and cellular biology Osteosarcoma - enzymology Osteosarcoma - pathology Phenotype RNA, Messenger - metabolism Tumor Cells, Cultured
Online-Zugang:	Volltext
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