An elevated hematogenous photosensitizer in the preterm neonate
Human blood contains low levels of protoporphyrin IX (PP IX), a photoactive compound that produces reactive oxygen species when exposed to light. It has been proposed that photoactivation of PP IX and subsequent generation of potentially tissue-damaging reactive oxygen may be a mechanism of retinal...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 1993-09, Vol.34 (10), p.2878-2880 |
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| creator | Bynoe, LA Gottsch, JD Sadda, SR Panton, RW Haller, EM Gleason, CA |
| description | Human blood contains low levels of protoporphyrin IX (PP IX), a photoactive compound that produces reactive oxygen species when exposed to light. It has been proposed that photoactivation of PP IX and subsequent generation of potentially tissue-damaging reactive oxygen may be a mechanism of retinal injury in retinopathy of prematurity (ROP). The purpose of this study is to determine an association between blood PP IX level and infant birth-weight and gestational age.
Erythrocyte PP IX levels were measured from the umbilical cord blood of 31 neonates, both full term and preterm. Birthweights and gestational ages were recorded.
PP IX levels in infants weighing < 1000 grams (n = 7) average 200 micrograms/dl, which is significantly higher than PP IX levels in infants weighing > 1000 grams (125 micrograms/dl, n = 24; P < 0.02).
Elevated PP IX levels may place preterm neonates at increased risk for photosensitizing retinal injury. |
| format | Article |
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Erythrocyte PP IX levels were measured from the umbilical cord blood of 31 neonates, both full term and preterm. Birthweights and gestational ages were recorded.
PP IX levels in infants weighing < 1000 grams (n = 7) average 200 micrograms/dl, which is significantly higher than PP IX levels in infants weighing > 1000 grams (125 micrograms/dl, n = 24; P < 0.02).
Elevated PP IX levels may place preterm neonates at increased risk for photosensitizing retinal injury.</description><identifier>ISSN: 0146-0404</identifier><identifier>EISSN: 1552-5783</identifier><identifier>PMID: 8360020</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Biological and medical sciences ; Fetal Blood - chemistry ; Gestational Age ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature - blood ; Medical sciences ; Ophthalmology ; Protoporphyrins - blood ; Retinopathies ; Retinopathy of Prematurity - etiology ; Risk Factors ; Umbilical Cord - blood supply</subject><ispartof>Investigative ophthalmology & visual science, 1993-09, Vol.34 (10), p.2878-2880</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4900195$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8360020$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bynoe, LA</creatorcontrib><creatorcontrib>Gottsch, JD</creatorcontrib><creatorcontrib>Sadda, SR</creatorcontrib><creatorcontrib>Panton, RW</creatorcontrib><creatorcontrib>Haller, EM</creatorcontrib><creatorcontrib>Gleason, CA</creatorcontrib><title>An elevated hematogenous photosensitizer in the preterm neonate</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>Human blood contains low levels of protoporphyrin IX (PP IX), a photoactive compound that produces reactive oxygen species when exposed to light. It has been proposed that photoactivation of PP IX and subsequent generation of potentially tissue-damaging reactive oxygen may be a mechanism of retinal injury in retinopathy of prematurity (ROP). The purpose of this study is to determine an association between blood PP IX level and infant birth-weight and gestational age.
Erythrocyte PP IX levels were measured from the umbilical cord blood of 31 neonates, both full term and preterm. Birthweights and gestational ages were recorded.
PP IX levels in infants weighing < 1000 grams (n = 7) average 200 micrograms/dl, which is significantly higher than PP IX levels in infants weighing > 1000 grams (125 micrograms/dl, n = 24; P < 0.02).
Elevated PP IX levels may place preterm neonates at increased risk for photosensitizing retinal injury.</description><subject>Biological and medical sciences</subject><subject>Fetal Blood - chemistry</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - blood</subject><subject>Medical sciences</subject><subject>Ophthalmology</subject><subject>Protoporphyrins - blood</subject><subject>Retinopathies</subject><subject>Retinopathy of Prematurity - etiology</subject><subject>Risk Factors</subject><subject>Umbilical Cord - blood supply</subject><issn>0146-0404</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LxDAQhoMo67r6E4QcRE-FfLbpSZbFL1jwoueQNtNtpF8mqUV_vZUtnobhfeZhZk7QmkrJEpkpforWhIo0IYKIc3QRwgchjFJGVmileDo3ZI3utx2GBr5MBItraE3sD9D1Y8BD3cc-QBdcdD_gsetwrAEPHiL4FnfQd_PQJTqrTBPgaqkb9P748LZ7TvavTy-77T6pWZrFJONc8tIyWpWVUMIIVQFXwoLihiipCsmKEqxQUNA0zUFaaa2yqSisIVQSvkG3R-_g-88RQtStCyU0jZkXGYPOZE6FUnIGrxdwLFqwevCuNf5bLxfP-c2Sm1CapvKmK134x0ROCM3_NHdHrHaHenIedGhN08xSqqdp4kJTopma3_wL2TlteA</recordid><startdate>19930901</startdate><enddate>19930901</enddate><creator>Bynoe, LA</creator><creator>Gottsch, JD</creator><creator>Sadda, SR</creator><creator>Panton, RW</creator><creator>Haller, EM</creator><creator>Gleason, CA</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19930901</creationdate><title>An elevated hematogenous photosensitizer in the preterm neonate</title><author>Bynoe, LA ; Gottsch, JD ; Sadda, SR ; Panton, RW ; Haller, EM ; Gleason, CA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h267t-73353cd21fcf484a48fe384de83a0858b52bced48eb1669e5d5dd8d64bda01503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Biological and medical sciences</topic><topic>Fetal Blood - chemistry</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - blood</topic><topic>Medical sciences</topic><topic>Ophthalmology</topic><topic>Protoporphyrins - blood</topic><topic>Retinopathies</topic><topic>Retinopathy of Prematurity - etiology</topic><topic>Risk Factors</topic><topic>Umbilical Cord - blood supply</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bynoe, LA</creatorcontrib><creatorcontrib>Gottsch, JD</creatorcontrib><creatorcontrib>Sadda, SR</creatorcontrib><creatorcontrib>Panton, RW</creatorcontrib><creatorcontrib>Haller, EM</creatorcontrib><creatorcontrib>Gleason, CA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bynoe, LA</au><au>Gottsch, JD</au><au>Sadda, SR</au><au>Panton, RW</au><au>Haller, EM</au><au>Gleason, CA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An elevated hematogenous photosensitizer in the preterm neonate</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>1993-09-01</date><risdate>1993</risdate><volume>34</volume><issue>10</issue><spage>2878</spage><epage>2880</epage><pages>2878-2880</pages><issn>0146-0404</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>Human blood contains low levels of protoporphyrin IX (PP IX), a photoactive compound that produces reactive oxygen species when exposed to light. It has been proposed that photoactivation of PP IX and subsequent generation of potentially tissue-damaging reactive oxygen may be a mechanism of retinal injury in retinopathy of prematurity (ROP). The purpose of this study is to determine an association between blood PP IX level and infant birth-weight and gestational age.
Erythrocyte PP IX levels were measured from the umbilical cord blood of 31 neonates, both full term and preterm. Birthweights and gestational ages were recorded.
PP IX levels in infants weighing < 1000 grams (n = 7) average 200 micrograms/dl, which is significantly higher than PP IX levels in infants weighing > 1000 grams (125 micrograms/dl, n = 24; P < 0.02).
Elevated PP IX levels may place preterm neonates at increased risk for photosensitizing retinal injury.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>8360020</pmid><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0146-0404 |
| ispartof | Investigative ophthalmology & visual science, 1993-09, Vol.34 (10), p.2878-2880 |
| issn | 0146-0404 1552-5783 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Fetal Blood - chemistry Gestational Age Humans Infant, Low Birth Weight Infant, Newborn Infant, Premature - blood Medical sciences Ophthalmology Protoporphyrins - blood Retinopathies Retinopathy of Prematurity - etiology Risk Factors Umbilical Cord - blood supply |
| title | An elevated hematogenous photosensitizer in the preterm neonate |
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