Effect of the myotonic dystrophy (DM) mutation on mRNA levels of the DM gene

Myotonic dystrophy (DM) results from the amplification of an unstable CTG repeat in the 3′ untranslated region of a transcript encoding a putative serine/threonine kinase. We have analysed the amplification of the repeat and the steady state levels of the DM kinase (DMK) mRNA in tissues and cell lin...

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Veröffentlicht in:	Nature genetics 1993-07, Vol.4 (3), p.233-238
Hauptverfasser:	Sabouri, Luc A, Mahadevan, Mani S, Narang, Monica, Lee, David S.C, Surh, Linda C, Korneluk, Robert G
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Alleles Animal Genetics and Genomics Base Sequence Biomedical and Life Sciences Biomedicine Cancer Research DNA - genetics effects on Gene Amplification Gene Expression Gene Function genes Genes, Dominant Human Genetics Humans Infant, Newborn levels man Molecular Sequence Data mRNA Mutation myotonic dystrophy Myotonic Dystrophy - congenital Myotonic Dystrophy - genetics Myotonic Dystrophy - metabolism Oligodeoxyribonucleotides - genetics Protein-Serine-Threonine Kinases - genetics Repetitive Sequences, Nucleic Acid RNA, Messenger - genetics RNA, Messenger - metabolism
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