Total Synthesis of Berkelic Acid

A productive total synthesis of both enantiomers of berkelic acid (1) is outlined that takes the structure revision of this bioactive fungal metabolite previously proposed by our group into account. The successful route relies on a fully optimized triple‐deprotection/1,4‐addition/spiroacetalization...

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Veröffentlicht in:	Chemistry : a European journal 2010-10, Vol.16 (40), p.12133-12140
Hauptverfasser:	Snaddon, Thomas N., Buchgraber, Philipp, Schulthoff, Saskia, Wirtz, Conny, Mynott, Richard, Fürstner, Alois
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Aliphatic compounds Anticancer agents Chains Chemistry Cyclization Derivatives enzyme inhibitors Esters Fungi Metabolites Molecular Structure natural products Oxidation-Reduction spiro compounds Spiro Compounds - chemical synthesis Spiro Compounds - chemistry Stereoisomerism Synthesis total synthesis
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