Scintigraphic assessment of salivary gland function in a rat model
Salivary gland dysfunction with xerostomia is a major clinical problem without a causal therapy in most cases. The development of an animal model for scintigraphic assessment of salivary gland function has great clinical relevance for the investigation of promising new diagnostic and therapeutic str...
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| Veröffentlicht in: | In vivo (Athens) 2010-09, Vol.24 (5), p.681-685 |
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| container_title | In vivo (Athens) |
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| creator | Pfestroff, Andreas Müller, Felix Librizzi, Damiano Eivazi, Behfar Behe, Martin Hoeffken, Helmut Behr, Thomas M Teymoortash, Afshin |
| description | Salivary gland dysfunction with xerostomia is a major clinical problem without a causal therapy in most cases. The development of an animal model for scintigraphic assessment of salivary gland function has great clinical relevance for the investigation of promising new diagnostic and therapeutic strategies for chronic salivary gland diseases. This study reports the first experiences with scintigraphic analyses of salivary gland function in a rat model.
Anatomical and scintigraphic studies were performed for topographic differentiation of major salivary glands of Wistar rats. (⁹⁹m)technetium pertechnetate salivary gland scanning was performed, appropriate regions of interest were determined and the gland-to-background ratio was examined for the evaluation of salivary gland function.
The quantitative analysis of salivary gland scintigraphy revealed a reliable comparison of major salivary glands on both sides with the gland-to-background ratio ranging from 1.26 to 1.94 with an average of 1.51.
This model seems to be appropriate for functional studies in an experimental setting. |
| format | Article |
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Anatomical and scintigraphic studies were performed for topographic differentiation of major salivary glands of Wistar rats. (⁹⁹m)technetium pertechnetate salivary gland scanning was performed, appropriate regions of interest were determined and the gland-to-background ratio was examined for the evaluation of salivary gland function.
The quantitative analysis of salivary gland scintigraphy revealed a reliable comparison of major salivary glands on both sides with the gland-to-background ratio ranging from 1.26 to 1.94 with an average of 1.51.
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Anatomical and scintigraphic studies were performed for topographic differentiation of major salivary glands of Wistar rats. (⁹⁹m)technetium pertechnetate salivary gland scanning was performed, appropriate regions of interest were determined and the gland-to-background ratio was examined for the evaluation of salivary gland function.
The quantitative analysis of salivary gland scintigraphy revealed a reliable comparison of major salivary glands on both sides with the gland-to-background ratio ranging from 1.26 to 1.94 with an average of 1.51.
This model seems to be appropriate for functional studies in an experimental setting.</description><subject>Animals</subject><subject>Chronic Disease</subject><subject>Disease Models, Animal</subject><subject>Male</subject><subject>Parotid Gland - diagnostic imaging</subject><subject>Radionuclide Imaging - methods</subject><subject>Radiopharmaceuticals</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Salivary Glands - diagnostic imaging</subject><subject>Sodium Pertechnetate Tc 99m</subject><subject>Sublingual Gland - diagnostic imaging</subject><subject>Submandibular Gland - diagnostic imaging</subject><subject>Xerostomia - diagnostic imaging</subject><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j81KxDAURoMgzjj6CpKdq8JNmzSTpQ7-wYALdV3S3GSMtGntTQXf3oIzq29z-DjnjK2FNqLQSpoVuyT6Aqg1QHnBViUYVeqqWrP7NxdTjofJjp_RcUvkiXqfMh8CJ9vFHzv98kNnE_IwJ5fjkHhM3PLJZt4P6Lsrdh5sR_76uBv28fjwvnsu9q9PL7u7fTGWAnLhW5DKeedUkBhcHbD0WighnTSIWoS6lQaEtRj0tg5Og0RjoAWLiHIrqg27_f8dp-F79pSbPpLz3eLmh5karYyohAC1kDdHcm57j804xX7JaE7Z1R9bIlOv</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Pfestroff, Andreas</creator><creator>Müller, Felix</creator><creator>Librizzi, Damiano</creator><creator>Eivazi, Behfar</creator><creator>Behe, Martin</creator><creator>Hoeffken, Helmut</creator><creator>Behr, Thomas M</creator><creator>Teymoortash, Afshin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20100901</creationdate><title>Scintigraphic assessment of salivary gland function in a rat model</title><author>Pfestroff, Andreas ; Müller, Felix ; Librizzi, Damiano ; Eivazi, Behfar ; Behe, Martin ; Hoeffken, Helmut ; Behr, Thomas M ; Teymoortash, Afshin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p210t-eb045cecc5f4dfc6fd2e71514c49dd71f6b4901aadf786fc704d990b0addd4813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Chronic Disease</topic><topic>Disease Models, Animal</topic><topic>Male</topic><topic>Parotid Gland - diagnostic imaging</topic><topic>Radionuclide Imaging - methods</topic><topic>Radiopharmaceuticals</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Salivary Glands - diagnostic imaging</topic><topic>Sodium Pertechnetate Tc 99m</topic><topic>Sublingual Gland - diagnostic imaging</topic><topic>Submandibular Gland - diagnostic imaging</topic><topic>Xerostomia - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pfestroff, Andreas</creatorcontrib><creatorcontrib>Müller, Felix</creatorcontrib><creatorcontrib>Librizzi, Damiano</creatorcontrib><creatorcontrib>Eivazi, Behfar</creatorcontrib><creatorcontrib>Behe, Martin</creatorcontrib><creatorcontrib>Hoeffken, Helmut</creatorcontrib><creatorcontrib>Behr, Thomas M</creatorcontrib><creatorcontrib>Teymoortash, Afshin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pfestroff, Andreas</au><au>Müller, Felix</au><au>Librizzi, Damiano</au><au>Eivazi, Behfar</au><au>Behe, Martin</au><au>Hoeffken, Helmut</au><au>Behr, Thomas M</au><au>Teymoortash, Afshin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scintigraphic assessment of salivary gland function in a rat model</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>24</volume><issue>5</issue><spage>681</spage><epage>685</epage><pages>681-685</pages><eissn>1791-7549</eissn><abstract>Salivary gland dysfunction with xerostomia is a major clinical problem without a causal therapy in most cases. The development of an animal model for scintigraphic assessment of salivary gland function has great clinical relevance for the investigation of promising new diagnostic and therapeutic strategies for chronic salivary gland diseases. This study reports the first experiences with scintigraphic analyses of salivary gland function in a rat model.
Anatomical and scintigraphic studies were performed for topographic differentiation of major salivary glands of Wistar rats. (⁹⁹m)technetium pertechnetate salivary gland scanning was performed, appropriate regions of interest were determined and the gland-to-background ratio was examined for the evaluation of salivary gland function.
The quantitative analysis of salivary gland scintigraphy revealed a reliable comparison of major salivary glands on both sides with the gland-to-background ratio ranging from 1.26 to 1.94 with an average of 1.51.
This model seems to be appropriate for functional studies in an experimental setting.</abstract><cop>Greece</cop><pmid>20952733</pmid><tpages>5</tpages></addata></record> |
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| ispartof | In vivo (Athens), 2010-09, Vol.24 (5), p.681-685 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Chronic Disease Disease Models, Animal Male Parotid Gland - diagnostic imaging Radionuclide Imaging - methods Radiopharmaceuticals Rats Rats, Wistar Salivary Glands - diagnostic imaging Sodium Pertechnetate Tc 99m Sublingual Gland - diagnostic imaging Submandibular Gland - diagnostic imaging Xerostomia - diagnostic imaging |
| title | Scintigraphic assessment of salivary gland function in a rat model |
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