Sympathetic innervation of lymph nodes in mice
Noradrenergic innervation of popliteal and mesenteric lymph nodes in mice was examined with fluorescence histochemistry. Dense varicose plexuses entered the nodes with the vasculature in the hilar region and continued with the vasculature into the medullary region. Fine, delicate varicosities and sm...
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| Veröffentlicht in: | Brain research bulletin 1984-12, Vol.13 (6), p.693-699 |
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| container_title | Brain research bulletin |
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| creator | Felten, David L. Livnat, Shmuel Felten, Suzanne Y. Carlson, Sonia L. Bellinger, Denise Lorton Yeh, Pamela |
| description | Noradrenergic innervation of popliteal and mesenteric lymph nodes in mice was examined with fluorescence histochemistry. Dense varicose plexuses entered the nodes with the vasculature in the hilar region and continued with the vasculature into the medullary region. Fine, delicate varicosities and small vascular plexuses continued into the cortical and paracortical regions surrounding the germinal centers; some varicosities ended among lymphocytes. A subcapsular plexus contributed fibers into the cortical and paracortical regions. Chemical measurements revealed the presence of norepinephrine in lymph nodes that was deptetable with 6-hydroxydopamine. Depletion of norepinephrine from lymph nodes with this agent resulted in a diminished primary immune response in draining lymph nodes following subcutaneous injection of an antigen in two mouse strains, but had no effect in two other strains. These findings suggest that noradrenergic fibers innervate both the vasculature and parenchymal regions of lymph nodes, and may participate in the modulation of immune responses in these organs. |
| doi_str_mv | 10.1016/0361-9230(84)90230-2 |
| format | Article |
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Dense varicose plexuses entered the nodes with the vasculature in the hilar region and continued with the vasculature into the medullary region. Fine, delicate varicosities and small vascular plexuses continued into the cortical and paracortical regions surrounding the germinal centers; some varicosities ended among lymphocytes. A subcapsular plexus contributed fibers into the cortical and paracortical regions. Chemical measurements revealed the presence of norepinephrine in lymph nodes that was deptetable with 6-hydroxydopamine. Depletion of norepinephrine from lymph nodes with this agent resulted in a diminished primary immune response in draining lymph nodes following subcutaneous injection of an antigen in two mouse strains, but had no effect in two other strains. These findings suggest that noradrenergic fibers innervate both the vasculature and parenchymal regions of lymph nodes, and may participate in the modulation of immune responses in these organs.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/0361-9230(84)90230-2</identifier><identifier>PMID: 6532515</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adrenergic Fibers - anatomy & histology ; Animals ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Lymph nodes ; Lymph Nodes - innervation ; Lymphatic system ; Lymphocytes ; Male ; Mice ; Mice, Inbred Strains ; Microscopy, Fluorescence ; Norepinephrine ; Norepinephrine - metabolism ; Species Specificity ; Strain differences ; Sympathetic innervation ; Vertebrates: cardiovascular system</subject><ispartof>Brain research bulletin, 1984-12, Vol.13 (6), p.693-699</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-ea7456c3fc942e996da2588b508b334ff4de34feb2cded014f8da0381595f1d63</citedby><cites>FETCH-LOGICAL-c483t-ea7456c3fc942e996da2588b508b334ff4de34feb2cded014f8da0381595f1d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0361-9230(84)90230-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9130431$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6532515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Felten, David L.</creatorcontrib><creatorcontrib>Livnat, Shmuel</creatorcontrib><creatorcontrib>Felten, Suzanne Y.</creatorcontrib><creatorcontrib>Carlson, Sonia L.</creatorcontrib><creatorcontrib>Bellinger, Denise Lorton</creatorcontrib><creatorcontrib>Yeh, Pamela</creatorcontrib><title>Sympathetic innervation of lymph nodes in mice</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>Noradrenergic innervation of popliteal and mesenteric lymph nodes in mice was examined with fluorescence histochemistry. Dense varicose plexuses entered the nodes with the vasculature in the hilar region and continued with the vasculature into the medullary region. Fine, delicate varicosities and small vascular plexuses continued into the cortical and paracortical regions surrounding the germinal centers; some varicosities ended among lymphocytes. A subcapsular plexus contributed fibers into the cortical and paracortical regions. Chemical measurements revealed the presence of norepinephrine in lymph nodes that was deptetable with 6-hydroxydopamine. Depletion of norepinephrine from lymph nodes with this agent resulted in a diminished primary immune response in draining lymph nodes following subcutaneous injection of an antigen in two mouse strains, but had no effect in two other strains. These findings suggest that noradrenergic fibers innervate both the vasculature and parenchymal regions of lymph nodes, and may participate in the modulation of immune responses in these organs.</description><subject>Adrenergic Fibers - anatomy & histology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - innervation</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Microscopy, Fluorescence</subject><subject>Norepinephrine</subject><subject>Norepinephrine - metabolism</subject><subject>Species Specificity</subject><subject>Strain differences</subject><subject>Sympathetic innervation</subject><subject>Vertebrates: cardiovascular system</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKBDEQRYMoOj7-QKEXIrpozbuTjSCDLxBcqOuQSSoY6ceY9Aj-vRlnmKWuquCeWxQHoWOCLwkm8gozSWpNGT5X_ELjstR0C02IalhNG95so8kG2UP7OX9gjKUSchftSsGoIGKCLl--u7kd32GMrop9D-nLjnHoqyFUbYneq37wkEtUddHBIdoJts1wtJ4H6O3u9nX6UD893z9Ob55qxxUba7ANF9Kx4DSnoLX0lgqlZgKrGWM8BO6hDJhR58FjwoPyFjNFhBaBeMkO0Nnq7jwNnwvIo-lidtC2todhkU0jNKEE839BwolmSuoC8hXo0pBzgmDmKXY2fRuCzdKnWcoyS1lGcfPr09BSO1nfX8w68JvSWmDJT9e5zc62IdnexbzBNGHlSVKw6xUGRdpXhGSyi9A78DGBG40f4t9__ACjXI-S</recordid><startdate>198412</startdate><enddate>198412</enddate><creator>Felten, David L.</creator><creator>Livnat, Shmuel</creator><creator>Felten, Suzanne Y.</creator><creator>Carlson, Sonia L.</creator><creator>Bellinger, Denise Lorton</creator><creator>Yeh, Pamela</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>198412</creationdate><title>Sympathetic innervation of lymph nodes in mice</title><author>Felten, David L. ; Livnat, Shmuel ; Felten, Suzanne Y. ; Carlson, Sonia L. ; Bellinger, Denise Lorton ; Yeh, Pamela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-ea7456c3fc942e996da2588b508b334ff4de34feb2cded014f8da0381595f1d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adrenergic Fibers - anatomy & histology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - innervation</topic><topic>Lymphatic system</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Microscopy, Fluorescence</topic><topic>Norepinephrine</topic><topic>Norepinephrine - metabolism</topic><topic>Species Specificity</topic><topic>Strain differences</topic><topic>Sympathetic innervation</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Felten, David L.</creatorcontrib><creatorcontrib>Livnat, Shmuel</creatorcontrib><creatorcontrib>Felten, Suzanne Y.</creatorcontrib><creatorcontrib>Carlson, Sonia L.</creatorcontrib><creatorcontrib>Bellinger, Denise Lorton</creatorcontrib><creatorcontrib>Yeh, Pamela</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Felten, David L.</au><au>Livnat, Shmuel</au><au>Felten, Suzanne Y.</au><au>Carlson, Sonia L.</au><au>Bellinger, Denise Lorton</au><au>Yeh, Pamela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sympathetic innervation of lymph nodes in mice</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1984-12</date><risdate>1984</risdate><volume>13</volume><issue>6</issue><spage>693</spage><epage>699</epage><pages>693-699</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>Noradrenergic innervation of popliteal and mesenteric lymph nodes in mice was examined with fluorescence histochemistry. Dense varicose plexuses entered the nodes with the vasculature in the hilar region and continued with the vasculature into the medullary region. Fine, delicate varicosities and small vascular plexuses continued into the cortical and paracortical regions surrounding the germinal centers; some varicosities ended among lymphocytes. A subcapsular plexus contributed fibers into the cortical and paracortical regions. Chemical measurements revealed the presence of norepinephrine in lymph nodes that was deptetable with 6-hydroxydopamine. Depletion of norepinephrine from lymph nodes with this agent resulted in a diminished primary immune response in draining lymph nodes following subcutaneous injection of an antigen in two mouse strains, but had no effect in two other strains. These findings suggest that noradrenergic fibers innervate both the vasculature and parenchymal regions of lymph nodes, and may participate in the modulation of immune responses in these organs.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6532515</pmid><doi>10.1016/0361-9230(84)90230-2</doi><tpages>7</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adrenergic Fibers - anatomy & histology Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Lymph nodes Lymph Nodes - innervation Lymphatic system Lymphocytes Male Mice Mice, Inbred Strains Microscopy, Fluorescence Norepinephrine Norepinephrine - metabolism Species Specificity Strain differences Sympathetic innervation Vertebrates: cardiovascular system |
| title | Sympathetic innervation of lymph nodes in mice |
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