Metrazole induces the sequential activation of c-fos, proenkephalin, and tyrosine hydroxylase gene expression in the rat adrenal gland: modulation by glucocorticoid and adrenocorticotropic hormone

The immediate-early gene c-fos (a nuclear transcription factor) has been viewed as a nuclear "third messenger" or cellular "master switch." Both in vitro and in vivo studies have suggested that the proenkephalin (Penk) and tyrosine hydroxylase (TH) genes are potential targets of...

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Veröffentlicht in:	Molecular pharmacology 1993-08, Vol.44 (2), p.328-335
Hauptverfasser:	Zhu, Y S, Brodsky, M, Franklin, S O, Huang, T, Inturrisi, C E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - drug effects Adrenal Glands - metabolism Adrenocorticotropic Hormone - pharmacology Animals Biological and medical sciences Dose-Response Relationship, Drug Enkephalins - biosynthesis Enkephalins - genetics Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - drug effects Genes, fos - drug effects Glucocorticoids - physiology Hippocampus - drug effects Hippocampus - metabolism Hypophysectomy Immunohistochemistry Male Molecular and cellular biology Molecular genetics Pentylenetetrazole - pharmacology Protein Precursors - biosynthesis Protein Precursors - genetics Rats Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Transcription, Genetic Tyrosine 3-Monooxygenase - biosynthesis Tyrosine 3-Monooxygenase - genetics
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