Short-chain fatty acids in the proximal gastrointestinal tract of healthy subjects
The total concentration of short-chain fatty acids (SCFAs) in healthy subjects, measured by gas chromatography, was in saliva and jejunal aspirates (n = 6) (median (range] 4480 (2780-9940) mumol/l and 265 (185-1470) mumol/l and in gastric and duodenal aspirates (n = 7) 719 (425-1770) mumol/l and 480...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1984-11, Vol.19 (8), p.1053-1058 |
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| container_title | Scandinavian journal of gastroenterology |
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| creator | HØVERSTAD, T BJØRNEKLETT, A MIDTVEDT, T FAUSA, O BØHMER, T |
| description | The total concentration of short-chain fatty acids (SCFAs) in healthy subjects, measured by gas chromatography, was in saliva and jejunal aspirates (n = 6) (median (range] 4480 (2780-9940) mumol/l and 265 (185-1470) mumol/l and in gastric and duodenal aspirates (n = 7) 719 (425-1770) mumol/l and 480 (137-778) mumol/l, respectively. Acetic and propionic acid accounted for 85% and 11%, respectively, and i-butyric, n-butyric, and i-valeric for less than 2% each in jejunal aspirates. A very similar relative distribution was present also in saliva and gastric and duodenal aspirates, essentially different from that of feces. Through anaerobic culturing from jejunum, 10(3) to 10(8) bacteria/ml was obtained; there was no correlation between the log number of bacteria and the SCFAs concentration before and after ingestion of sucrose. Swallowed exogenous radiolabeled propionate was partly recovered in the jejunum. The findings indicate that the SCFAs recovered from the jejunum in healthy subjects are mainly produced in the mouth and swallowed with the saliva. |
| format | Article |
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Acetic and propionic acid accounted for 85% and 11%, respectively, and i-butyric, n-butyric, and i-valeric for less than 2% each in jejunal aspirates. A very similar relative distribution was present also in saliva and gastric and duodenal aspirates, essentially different from that of feces. Through anaerobic culturing from jejunum, 10(3) to 10(8) bacteria/ml was obtained; there was no correlation between the log number of bacteria and the SCFAs concentration before and after ingestion of sucrose. Swallowed exogenous radiolabeled propionate was partly recovered in the jejunum. The findings indicate that the SCFAs recovered from the jejunum in healthy subjects are mainly produced in the mouth and swallowed with the saliva.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>PMID: 6398506</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Scandinavian University Press</publisher><subject>Adult ; Bacteriological Techniques ; Biological and medical sciences ; Chromatography, Gas ; Duodenum ; Fatty Acids, Volatile - analysis ; Female ; Fundamental and applied biological sciences. 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Acetic and propionic acid accounted for 85% and 11%, respectively, and i-butyric, n-butyric, and i-valeric for less than 2% each in jejunal aspirates. A very similar relative distribution was present also in saliva and gastric and duodenal aspirates, essentially different from that of feces. Through anaerobic culturing from jejunum, 10(3) to 10(8) bacteria/ml was obtained; there was no correlation between the log number of bacteria and the SCFAs concentration before and after ingestion of sucrose. Swallowed exogenous radiolabeled propionate was partly recovered in the jejunum. The findings indicate that the SCFAs recovered from the jejunum in healthy subjects are mainly produced in the mouth and swallowed with the saliva.</description><subject>Adult</subject><subject>Bacteriological Techniques</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Gas</subject><subject>Duodenum</subject><subject>Fatty Acids, Volatile - analysis</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastric Juice - analysis</subject><subject>General aspects</subject><subject>Humans</subject><subject>Intestinal Secretions - analysis</subject><subject>Intestinal Secretions - microbiology</subject><subject>Jejunum</subject><subject>Male</subject><subject>Saliva - analysis</subject><subject>Vertebrates: digestive system</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kFtLxDAQhYMo67r6E4Q8iG-FXJomeRTxBguCl-cyTac2S7ddkxTcf2_A4tMwcz5mzpkTsuaKiUJrZk7JmjFZFUoJfk4uYtwxxpQu7YqsKmmNYtWavL33U0iF68GPtIOUjhScbyPNbeqRHsL04_cw0C-IKUx-TBiTH_MgBXCJTh3tEYbUH2mcmx26FC_JWQdDxKulbsjn48PH_XOxfX16ub_bFgchVT7JO6tQC5RNw4zQTkkNoFlb6qoExSU3Vamt48K0qjVacSw70yBaK5wAJzfk9m9v9vg9Z1v13keHwwAjTnOstbKci0pm8HoB52aPbX0IOVE41ssTsn6z6BAdDF2A0fn4j1khhFVG_gIs9GZ8</recordid><startdate>198411</startdate><enddate>198411</enddate><creator>HØVERSTAD, T</creator><creator>BJØRNEKLETT, A</creator><creator>MIDTVEDT, T</creator><creator>FAUSA, O</creator><creator>BØHMER, T</creator><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198411</creationdate><title>Short-chain fatty acids in the proximal gastrointestinal tract of healthy subjects</title><author>HØVERSTAD, T ; BJØRNEKLETT, A ; MIDTVEDT, T ; FAUSA, O ; BØHMER, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-c1f95e72e3bb0827c537aa70d4764a513186479c128d5d8751e4f8bee992c2ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Bacteriological Techniques</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Gas</topic><topic>Duodenum</topic><topic>Fatty Acids, Volatile - analysis</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastric Juice - analysis</topic><topic>General aspects</topic><topic>Humans</topic><topic>Intestinal Secretions - analysis</topic><topic>Intestinal Secretions - microbiology</topic><topic>Jejunum</topic><topic>Male</topic><topic>Saliva - analysis</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HØVERSTAD, T</creatorcontrib><creatorcontrib>BJØRNEKLETT, A</creatorcontrib><creatorcontrib>MIDTVEDT, T</creatorcontrib><creatorcontrib>FAUSA, O</creatorcontrib><creatorcontrib>BØHMER, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HØVERSTAD, T</au><au>BJØRNEKLETT, A</au><au>MIDTVEDT, T</au><au>FAUSA, O</au><au>BØHMER, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-chain fatty acids in the proximal gastrointestinal tract of healthy subjects</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1984-11</date><risdate>1984</risdate><volume>19</volume><issue>8</issue><spage>1053</spage><epage>1058</epage><pages>1053-1058</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>The total concentration of short-chain fatty acids (SCFAs) in healthy subjects, measured by gas chromatography, was in saliva and jejunal aspirates (n = 6) (median (range] 4480 (2780-9940) mumol/l and 265 (185-1470) mumol/l and in gastric and duodenal aspirates (n = 7) 719 (425-1770) mumol/l and 480 (137-778) mumol/l, respectively. Acetic and propionic acid accounted for 85% and 11%, respectively, and i-butyric, n-butyric, and i-valeric for less than 2% each in jejunal aspirates. A very similar relative distribution was present also in saliva and gastric and duodenal aspirates, essentially different from that of feces. Through anaerobic culturing from jejunum, 10(3) to 10(8) bacteria/ml was obtained; there was no correlation between the log number of bacteria and the SCFAs concentration before and after ingestion of sucrose. Swallowed exogenous radiolabeled propionate was partly recovered in the jejunum. The findings indicate that the SCFAs recovered from the jejunum in healthy subjects are mainly produced in the mouth and swallowed with the saliva.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Scandinavian University Press</pub><pmid>6398506</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Scandinavian journal of gastroenterology, 1984-11, Vol.19 (8), p.1053-1058 |
| issn | 0036-5521 1502-7708 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult Bacteriological Techniques Biological and medical sciences Chromatography, Gas Duodenum Fatty Acids, Volatile - analysis Female Fundamental and applied biological sciences. Psychology Gastric Juice - analysis General aspects Humans Intestinal Secretions - analysis Intestinal Secretions - microbiology Jejunum Male Saliva - analysis Vertebrates: digestive system |
| title | Short-chain fatty acids in the proximal gastrointestinal tract of healthy subjects |
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