Ischemic brain edema following occlusion of the middle cerebral artery in the rat. II: Alteration of the eicosanoid synthesis profile of brain microvessels
Using the rat middle cerebral artery occlusion model, alterations in the eicosanoid synthetic capacity of brain microvessels following ischemia were studied by radiochromatography. Brain microvessels of normal rats predominantly produced hydroxyacids with relatively small amounts of PGD2 and PGE2 fr...
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| Veröffentlicht in: | Stroke (1970) 1985, Vol.16 (1), p.110-113 |
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| container_title | Stroke (1970) |
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| creator | ASANO, T GOTOH, O KOIDE, T TAKAKURA, K |
| description | Using the rat middle cerebral artery occlusion model, alterations in the eicosanoid synthetic capacity of brain microvessels following ischemia were studied by radiochromatography. Brain microvessels of normal rats predominantly produced hydroxyacids with relatively small amounts of PGD2 and PGE2 from exogenous arachidonic acid. Confirmation that hydroxyacids and prostaglandins were products respectively of lipoxygenase(s) and cyclooxygenase was obtained by experiments using indomethacin and eicosatetraynoic acid. The eicosanoid synthetic capacity of the brain microvessel, especially of hydroxyacids, was significantly enhanced 24 and 72 hours after the onset of ischemia. Because this is the phase of maximum edema in the present model, enhanced eicosanoid production in the brain microvessel may be involved in the mechanisms that underly ischemic brain edema. |
| doi_str_mv | 10.1161/01.STR.16.1.110 |
| format | Article |
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The eicosanoid synthetic capacity of the brain microvessel, especially of hydroxyacids, was significantly enhanced 24 and 72 hours after the onset of ischemia. Because this is the phase of maximum edema in the present model, enhanced eicosanoid production in the brain microvessel may be involved in the mechanisms that underly ischemic brain edema.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.16.1.110</identifier><identifier>PMID: 3966253</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Arachidonic Acids - biosynthesis ; Biological and medical sciences ; Brain - blood supply ; Brain Ischemia - metabolism ; Cerebral Arteries - surgery ; Edema - metabolism ; Male ; Medical sciences ; Microcirculation - metabolism ; Nervous system involvement in other diseases. 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II: Alteration of the eicosanoid synthesis profile of brain microvessels</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Using the rat middle cerebral artery occlusion model, alterations in the eicosanoid synthetic capacity of brain microvessels following ischemia were studied by radiochromatography. Brain microvessels of normal rats predominantly produced hydroxyacids with relatively small amounts of PGD2 and PGE2 from exogenous arachidonic acid. Confirmation that hydroxyacids and prostaglandins were products respectively of lipoxygenase(s) and cyclooxygenase was obtained by experiments using indomethacin and eicosatetraynoic acid. The eicosanoid synthetic capacity of the brain microvessel, especially of hydroxyacids, was significantly enhanced 24 and 72 hours after the onset of ischemia. Because this is the phase of maximum edema in the present model, enhanced eicosanoid production in the brain microvessel may be involved in the mechanisms that underly ischemic brain edema.</description><subject>Animals</subject><subject>Arachidonic Acids - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Brain - blood supply</subject><subject>Brain Ischemia - metabolism</subject><subject>Cerebral Arteries - surgery</subject><subject>Edema - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microcirculation - metabolism</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Time Factors</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNUc1rFDEUD6LUtXr2JOQg3maar8lsvJWidqEgaD2HTPJiI5lJzZtV9m_xnzVll9LTg9_X-yWPkLec9ZxrfsF4__32W891zxvAnpENH4TqlBbb52TDmDSdUMa8JK8QfzHGhNwOZ-RMGq3FIDfk3w79HczJ06m6tFAIMDsaS87lb1p-0uJ93mMqCy2RrndA5xRCBuqhQnNk6uoK9UCb9YGtbu3pbveRXuYGu_WJEZIv6JaSAsXD0hBMSO9rianFNc1xf2tSyx9AhIyvyYvoMsKb0zwnPz5_ur267m6-ftldXd50XnLBOuWDVNJMkfsweh6Fc6CjGL127ekjKB2lDtroSUNQAxtHmOJ2nHRwShgzyXPy4Zjb2vzeA652TughZ7dA2aMdB8M0Z0MTXhyFrSNihWjva5pdPVjO7MM5LOO2ncNybXkDWHO8O0XvpxnCo_70_41_f-IdepdjdYtP-CgzghtmlPwPomSVfQ</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>ASANO, T</creator><creator>GOTOH, O</creator><creator>KOIDE, T</creator><creator>TAKAKURA, K</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>Ischemic brain edema following occlusion of the middle cerebral artery in the rat. II: Alteration of the eicosanoid synthesis profile of brain microvessels</title><author>ASANO, T ; GOTOH, O ; KOIDE, T ; TAKAKURA, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3120-4cd3439bf1cd7c1f2aae6f27c6a2497e46f36d696b6ed45077ebf87b6da4299b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Arachidonic Acids - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Brain - blood supply</topic><topic>Brain Ischemia - metabolism</topic><topic>Cerebral Arteries - surgery</topic><topic>Edema - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microcirculation - metabolism</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ASANO, T</creatorcontrib><creatorcontrib>GOTOH, O</creatorcontrib><creatorcontrib>KOIDE, T</creatorcontrib><creatorcontrib>TAKAKURA, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ASANO, T</au><au>GOTOH, O</au><au>KOIDE, T</au><au>TAKAKURA, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ischemic brain edema following occlusion of the middle cerebral artery in the rat. II: Alteration of the eicosanoid synthesis profile of brain microvessels</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>1985</date><risdate>1985</risdate><volume>16</volume><issue>1</issue><spage>110</spage><epage>113</epage><pages>110-113</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Using the rat middle cerebral artery occlusion model, alterations in the eicosanoid synthetic capacity of brain microvessels following ischemia were studied by radiochromatography. Brain microvessels of normal rats predominantly produced hydroxyacids with relatively small amounts of PGD2 and PGE2 from exogenous arachidonic acid. Confirmation that hydroxyacids and prostaglandins were products respectively of lipoxygenase(s) and cyclooxygenase was obtained by experiments using indomethacin and eicosatetraynoic acid. The eicosanoid synthetic capacity of the brain microvessel, especially of hydroxyacids, was significantly enhanced 24 and 72 hours after the onset of ischemia. Because this is the phase of maximum edema in the present model, enhanced eicosanoid production in the brain microvessel may be involved in the mechanisms that underly ischemic brain edema.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>3966253</pmid><doi>10.1161/01.STR.16.1.110</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Stroke (1970), 1985, Vol.16 (1), p.110-113 |
| issn | 0039-2499 1524-4628 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Animals Arachidonic Acids - biosynthesis Biological and medical sciences Brain - blood supply Brain Ischemia - metabolism Cerebral Arteries - surgery Edema - metabolism Male Medical sciences Microcirculation - metabolism Nervous system involvement in other diseases. Miscellaneous Neurology Rats Rats, Inbred Strains Time Factors |
| title | Ischemic brain edema following occlusion of the middle cerebral artery in the rat. II: Alteration of the eicosanoid synthesis profile of brain microvessels |
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