Retinoic acid induces insulin-like growth factor II expression in a neuroblastoma cell line
Insulin-like growth factor II (IGF-II) is implicated in the development of the vertebrate neural circuitry, and increases neurite growth in vitro and in vivo. We examined the relationship of IGF-II expression to the in vitro differentiation induced by retinoic acid (RA). We find that RA stimulates a...
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| Veröffentlicht in: | Cancer letters 1993-07, Vol.71 (1), p.177-182 |
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| container_title | Cancer letters |
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| creator | Ueno, Takaki Suita, Sachiyo Zaizen, Yoshio |
| description | Insulin-like growth factor II (IGF-II) is implicated in the development of the vertebrate neural circuitry, and increases neurite growth in vitro and in vivo. We examined the relationship of IGF-II expression to the in vitro differentiation induced by retinoic acid (RA). We find that RA stimulates an increase in IGF-II messenger RNA (mRNA) in the SK-N-SH (SH) neuroblastoma cell line. An increase of IGF-II mRNA is detected within 12 h of treatment and precedes morphological differentiation. A RA dose response test indicates that an increase in IGF-II mRNA occurs within 2 days in SH cells treated with doses of RA from 1 × 10
−8 to 1 × 10
−5 M. We suggest that IGF-II expression may be regulated either directly or indirectly by RA in vitro and may lead to neuroblastoma differentiation. |
| doi_str_mv | 10.1016/0304-3835(93)90113-N |
| format | Article |
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−8 to 1 × 10
−5 M. We suggest that IGF-II expression may be regulated either directly or indirectly by RA in vitro and may lead to neuroblastoma differentiation.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/0304-3835(93)90113-N</identifier><identifier>PMID: 8364891</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Antineoplastic agents ; Biological and medical sciences ; Cell Differentiation ; Cell Line - drug effects ; Cell Line - metabolism ; Chemotherapy ; differentiation ; Dose-Response Relationship, Drug ; Gene Expression Regulation - drug effects ; Humans ; insulin-like growth factor II ; Insulin-Like Growth Factor II - genetics ; Insulin-Like Growth Factor II - metabolism ; Medical sciences ; Neurites - drug effects ; neuroblastoma ; Neuroblastoma - drug therapy ; Pharmacology. Drug treatments ; retinoic acid ; RNA, Messenger - analysis ; Time Factors ; Tretinoin - pharmacology</subject><ispartof>Cancer letters, 1993-07, Vol.71 (1), p.177-182</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-a874f31036fe231140068cf71225930b320542d469419362054381c7324cb9b33</citedby><cites>FETCH-LOGICAL-c386t-a874f31036fe231140068cf71225930b320542d469419362054381c7324cb9b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/030438359390113N$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4905553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8364891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ueno, Takaki</creatorcontrib><creatorcontrib>Suita, Sachiyo</creatorcontrib><creatorcontrib>Zaizen, Yoshio</creatorcontrib><title>Retinoic acid induces insulin-like growth factor II expression in a neuroblastoma cell line</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Insulin-like growth factor II (IGF-II) is implicated in the development of the vertebrate neural circuitry, and increases neurite growth in vitro and in vivo. We examined the relationship of IGF-II expression to the in vitro differentiation induced by retinoic acid (RA). We find that RA stimulates an increase in IGF-II messenger RNA (mRNA) in the SK-N-SH (SH) neuroblastoma cell line. An increase of IGF-II mRNA is detected within 12 h of treatment and precedes morphological differentiation. A RA dose response test indicates that an increase in IGF-II mRNA occurs within 2 days in SH cells treated with doses of RA from 1 × 10
−8 to 1 × 10
−5 M. We suggest that IGF-II expression may be regulated either directly or indirectly by RA in vitro and may lead to neuroblastoma differentiation.</description><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation</subject><subject>Cell Line - drug effects</subject><subject>Cell Line - metabolism</subject><subject>Chemotherapy</subject><subject>differentiation</subject><subject>Dose-Response Relationship, Drug</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Humans</subject><subject>insulin-like growth factor II</subject><subject>Insulin-Like Growth Factor II - genetics</subject><subject>Insulin-Like Growth Factor II - metabolism</subject><subject>Medical sciences</subject><subject>Neurites - drug effects</subject><subject>neuroblastoma</subject><subject>Neuroblastoma - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>retinoic acid</subject><subject>RNA, Messenger - analysis</subject><subject>Time Factors</subject><subject>Tretinoin - pharmacology</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVp2Gw-_kEDOpSQHpxIHtmWLoWwpM3CsoWQnHIQsjxulXitrWSnyb-P3TV7zGkQ87yjl4eQL5xdcsbzKwZMJCAhu1DwTTHOIVl_InMuizQplGSfyXyPHJKjGJ8YY5koshmZSciFVHxOHu-wc613lhrrKuraqrcYhxn7xrVJ456R_g7-X_eH1sZ2PtDlkuLrNmCMzrcDSA1tsQ--bEzs_MZQi01DhzCekIPaNBFPp3lMHn7c3C9uk9Wvn8vF9SqxIPMuMbIQNXAGeY0pcC4Yy6WtC56mmQJWQjq0TiuRK8EV5OMLJLcFpMKWqgQ4Jue7u9vg__YYO71xcWxhWvR91EU22FFiBMUOtMHHGLDW2-A2JrxpzvToVI_C9ChMK9D_ner1EDub7vflBqt9aJI47L9OexOtaepgWuviHhOKZVk2_v59h-Hg4sVh0NE6bC1WLqDtdOXdxz3eAVbBkKc</recordid><startdate>19930730</startdate><enddate>19930730</enddate><creator>Ueno, Takaki</creator><creator>Suita, Sachiyo</creator><creator>Zaizen, Yoshio</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930730</creationdate><title>Retinoic acid induces insulin-like growth factor II expression in a neuroblastoma cell line</title><author>Ueno, Takaki ; Suita, Sachiyo ; Zaizen, Yoshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-a874f31036fe231140068cf71225930b320542d469419362054381c7324cb9b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation</topic><topic>Cell Line - drug effects</topic><topic>Cell Line - metabolism</topic><topic>Chemotherapy</topic><topic>differentiation</topic><topic>Dose-Response Relationship, Drug</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Humans</topic><topic>insulin-like growth factor II</topic><topic>Insulin-Like Growth Factor II - genetics</topic><topic>Insulin-Like Growth Factor II - metabolism</topic><topic>Medical sciences</topic><topic>Neurites - drug effects</topic><topic>neuroblastoma</topic><topic>Neuroblastoma - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>retinoic acid</topic><topic>RNA, Messenger - analysis</topic><topic>Time Factors</topic><topic>Tretinoin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ueno, Takaki</creatorcontrib><creatorcontrib>Suita, Sachiyo</creatorcontrib><creatorcontrib>Zaizen, Yoshio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ueno, Takaki</au><au>Suita, Sachiyo</au><au>Zaizen, Yoshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinoic acid induces insulin-like growth factor II expression in a neuroblastoma cell line</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1993-07-30</date><risdate>1993</risdate><volume>71</volume><issue>1</issue><spage>177</spage><epage>182</epage><pages>177-182</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>Insulin-like growth factor II (IGF-II) is implicated in the development of the vertebrate neural circuitry, and increases neurite growth in vitro and in vivo. We examined the relationship of IGF-II expression to the in vitro differentiation induced by retinoic acid (RA). We find that RA stimulates an increase in IGF-II messenger RNA (mRNA) in the SK-N-SH (SH) neuroblastoma cell line. An increase of IGF-II mRNA is detected within 12 h of treatment and precedes morphological differentiation. A RA dose response test indicates that an increase in IGF-II mRNA occurs within 2 days in SH cells treated with doses of RA from 1 × 10
−8 to 1 × 10
−5 M. We suggest that IGF-II expression may be regulated either directly or indirectly by RA in vitro and may lead to neuroblastoma differentiation.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8364891</pmid><doi>10.1016/0304-3835(93)90113-N</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1993-07, Vol.71 (1), p.177-182 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antineoplastic agents Biological and medical sciences Cell Differentiation Cell Line - drug effects Cell Line - metabolism Chemotherapy differentiation Dose-Response Relationship, Drug Gene Expression Regulation - drug effects Humans insulin-like growth factor II Insulin-Like Growth Factor II - genetics Insulin-Like Growth Factor II - metabolism Medical sciences Neurites - drug effects neuroblastoma Neuroblastoma - drug therapy Pharmacology. Drug treatments retinoic acid RNA, Messenger - analysis Time Factors Tretinoin - pharmacology |
| title | Retinoic acid induces insulin-like growth factor II expression in a neuroblastoma cell line |
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