Recombinant α-interferon 2b in the treatment of HIV-related thrombocytopenia

To assess the efficacy and the mechanism of action of alpha-interferon (alpha-IFN) in the treatment of HIV-related thrombocytopenia. Thirteen HIV-positive subjects [nine men and four women with severe thrombocytopenia (platelets, < or = 30 x 10(9)/l)] were treated with alpha-IFN 2b alone at a dos...

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Veröffentlicht in:	AIDS (London) 1993-06, Vol.7 (6), p.823-827
Hauptverfasser:	VIANELLI, N, CATANI, L, BAGNARA, G. P, TURA, S, GUGLIOTTA, L, BELMONTE, M. M, CASCIONE, L, COLANGELI, V, RICCHI, E, MAZZA, P, MAZZUCCONI, M. G, CHISTOLINI, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS-Related Complex - blood AIDS-Related Complex - complications AIDS/HIV Autoimmune Diseases - blood Autoimmune Diseases - complications Autoimmune Diseases - therapy Biological and medical sciences Cell Survival Cells, Cultured Colony-Forming Units Assay Drug Evaluation Erythroid Precursor Cells - drug effects Erythroid Precursor Cells - pathology Erythropoietin - pharmacology Female Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Hematopoiesis - drug effects human immunodeficiency virus Humans Immunomodulators Interferon alpha-2 Interferon-alpha - therapeutic use Interleukin-3 - pharmacology Male Medical sciences Megakaryocytes - drug effects Megakaryocytes - pathology Pharmacology. Drug treatments Platelet Count - drug effects Purpura, Thrombocytopenic, Idiopathic - blood Purpura, Thrombocytopenic, Idiopathic - complications Purpura, Thrombocytopenic, Idiopathic - therapy Recombinant Proteins - pharmacology Thrombocytopenia - blood Thrombocytopenia - complications Thrombocytopenia - pathology Thrombocytopenia - therapy
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