Drastic reduction of the zinc- and magnesium-stimulated protein tyrosine kinase activities in Alzheimer's disease hippocampus

Tyrosine phosphorylation of proteins from postmortem hippocampi of five Alzheimer's disease and five control cases have been compared. It was found that addition of Zn 2+ or Mg 2+ to membrane fractions of control hippocampi caused the phosphorylation of 32-, 40-, 55-, 60-, 80- and 100-kDa prote...

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Veröffentlicht in:	FEBS letters 1993-08, Vol.328 (1), p.6-8
Hauptverfasser:	Vener, Alexander V., Aksenova, Marina V., Burbaeva, Gulnur Sh
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Alzheimer's disease Blotting, Western Cell Membrane - drug effects Cell Membrane - enzymology Electrophoresis, Polyacrylamide Gel Female Hippocampus - drug effects Hippocampus - enzymology Human hippocampus Humans Magnesium Magnesium - pharmacology Male Middle Aged Molecular Weight Phosphorylation Phosphotyrosine Protein phosphorylation Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins pp60(c-src) - metabolism Tyrosine - analogs & derivatives Tyrosine - metabolism Zinc Zinc - pharmacology
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