Localization of the Potassium Ion Activation Site in Human Liver Fructose 1,6-Bisphosphatase

Three mouse monoclonal antibodies of human liver fructose 1,6-bisphosphatase are shown to bind to the enzyme at different sites as determined by ELISA. The binding of one of the monoclonal antibodies, L2E1, mimics the effects of K + ions, including increase in the enzyme activity and enhancement of...

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Veröffentlicht in:	Biochemical and biophysical research communications 1993-08, Vol.194 (3), p.1483-1490
Hauptverfasser:	Xu, G.J., Yu, Z.B., Hu, G.F., Cao, H.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Antibodies, Monoclonal - metabolism Biological and medical sciences Enzyme Activation - drug effects Enzymes and enzyme inhibitors Fructose-Bisphosphatase - metabolism Fundamental and applied biological sciences. Psychology Humans Hydrolases Liver - enzymology Peptide Fragments - metabolism Potassium - metabolism Structure-Activity Relationship
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