Site-specific methylation inhibits transcriptional activity of platelet-derived growth factor A-chain promoter

Expression of the platelet-derived growth factor (PDGF) A-chain gene is temporally and spatially restricted in development and highly regulated in selected normal and tumor cell lines. Because DNA methylation appears to be important in regulating tissue specific gene expression, we tested the influe...

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Veröffentlicht in:	The Journal of biological chemistry 1993-08, Vol.268 (23), p.17334-17340
Hauptverfasser:	XIN-HUA LIN, CHAN GUO, LI JUAN GU, DEUEL, T. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Base Sequence Biological and medical sciences Cloning, Molecular DNA - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation HeLa Cells Humans Methylation Molecular Sequence Data Platelet-Derived Growth Factor - genetics Promoter Regions, Genetic Protein hormones. Growth factors. Cytokines Proteins Restriction Mapping Transcription, Genetic Transfection Tumor Cells, Cultured
Online-Zugang:	Volltext
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