ENHANCEMENT OF LYMPHATIC TRANSPORT OF N1-(2-TETRAHYDROFURYL)-5-FLUOROURACIL (FT-207) BY WATER-IN-OIL EMULSION IN POSTOPERATIVE ADJUVANT CHEMOTHERAPY FOR GASTRIC CANCER

In 7 postoperative gastric cancer patients, the influence of fat emulsification of N1 (2-tetrahydrofuryl)-5-fluorouracil (FT-207) on lymphatic transport was investigated. The water in oil type of emulsion of FT-207 (FT-w/o) and enteric coated preparation (FT-G) in 1 gram each calculated in terms of FT-207 were administered orally, and lymph from the thoracic duct fistula prepared in advance and blood from peripheral vein were collected simultaneously with time after the administration to determine the concentrations of FT-207 and 5-fluorouracil. In FT-w/o, FT-207 concentration showed significantly higher values than those in FT-G in 30-120 minutes after the administration, respectively, both in lymph and blood. In FT-w/o, 5-FU concentration showed a significantly higher value than that in FT-G in lymph 30-240 minutes and in blood 30-480 minutes after the administration. Thus, FT-w/o having the excellent activity in lymph and blood transition was considered useful as a adjuvant chemotherapeutic drug for postoperative treatment in gastric cancer.