Plasma brain natriuretic peptide and atrial natriuretic peptide concentrations correlate with left ventricular end‐diastolic pressure
The present study was designed to investigate whether brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) plasma concentrations correlate with left ventricular end‐diastolic pressure (LVEDP), pulmonary capillary wedge pressure (PCWP), diastolic pulmonary arterial pressure (DPAP), ri...
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| Veröffentlicht in: | Clinical cardiology (Mahwah, N.J.) N.J.), 1993-07, Vol.16 (7), p.553-557 |
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| creator | Haug, C. Grünert, A. Metzele, A. Kochs, M. Hombach, V. |
| description | The present study was designed to investigate whether brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) plasma concentrations correlate with left ventricular end‐diastolic pressure (LVEDP), pulmonary capillary wedge pressure (PCWP), diastolic pulmonary arterial pressure (DPAP), right atrial pressure (RAP), or ejection fraction (EF). Plasma BNP and ANP levels were determined by commercial radioimmunoassays (Peninsula) after Sep Pak C18 extraction in blood samples withdrawn from the pulmonary artery and the left ventricle or from the left ventricle and the femoral vein in 85 patients undergoing diagnostic cardiac catheterization. Linear and nonlinear regression analysis and the paired sample f‐test were applied to the data. Pulmonary arterial plasma BNP and ANP levels showed a close nonlinear correlation with LVEDP (BNP: r=0.94, p < 0.001; ANP: r=0.81, p < 0.001), a significant linear correlation with PCWP, DPAP, and RAP, and a significant negative correlation with EE ANP concentrations decreased significantly from the pulmonary artery to the left ventricle and from the left ventricle to the femoral vein (p < 0.001). BNP levels also decreased significantly between the left ventricle and the femoral vein (p < 0.001), but there was no significant difference between pulmonary arterial and left ventricular BNP concentrations. BNP and ANP concentrations correlated significantly between pulmonary arterial and left ventricular blood samples (BNP: r = 0.99, ANP: r = 0.93, p < 0.001) and between left ventricular and peripheral blood samples (BNP: r=0.99, ANP: r=0.94, p |
| doi_str_mv | 10.1002/clc.4960160708 |
| format | Article |
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Plasma BNP and ANP levels were determined by commercial radioimmunoassays (Peninsula) after Sep Pak C18 extraction in blood samples withdrawn from the pulmonary artery and the left ventricle or from the left ventricle and the femoral vein in 85 patients undergoing diagnostic cardiac catheterization. Linear and nonlinear regression analysis and the paired sample f‐test were applied to the data. Pulmonary arterial plasma BNP and ANP levels showed a close nonlinear correlation with LVEDP (BNP: r=0.94, p < 0.001; ANP: r=0.81, p < 0.001), a significant linear correlation with PCWP, DPAP, and RAP, and a significant negative correlation with EE ANP concentrations decreased significantly from the pulmonary artery to the left ventricle and from the left ventricle to the femoral vein (p < 0.001). BNP levels also decreased significantly between the left ventricle and the femoral vein (p < 0.001), but there was no significant difference between pulmonary arterial and left ventricular BNP concentrations. BNP and ANP concentrations correlated significantly between pulmonary arterial and left ventricular blood samples (BNP: r = 0.99, ANP: r = 0.93, p < 0.001) and between left ventricular and peripheral blood samples (BNP: r=0.99, ANP: r=0.94, p<0.001). The present data suggest that peripheral plasma BNP and ANP levels are useful noninvasive indices of cardiac performance.]]></description><identifier>ISSN: 0160-9289</identifier><identifier>EISSN: 1932-8737</identifier><identifier>DOI: 10.1002/clc.4960160708</identifier><identifier>PMID: 8348764</identifier><identifier>CODEN: CLCADC</identifier><language>eng</language><publisher>New York: Wiley Periodicals, Inc</publisher><subject>Atrial Function, Right - physiology ; Atrial Natriuretic Factor - blood ; atrial natriuretic peptide ; Biological and medical sciences ; brain natriuretic peptide ; Cardiac Catheterization ; Cardiology. Vascular system ; Cardiopathies: etiologic forms (general aspects and miscellaneous) ; Coronary Disease - blood ; Coronary Disease - diagnosis ; diastolic pulmonary arterial pressure ; ejection fraction ; Female ; Heart ; Humans ; left ventricular end‐diastolic pressure ; Male ; Medical sciences ; Middle Aged ; Natriuretic Peptide, Brain ; Nerve Tissue Proteins - blood ; pulmonary capillary wedge pressure ; Pulmonary Wedge Pressure - physiology ; Radioimmunoassay ; Regression Analysis ; right atrial pressure ; Stroke Volume - physiology ; Ventricular Function, Left - physiology</subject><ispartof>Clinical cardiology (Mahwah, N.J.), 1993-07, Vol.16 (7), p.553-557</ispartof><rights>Copyright © 1993 Wiley Periodicals, Inc.</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4098-41d86fb2dda58a64b853a38b951df8b81c8484e39e8a44a832017449714717453</citedby><cites>FETCH-LOGICAL-c4098-41d86fb2dda58a64b853a38b951df8b81c8484e39e8a44a832017449714717453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fclc.4960160708$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fclc.4960160708$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27913,27914,45563,45564</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4797261$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8348764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haug, C.</creatorcontrib><creatorcontrib>Grünert, A.</creatorcontrib><creatorcontrib>Metzele, A.</creatorcontrib><creatorcontrib>Kochs, M.</creatorcontrib><creatorcontrib>Hombach, V.</creatorcontrib><title>Plasma brain natriuretic peptide and atrial natriuretic peptide concentrations correlate with left ventricular end‐diastolic pressure</title><title>Clinical cardiology (Mahwah, N.J.)</title><addtitle>Clin Cardiol</addtitle><description><![CDATA[The present study was designed to investigate whether brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) plasma concentrations correlate with left ventricular end‐diastolic pressure (LVEDP), pulmonary capillary wedge pressure (PCWP), diastolic pulmonary arterial pressure (DPAP), right atrial pressure (RAP), or ejection fraction (EF). Plasma BNP and ANP levels were determined by commercial radioimmunoassays (Peninsula) after Sep Pak C18 extraction in blood samples withdrawn from the pulmonary artery and the left ventricle or from the left ventricle and the femoral vein in 85 patients undergoing diagnostic cardiac catheterization. Linear and nonlinear regression analysis and the paired sample f‐test were applied to the data. Pulmonary arterial plasma BNP and ANP levels showed a close nonlinear correlation with LVEDP (BNP: r=0.94, p < 0.001; ANP: r=0.81, p < 0.001), a significant linear correlation with PCWP, DPAP, and RAP, and a significant negative correlation with EE ANP concentrations decreased significantly from the pulmonary artery to the left ventricle and from the left ventricle to the femoral vein (p < 0.001). BNP levels also decreased significantly between the left ventricle and the femoral vein (p < 0.001), but there was no significant difference between pulmonary arterial and left ventricular BNP concentrations. BNP and ANP concentrations correlated significantly between pulmonary arterial and left ventricular blood samples (BNP: r = 0.99, ANP: r = 0.93, p < 0.001) and between left ventricular and peripheral blood samples (BNP: r=0.99, ANP: r=0.94, p<0.001). The present data suggest that peripheral plasma BNP and ANP levels are useful noninvasive indices of cardiac performance.]]></description><subject>Atrial Function, Right - physiology</subject><subject>Atrial Natriuretic Factor - blood</subject><subject>atrial natriuretic peptide</subject><subject>Biological and medical sciences</subject><subject>brain natriuretic peptide</subject><subject>Cardiac Catheterization</subject><subject>Cardiology. Vascular system</subject><subject>Cardiopathies: etiologic forms (general aspects and miscellaneous)</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - diagnosis</subject><subject>diastolic pulmonary arterial pressure</subject><subject>ejection fraction</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>left ventricular end‐diastolic pressure</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain</subject><subject>Nerve Tissue Proteins - blood</subject><subject>pulmonary capillary wedge pressure</subject><subject>Pulmonary Wedge Pressure - physiology</subject><subject>Radioimmunoassay</subject><subject>Regression Analysis</subject><subject>right atrial pressure</subject><subject>Stroke Volume - physiology</subject><subject>Ventricular Function, Left - physiology</subject><issn>0160-9289</issn><issn>1932-8737</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDGP1DAQhS0EOvYOWjqkFIguix078bhEK-CQVoIC6mhiT4SR11lsh9N1dLT8Rn4JCbs6KJCoPJ73zZvRY-yJ4FvBefPCBrtVpuOi45rDPbYRRjY1aKnvs83arU0D5iG7zPnzwnNo5AW7AKlAd2rDvr8PmA9YDQl9rCKW5OdExdvqSMfiHVUYXbW2MfxTtlO0FEvC4qeYl29KFLBQdePLpyrQWKqvq-7tHDBVFN3Pbz-cx1ymsNokynmxfMQejBgyPT6_V-zj61cfdtf1_t2bt7uX-9oqbqBWwkE3Do1z2AJ2aoBWooTBtMKNMICwoECRNASoFIJsuNBKGS2UXopWXrHnJ99jmr7MlEt_8NlSCBhpmnOvWzBCdmIBtyfQpinnRGN_TP6A6bYXvF-T75fk-z_JLwNPz87zcCB3h5-jXvRnZx2zxTAmjNbnO0xpo5vfe80Ju_GBbv-ztN_td3-d8AvaV6AF</recordid><startdate>199307</startdate><enddate>199307</enddate><creator>Haug, C.</creator><creator>Grünert, A.</creator><creator>Metzele, A.</creator><creator>Kochs, M.</creator><creator>Hombach, V.</creator><general>Wiley Periodicals, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199307</creationdate><title>Plasma brain natriuretic peptide and atrial natriuretic peptide concentrations correlate with left ventricular end‐diastolic pressure</title><author>Haug, C. ; Grünert, A. ; Metzele, A. ; Kochs, M. ; Hombach, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4098-41d86fb2dda58a64b853a38b951df8b81c8484e39e8a44a832017449714717453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Atrial Function, Right - physiology</topic><topic>Atrial Natriuretic Factor - blood</topic><topic>atrial natriuretic peptide</topic><topic>Biological and medical sciences</topic><topic>brain natriuretic peptide</topic><topic>Cardiac Catheterization</topic><topic>Cardiology. Vascular system</topic><topic>Cardiopathies: etiologic forms (general aspects and miscellaneous)</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - diagnosis</topic><topic>diastolic pulmonary arterial pressure</topic><topic>ejection fraction</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>left ventricular end‐diastolic pressure</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain</topic><topic>Nerve Tissue Proteins - blood</topic><topic>pulmonary capillary wedge pressure</topic><topic>Pulmonary Wedge Pressure - physiology</topic><topic>Radioimmunoassay</topic><topic>Regression Analysis</topic><topic>right atrial pressure</topic><topic>Stroke Volume - physiology</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haug, C.</creatorcontrib><creatorcontrib>Grünert, A.</creatorcontrib><creatorcontrib>Metzele, A.</creatorcontrib><creatorcontrib>Kochs, M.</creatorcontrib><creatorcontrib>Hombach, V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haug, C.</au><au>Grünert, A.</au><au>Metzele, A.</au><au>Kochs, M.</au><au>Hombach, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma brain natriuretic peptide and atrial natriuretic peptide concentrations correlate with left ventricular end‐diastolic pressure</atitle><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle><addtitle>Clin Cardiol</addtitle><date>1993-07</date><risdate>1993</risdate><volume>16</volume><issue>7</issue><spage>553</spage><epage>557</epage><pages>553-557</pages><issn>0160-9289</issn><eissn>1932-8737</eissn><coden>CLCADC</coden><abstract><![CDATA[The present study was designed to investigate whether brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) plasma concentrations correlate with left ventricular end‐diastolic pressure (LVEDP), pulmonary capillary wedge pressure (PCWP), diastolic pulmonary arterial pressure (DPAP), right atrial pressure (RAP), or ejection fraction (EF). Plasma BNP and ANP levels were determined by commercial radioimmunoassays (Peninsula) after Sep Pak C18 extraction in blood samples withdrawn from the pulmonary artery and the left ventricle or from the left ventricle and the femoral vein in 85 patients undergoing diagnostic cardiac catheterization. Linear and nonlinear regression analysis and the paired sample f‐test were applied to the data. Pulmonary arterial plasma BNP and ANP levels showed a close nonlinear correlation with LVEDP (BNP: r=0.94, p < 0.001; ANP: r=0.81, p < 0.001), a significant linear correlation with PCWP, DPAP, and RAP, and a significant negative correlation with EE ANP concentrations decreased significantly from the pulmonary artery to the left ventricle and from the left ventricle to the femoral vein (p < 0.001). BNP levels also decreased significantly between the left ventricle and the femoral vein (p < 0.001), but there was no significant difference between pulmonary arterial and left ventricular BNP concentrations. BNP and ANP concentrations correlated significantly between pulmonary arterial and left ventricular blood samples (BNP: r = 0.99, ANP: r = 0.93, p < 0.001) and between left ventricular and peripheral blood samples (BNP: r=0.99, ANP: r=0.94, p<0.001). The present data suggest that peripheral plasma BNP and ANP levels are useful noninvasive indices of cardiac performance.]]></abstract><cop>New York</cop><pub>Wiley Periodicals, Inc</pub><pmid>8348764</pmid><doi>10.1002/clc.4960160708</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical cardiology (Mahwah, N.J.), 1993-07, Vol.16 (7), p.553-557 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Atrial Function, Right - physiology Atrial Natriuretic Factor - blood atrial natriuretic peptide Biological and medical sciences brain natriuretic peptide Cardiac Catheterization Cardiology. Vascular system Cardiopathies: etiologic forms (general aspects and miscellaneous) Coronary Disease - blood Coronary Disease - diagnosis diastolic pulmonary arterial pressure ejection fraction Female Heart Humans left ventricular end‐diastolic pressure Male Medical sciences Middle Aged Natriuretic Peptide, Brain Nerve Tissue Proteins - blood pulmonary capillary wedge pressure Pulmonary Wedge Pressure - physiology Radioimmunoassay Regression Analysis right atrial pressure Stroke Volume - physiology Ventricular Function, Left - physiology |
| title | Plasma brain natriuretic peptide and atrial natriuretic peptide concentrations correlate with left ventricular end‐diastolic pressure |
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