Phallic Growth After hCG: A Clinical Index of Androgen Responsiveness
Clinical and hormonal responses to a standard three-day human chorionic gonadotropin (hCG)-stimulation test (1,500 IU given intramuscularly for three days) were studied in six neonates with ambiguous genitalia. All patients were eventually determined to be 46,XY genetic males with a microphallus and...
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| Veröffentlicht in: | Clinical pediatrics 1993-06, Vol.32 (6), p.329-333 |
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| creator | Almaguer, Manuela C. Saenger, Paul Linder, Barbara L. |
| description | Clinical and hormonal responses to a standard three-day human chorionic gonadotropin (hCG)-stimulation test (1,500 IU given intramuscularly for three days) were studied in six neonates with ambiguous genitalia. All patients were eventually determined to be 46,XY genetic males with a microphallus and various other genital abnormalities. None had an enzymatic defect in steroidogenesis or a 5α-reductase deficiency, as determined by standard adrenocorticotropic hormone (ACTH) and hCG testing. All patients demonstrated penile growth (0.25 to 0.75 cm) within five days of hCG administration, with four of six patients achieving a normal penile length (>2.0 cm) by 48 hours after the last of three daily hCG injections. Androgen responsiveness suggested by phallic growth may help support a male sex assignment in such infants. |
| doi_str_mv | 10.1177/000992289303200602 |
| format | Article |
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All patients were eventually determined to be 46,XY genetic males with a microphallus and various other genital abnormalities. None had an enzymatic defect in steroidogenesis or a 5α-reductase deficiency, as determined by standard adrenocorticotropic hormone (ACTH) and hCG testing. All patients demonstrated penile growth (0.25 to 0.75 cm) within five days of hCG administration, with four of six patients achieving a normal penile length (>2.0 cm) by 48 hours after the last of three daily hCG injections. Androgen responsiveness suggested by phallic growth may help support a male sex assignment in such infants.</description><identifier>ISSN: 0009-9228</identifier><identifier>EISSN: 1938-2707</identifier><identifier>DOI: 10.1177/000992289303200602</identifier><identifier>PMID: 8393754</identifier><identifier>CODEN: CPEDAM</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Adrenocorticotropic Hormone ; Androgens - blood ; Biological and medical sciences ; Genital system. Reproduction ; Gonadal Dysgenesis, 46,XY - blood ; Gonadal Dysgenesis, 46,XY - diagnosis ; Gonadal Dysgenesis, 46,XY - drug therapy ; Gonadal Dysgenesis, 46,XY - genetics ; Growth Hormone - administration & dosage ; Growth Hormone - therapeutic use ; Humans ; Infant, Newborn ; Injections, Intramuscular ; Karyotyping ; Male ; Medical sciences ; Penis - abnormalities ; Penis - drug effects ; Penis - growth & development ; Pharmacology. 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All patients were eventually determined to be 46,XY genetic males with a microphallus and various other genital abnormalities. None had an enzymatic defect in steroidogenesis or a 5α-reductase deficiency, as determined by standard adrenocorticotropic hormone (ACTH) and hCG testing. All patients demonstrated penile growth (0.25 to 0.75 cm) within five days of hCG administration, with four of six patients achieving a normal penile length (>2.0 cm) by 48 hours after the last of three daily hCG injections. Androgen responsiveness suggested by phallic growth may help support a male sex assignment in such infants.</description><subject>Adrenocorticotropic Hormone</subject><subject>Androgens - blood</subject><subject>Biological and medical sciences</subject><subject>Genital system. Reproduction</subject><subject>Gonadal Dysgenesis, 46,XY - blood</subject><subject>Gonadal Dysgenesis, 46,XY - diagnosis</subject><subject>Gonadal Dysgenesis, 46,XY - drug therapy</subject><subject>Gonadal Dysgenesis, 46,XY - genetics</subject><subject>Growth Hormone - administration & dosage</subject><subject>Growth Hormone - therapeutic use</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Injections, Intramuscular</subject><subject>Karyotyping</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Penis - abnormalities</subject><subject>Penis - drug effects</subject><subject>Penis - growth & development</subject><subject>Pharmacology. Drug treatments</subject><issn>0009-9228</issn><issn>1938-2707</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFLwzAUxoMoc07vIgg7iLe695K0SY5j6BQGetBzSNPEdXTrTFrE_96WlV0ET-_w_b7vvfcRcoPwgCjEDACUolQqBowCZEBPyBgVkwkVIE7JuAeSnjgnFzFuAJBBykZkJJliIuVjcv22NlVV2uky1N_Nejr3jQvT9WJ5Sc68qaK7GuaEfDw9vi-ek9Xr8mUxXyWWoWwSb8Fn4PPcSCW49JIjQ6pAUE4LX3DbncbQpM5lWIDn1Gfc5h5zTCW1BtiE3B9y96H-al1s9LaM1lWV2bm6jVqkUkH_4oTQA2hDHWNwXu9DuTXhRyPovg79t47OdDukt_nWFUfL8H-n3w26idZUPpidLeMR41JgxnpsdsCi-XR6U7dh13Xy3-JfVvdxBw</recordid><startdate>19930601</startdate><enddate>19930601</enddate><creator>Almaguer, Manuela C.</creator><creator>Saenger, Paul</creator><creator>Linder, Barbara L.</creator><general>SAGE Publications</general><general>Westminster</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930601</creationdate><title>Phallic Growth After hCG</title><author>Almaguer, Manuela C. ; Saenger, Paul ; Linder, Barbara L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-fc0f60fbba89748f841312907242dfd4c30331a5ee61d0f42f64cbf1b1582ca03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adrenocorticotropic Hormone</topic><topic>Androgens - blood</topic><topic>Biological and medical sciences</topic><topic>Genital system. Reproduction</topic><topic>Gonadal Dysgenesis, 46,XY - blood</topic><topic>Gonadal Dysgenesis, 46,XY - diagnosis</topic><topic>Gonadal Dysgenesis, 46,XY - drug therapy</topic><topic>Gonadal Dysgenesis, 46,XY - genetics</topic><topic>Growth Hormone - administration & dosage</topic><topic>Growth Hormone - therapeutic use</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Injections, Intramuscular</topic><topic>Karyotyping</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Penis - abnormalities</topic><topic>Penis - drug effects</topic><topic>Penis - growth & development</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Almaguer, Manuela C.</creatorcontrib><creatorcontrib>Saenger, Paul</creatorcontrib><creatorcontrib>Linder, Barbara L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Almaguer, Manuela C.</au><au>Saenger, Paul</au><au>Linder, Barbara L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phallic Growth After hCG: A Clinical Index of Androgen Responsiveness</atitle><jtitle>Clinical pediatrics</jtitle><addtitle>Clin Pediatr (Phila)</addtitle><date>1993-06-01</date><risdate>1993</risdate><volume>32</volume><issue>6</issue><spage>329</spage><epage>333</epage><pages>329-333</pages><issn>0009-9228</issn><eissn>1938-2707</eissn><coden>CPEDAM</coden><abstract>Clinical and hormonal responses to a standard three-day human chorionic gonadotropin (hCG)-stimulation test (1,500 IU given intramuscularly for three days) were studied in six neonates with ambiguous genitalia. All patients were eventually determined to be 46,XY genetic males with a microphallus and various other genital abnormalities. None had an enzymatic defect in steroidogenesis or a 5α-reductase deficiency, as determined by standard adrenocorticotropic hormone (ACTH) and hCG testing. All patients demonstrated penile growth (0.25 to 0.75 cm) within five days of hCG administration, with four of six patients achieving a normal penile length (>2.0 cm) by 48 hours after the last of three daily hCG injections. Androgen responsiveness suggested by phallic growth may help support a male sex assignment in such infants.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>8393754</pmid><doi>10.1177/000992289303200602</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9228 |
| ispartof | Clinical pediatrics, 1993-06, Vol.32 (6), p.329-333 |
| issn | 0009-9228 1938-2707 |
| language | eng |
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| source | MEDLINE; SAGE Complete |
| subjects | Adrenocorticotropic Hormone Androgens - blood Biological and medical sciences Genital system. Reproduction Gonadal Dysgenesis, 46,XY - blood Gonadal Dysgenesis, 46,XY - diagnosis Gonadal Dysgenesis, 46,XY - drug therapy Gonadal Dysgenesis, 46,XY - genetics Growth Hormone - administration & dosage Growth Hormone - therapeutic use Humans Infant, Newborn Injections, Intramuscular Karyotyping Male Medical sciences Penis - abnormalities Penis - drug effects Penis - growth & development Pharmacology. Drug treatments |
| title | Phallic Growth After hCG: A Clinical Index of Androgen Responsiveness |
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