The regulation of gene expression by insulin is differentially impaired in the liver of the genetically obese-hyperglycemic Wistar fatty rat

The regulation by insulin and carbohydrates of the gene expression of three key enzymes involved in glucose metabolism was studied in the liver of the Wistar fatty rat, a model of obese non-insulin-dependent diabetes mellitus. A high glucose or fructose diet, or insulin administration caused a simil...

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Veröffentlicht in:	FEBS letters 1993-08, Vol.328 (1), p.145-148
Hauptverfasser:	Noguchi, Tamio, Matsuda, Tamiko, Tomari, Yoshiaki, Yamada, Kazuya, Imai, Enyu, Wang, Ziyuan, Ikeda, Hitoshi, Tanaka, Takehiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Northern Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Enzymologic - drug effects GK, glucokinase Glucokinase Glucokinase - genetics Glucokinase - metabolism Insulin Insulin - pharmacology L-Type pyruvate kinase Liver - drug effects Liver - enzymology LPK, L-type pyruvate kinase Male Molecular and cellular biology Molecular genetics NIDDM, non-insulindependent diabetes mellitus Non-insulin-dependent diabetes mellitus PEPCK, phosphoenolpyruvate carboxykinase Phosphoenolpyruvate carboxykinase Phosphoenolpyruvate Carboxykinase (GTP) - genetics Phosphoenolpyruvate Carboxykinase (GTP) - metabolism Pyruvate Kinase - genetics Pyruvate Kinase - metabolism Rats Rats, Wistar RNA - isolation & purification RNA, Messenger - metabolism
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