Effects of physostigmine on septo-hippocampal averaged evoked field potentials
Field potentials were elicited in the CA3 field of freely-moving animals by paired-pulse stimulation of the ventral portion of the medial septum before and after exposure to physostigmine. Physosigmine had no effect on response components elicited by a single stimulus or by the first stimulus of a p...
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| Veröffentlicht in: | Brain research 1984-12, Vol.323 (1), p.148-153 |
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| creator | Hettinger, Matthew K. Gonzales, Larry P. |
| description | Field potentials were elicited in the CA3 field of freely-moving animals by paired-pulse stimulation of the ventral portion of the medial septum before and after exposure to physostigmine. Physosigmine had no effect on response components elicited by a single stimulus or by the first stimulus of a pulse pair. However, the amplitude of a late positive component elicited by the second stimulus of a pair was increased significantly following physostigmine. These results suggest that activity in a cholinergic portion of the septo-hippocampal pathway may serve to modulate the responsiveness of neurons in the CA3 field to subsequent stimulation. |
| doi_str_mv | 10.1016/0006-8993(84)90278-6 |
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Physosigmine had no effect on response components elicited by a single stimulus or by the first stimulus of a pulse pair. However, the amplitude of a late positive component elicited by the second stimulus of a pair was increased significantly following physostigmine. These results suggest that activity in a cholinergic portion of the septo-hippocampal pathway may serve to modulate the responsiveness of neurons in the CA3 field to subsequent stimulation.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(84)90278-6</identifier><identifier>PMID: 6098331</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Central nervous system ; Cholinergic Fibers - drug effects ; cholinergic projections ; Electrophysiology ; evoked potentials ; Evoked Potentials - drug effects ; Fundamental and applied biological sciences. Psychology ; hippocampus ; Hippocampus - drug effects ; In Vitro Techniques ; Male ; Neural Pathways - drug effects ; physostigmine ; Physostigmine - pharmacology ; Rats ; Rats, Inbred Strains ; septal nucleus ; septo-hippocampal pathway ; Septum Pellucidum - drug effects ; Synaptic Transmission - drug effects ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1984-12, Vol.323 (1), p.148-153</ispartof><rights>1984 Elsevier Science Publishers B.V.</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c366t-d4f63283c9e5bc7f81e10d632eeef6b78349d1c9f7e18596be9dee8558e968143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(84)90278-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8941992$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6098331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hettinger, Matthew K.</creatorcontrib><creatorcontrib>Gonzales, Larry P.</creatorcontrib><title>Effects of physostigmine on septo-hippocampal averaged evoked field potentials</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Field potentials were elicited in the CA3 field of freely-moving animals by paired-pulse stimulation of the ventral portion of the medial septum before and after exposure to physostigmine. Physosigmine had no effect on response components elicited by a single stimulus or by the first stimulus of a pulse pair. However, the amplitude of a late positive component elicited by the second stimulus of a pair was increased significantly following physostigmine. These results suggest that activity in a cholinergic portion of the septo-hippocampal pathway may serve to modulate the responsiveness of neurons in the CA3 field to subsequent stimulation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Cholinergic Fibers - drug effects</subject><subject>cholinergic projections</subject><subject>Electrophysiology</subject><subject>evoked potentials</subject><subject>Evoked Potentials - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Neural Pathways - drug effects</subject><subject>physostigmine</subject><subject>Physostigmine - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>septal nucleus</subject><subject>septo-hippocampal pathway</subject><subject>Septum Pellucidum - drug effects</subject><subject>Synaptic Transmission - drug effects</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpSTdp_kELPpSSHpxIliyPLoEQ8gWhuaRnoZVGiVrbciTvQv59tdllj-npZWaeGcQjQr4yesook2eUUlmDUvwExE9Fmw5q-YEsGHRNLRtBP5LFHvlMDnP-U0rOFT0gB5Iq4JwtyK8r79HOuYq-mp5fc8xzeBrCiFUcq4zTHOvnME3RmmEyfWXWmMwTugrX8W8JH7B31RRnHOdg-vyFfPIl8HiXR-T39dXj5W19_3Bzd3lxX1su5Vw74SVvgFuF7dJ2Hhgy6koLEb1cdsCFcswq3yGDVsklKocIbQuoJDDBj8iP7d0pxZcV5lkPIVvsezNiXGXdtQBCdfy_IBOUdQBtAcUWtCnmnNDrKYXBpFfNqN741huZeiNTg9BvvrUsa99291fLAd1-aSe4zL_v5iZb0_tkRhvyHgMlmFJNwc63GBZp64BJZxtwtOhCKt-jXQzvv-Mf5TScWQ</recordid><startdate>19841203</startdate><enddate>19841203</enddate><creator>Hettinger, Matthew K.</creator><creator>Gonzales, Larry P.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19841203</creationdate><title>Effects of physostigmine on septo-hippocampal averaged evoked field potentials</title><author>Hettinger, Matthew K. ; Gonzales, Larry P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-d4f63283c9e5bc7f81e10d632eeef6b78349d1c9f7e18596be9dee8558e968143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Cholinergic Fibers - drug effects</topic><topic>cholinergic projections</topic><topic>Electrophysiology</topic><topic>evoked potentials</topic><topic>Evoked Potentials - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Neural Pathways - drug effects</topic><topic>physostigmine</topic><topic>Physostigmine - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>septal nucleus</topic><topic>septo-hippocampal pathway</topic><topic>Septum Pellucidum - drug effects</topic><topic>Synaptic Transmission - drug effects</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hettinger, Matthew K.</creatorcontrib><creatorcontrib>Gonzales, Larry P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hettinger, Matthew K.</au><au>Gonzales, Larry P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of physostigmine on septo-hippocampal averaged evoked field potentials</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1984-12-03</date><risdate>1984</risdate><volume>323</volume><issue>1</issue><spage>148</spage><epage>153</epage><pages>148-153</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Field potentials were elicited in the CA3 field of freely-moving animals by paired-pulse stimulation of the ventral portion of the medial septum before and after exposure to physostigmine. Physosigmine had no effect on response components elicited by a single stimulus or by the first stimulus of a pulse pair. However, the amplitude of a late positive component elicited by the second stimulus of a pair was increased significantly following physostigmine. These results suggest that activity in a cholinergic portion of the septo-hippocampal pathway may serve to modulate the responsiveness of neurons in the CA3 field to subsequent stimulation.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>6098331</pmid><doi>10.1016/0006-8993(84)90278-6</doi><tpages>6</tpages></addata></record> |
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| ispartof | Brain research, 1984-12, Vol.323 (1), p.148-153 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences Central nervous system Cholinergic Fibers - drug effects cholinergic projections Electrophysiology evoked potentials Evoked Potentials - drug effects Fundamental and applied biological sciences. Psychology hippocampus Hippocampus - drug effects In Vitro Techniques Male Neural Pathways - drug effects physostigmine Physostigmine - pharmacology Rats Rats, Inbred Strains septal nucleus septo-hippocampal pathway Septum Pellucidum - drug effects Synaptic Transmission - drug effects Vertebrates: nervous system and sense organs |
| title | Effects of physostigmine on septo-hippocampal averaged evoked field potentials |
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