Hybridization and DNA sequence analyses suggest an early evolutionary divergence of related biosynthetic gene sets encoding polyketide antibiotics and spore pigments in Streptomyces spp

The whiE gene cluster of Streptomyces coelicolor, which is related to gene sets encoding the biosynthesis of polycyclic aromatic polyketide antibiotics, determines a spore pigment. Southern blotting using probes from three different parts of the whiE cluster revealed related gene sets in about half...

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Veröffentlicht in:	Gene 1993-08, Vol.130 (1), p.107-116
Hauptverfasser:	Blanco, G., Brianb, P., Pereda, A., Méndez, C., Salas, J.A., Chater, K.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Bacterial Agents - biosynthesis aromatic hydroxylase Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacteriology Base Sequence beta-Glucosidase - genetics Biological and medical sciences Biological Evolution Blotting, Southern Carrier Proteins - genetics condensing enzyme Conserved Sequence DNA Probes DNA, Bacterial - analysis Fatty Acids - biosynthesis Fundamental and applied biological sciences. Psychology Genes, Bacterial Genetics ketoreductase Microbiology Molecular phylogeny Molecular Sequence Data Multienzyme Complexes - genetics Multigene Family Open Reading Frames Oxidoreductases - genetics Peptides Pigments, Biological - chemistry Pigments, Biological - genetics secondary metabolism Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Spores, Bacterial - chemistry sporulation Streptococcus - enzymology Streptococcus - genetics Streptomyces coelicolor A3 Streptomyces halstedii β-glucosidase
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