Binding of drugs to human plasma proteins, exemplified by Sn(IV)-etiopurpurin dichloride delivered in cremophor and DMSO

1. 1. The mode-delivery-effect upon the binding of Sn(IV)-etiopurpurin dichloride (SnET2) in human plasma has been studied by ultracentrifugation, combined with absorption and fluorescence spectroscopy. SnET2 was delivered to plasma either in Cremophore EL (CRM) or in dimethyl sulfoxide (DMSO). To f...

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Veröffentlicht in:	International journal of biochemistry 1993-05, Vol.25 (5), p.739-760
Hauptverfasser:	Kongshaug, Magne, Moan, Johan, Long Sheng Cheng, Garbo, Greta M., Kolboe, Stein, Morgan, Alan R., Rimington, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Analytical, structural and metabolic biochemistry Biological and medical sciences Blood Proteins - metabolism Dimethyl Sulfoxide Fundamental and applied biological sciences. Psychology Humans Lipoproteins, HDL - metabolism Lipoproteins, LDL - metabolism Lipoproteins, VLDL - metabolism Pharmaceutical Vehicles Polyethylene Glycols Porphyrins - blood Porphyrins - metabolism Protein Binding Proteins Solvents
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