Manganese induces the overexpression of α-synuclein in PC12 cells via ERK activation

Abstract Manganese has been known to induce neurological disorders. In the present study, we determined the effect of manganese on the expression of α-synuclein in PC12 cells and its role in manganese-induced cytotoxicity. We also investigated the relationship between α-synuclein expression and the...

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Veröffentlicht in:	Brain research 2010-11, Vol.1359, p.201-207
Hauptverfasser:	Cai, Tongjian, Yao, Ting, Zheng, Gang, Chen, Yaoming, Du, Kejun, Cao, Yunxin, Shen, Xuefeng, Chen, Jingyuan, Luo, Wenjing
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - biosynthesis Animals Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Blotting, Western Cell Separation Enzyme Activation - drug effects ERK1/2 MAPK Extracellular Signal-Regulated MAP Kinases - drug effects Extracellular Signal-Regulated MAP Kinases - metabolism Flow Cytometry Manganese Manganese - toxicity Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology PC12 cell PC12 Cells Rats RNA Interference Signal Transduction - drug effects Signal Transduction - physiology Trace Elements - toxicity α-Synuclein
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