Plasma Cytokines and Portopulmonary Hypertension in Patients With Cirrhosis Waiting for Orthotopic Liver Transplantation
Portopulmonary hypertension (PPHTN) is a rare complication in patients with portal hypertension. A role of endothelin 1 (ET-1) and other cytokines was demonstrated in primary pulmonary hypertension but not in PPHTN. We evaluated the possible role of ET-1, interleukin 6 (IL-6), interleukin 1β (IL-1β)...
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| Veröffentlicht in: | Angiology 2010-11, Vol.61 (8), p.802-806 |
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| creator | Pellicelli, Adriano M. Barbaro, Giuseppe Puoti, Claudio Guarascio, Paolo Lusi, Elena Angela Bellis, Lia D'Ambrosio, Cecilia Villani, Roberto Vennarecci, Giovanni Liotta, Gianluca Ettore, Giuseppe Andreoli, Arnaldo |
| description | Portopulmonary hypertension (PPHTN) is a rare complication in patients with portal hypertension. A role of endothelin 1 (ET-1) and other cytokines was demonstrated in primary pulmonary hypertension but not in PPHTN. We evaluated the possible role of ET-1, interleukin 6 (IL-6), interleukin 1β (IL-1β), and tumor necrosis factor alpha (TNF-α) in the pathogenesis of PPHTN. Plasmatic concentrations of ET-1, IL-6, IL-1β, and TNF-α were measured in patients with pulmonary systolic arterial pressure (PAPs) >30 mm Hg and in patients with cirrhosis. In all, Six out of 11 patients with PAPs >30 mm Hg had PPHTN on right heart catheterization. The remaining 10 patients had an hyperdynamic circulation (HC). In PPHTN patients, ET-1 and IL-6 were significantly higher compared with HC and patients with cirrhosis. Endothelin 1 and IL-6 could be implicated in the pathogenesis of PPHTN. On the basis of these results, ET-1 receptor antagonists or anti-IL-6 could have a rationale in the treatment of PPHTN. |
| doi_str_mv | 10.1177/0003319710369101 |
| format | Article |
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A role of endothelin 1 (ET-1) and other cytokines was demonstrated in primary pulmonary hypertension but not in PPHTN. We evaluated the possible role of ET-1, interleukin 6 (IL-6), interleukin 1β (IL-1β), and tumor necrosis factor alpha (TNF-α) in the pathogenesis of PPHTN. Plasmatic concentrations of ET-1, IL-6, IL-1β, and TNF-α were measured in patients with pulmonary systolic arterial pressure (PAPs) >30 mm Hg and in patients with cirrhosis. In all, Six out of 11 patients with PAPs >30 mm Hg had PPHTN on right heart catheterization. The remaining 10 patients had an hyperdynamic circulation (HC). In PPHTN patients, ET-1 and IL-6 were significantly higher compared with HC and patients with cirrhosis. Endothelin 1 and IL-6 could be implicated in the pathogenesis of PPHTN. On the basis of these results, ET-1 receptor antagonists or anti-IL-6 could have a rationale in the treatment of PPHTN.</description><identifier>ISSN: 0003-3197</identifier><identifier>EISSN: 1940-1574</identifier><identifier>DOI: 10.1177/0003319710369101</identifier><identifier>PMID: 20498147</identifier><identifier>CODEN: ANGIAB</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Antagonists ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiac Catheterization ; Cardiology. Vascular system ; Coronary heart disease ; Cytokines - blood ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Echocardiography, Doppler, Color ; Endothelin-1 - blood ; Heart ; Humans ; Hypertension, Portal - blood ; Hypertension, Portal - complications ; Hypertension, Portal - diagnostic imaging ; Hypertension, Pulmonary - blood ; Hypertension, Pulmonary - complications ; Hypertension, Pulmonary - diagnosis ; Hypertension, Pulmonary - physiopathology ; Interleukin-1beta - blood ; Interleukin-6 - blood ; Liver Cirrhosis - blood ; Liver Cirrhosis - surgery ; Liver Transplantation ; Medical sciences ; Middle Aged ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Angiology, 2010-11, Vol.61 (8), p.802-806</ispartof><rights>The Author(s) 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-5d7d89a34e73319d93023dff0c6940dbe92ec134dbafa510847e000269814a0f3</citedby><cites>FETCH-LOGICAL-c399t-5d7d89a34e73319d93023dff0c6940dbe92ec134dbafa510847e000269814a0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0003319710369101$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0003319710369101$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23412781$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20498147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pellicelli, Adriano M.</creatorcontrib><creatorcontrib>Barbaro, Giuseppe</creatorcontrib><creatorcontrib>Puoti, Claudio</creatorcontrib><creatorcontrib>Guarascio, Paolo</creatorcontrib><creatorcontrib>Lusi, Elena Angela</creatorcontrib><creatorcontrib>Bellis, Lia</creatorcontrib><creatorcontrib>D'Ambrosio, Cecilia</creatorcontrib><creatorcontrib>Villani, Roberto</creatorcontrib><creatorcontrib>Vennarecci, Giovanni</creatorcontrib><creatorcontrib>Liotta, Gianluca</creatorcontrib><creatorcontrib>Ettore, Giuseppe</creatorcontrib><creatorcontrib>Andreoli, Arnaldo</creatorcontrib><title>Plasma Cytokines and Portopulmonary Hypertension in Patients With Cirrhosis Waiting for Orthotopic Liver Transplantation</title><title>Angiology</title><addtitle>Angiology</addtitle><description>Portopulmonary hypertension (PPHTN) is a rare complication in patients with portal hypertension. A role of endothelin 1 (ET-1) and other cytokines was demonstrated in primary pulmonary hypertension but not in PPHTN. We evaluated the possible role of ET-1, interleukin 6 (IL-6), interleukin 1β (IL-1β), and tumor necrosis factor alpha (TNF-α) in the pathogenesis of PPHTN. Plasmatic concentrations of ET-1, IL-6, IL-1β, and TNF-α were measured in patients with pulmonary systolic arterial pressure (PAPs) >30 mm Hg and in patients with cirrhosis. In all, Six out of 11 patients with PAPs >30 mm Hg had PPHTN on right heart catheterization. The remaining 10 patients had an hyperdynamic circulation (HC). In PPHTN patients, ET-1 and IL-6 were significantly higher compared with HC and patients with cirrhosis. Endothelin 1 and IL-6 could be implicated in the pathogenesis of PPHTN. 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Miscellaneous</subject><subject>Echocardiography, Doppler, Color</subject><subject>Endothelin-1 - blood</subject><subject>Heart</subject><subject>Humans</subject><subject>Hypertension, Portal - blood</subject><subject>Hypertension, Portal - complications</subject><subject>Hypertension, Portal - diagnostic imaging</subject><subject>Hypertension, Pulmonary - blood</subject><subject>Hypertension, Pulmonary - complications</subject><subject>Hypertension, Pulmonary - diagnosis</subject><subject>Hypertension, Pulmonary - physiopathology</subject><subject>Interleukin-1beta - blood</subject><subject>Interleukin-6 - blood</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - surgery</subject><subject>Liver Transplantation</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>0003-3197</issn><issn>1940-1574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFr2zAUxsVoWdJs952KLqW9uJUs2bKOI6zNIJAcUnY0ii0nSm3J05NH899PJtkGg_YkHu_3Pr3vewh9oeSeUiEeCCGMUSkoYbmkhH5AUyo5SWgm-AWaju1k7E_QFcAhlhkl-Uc0SQmXBeViil7XrYJO4fkxuBdjNWBla7x2Prh-aDtnlT_ixbHXPmgLxllsLF6rYLQNgH-YsMdz4_3egYmlMsHYHW6cxysf9i6KmAovzS_t8cYrC32rbIjTzn5Cl41qQX8-vzP0_PhtM18ky9XT9_nXZVIxKUOS1aIupGJci9FpLRlJWd00pMqj0XqrZaoryni9VY2K7goudPSZ5qM_RRo2Q7cn3d67n4OGUHYGKt3GRbQboBRZUTCRUhbJu3dJynOeEcFiqDNETmjlHYDXTdl708WoSkrK8TLl_5eJI9dn9WHb6frvwJ9TRODmDCioVNvEuCoD_zjGaSqKUSg5caB2ujy4wduY39sf_wa346OY</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Pellicelli, Adriano M.</creator><creator>Barbaro, Giuseppe</creator><creator>Puoti, Claudio</creator><creator>Guarascio, Paolo</creator><creator>Lusi, Elena Angela</creator><creator>Bellis, Lia</creator><creator>D'Ambrosio, Cecilia</creator><creator>Villani, Roberto</creator><creator>Vennarecci, Giovanni</creator><creator>Liotta, Gianluca</creator><creator>Ettore, Giuseppe</creator><creator>Andreoli, Arnaldo</creator><general>SAGE Publications</general><general>Sage Publications</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20101101</creationdate><title>Plasma Cytokines and Portopulmonary Hypertension in Patients With Cirrhosis Waiting for Orthotopic Liver Transplantation</title><author>Pellicelli, Adriano M. ; Barbaro, Giuseppe ; Puoti, Claudio ; Guarascio, Paolo ; Lusi, Elena Angela ; Bellis, Lia ; D'Ambrosio, Cecilia ; Villani, Roberto ; Vennarecci, Giovanni ; Liotta, Gianluca ; Ettore, Giuseppe ; Andreoli, Arnaldo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-5d7d89a34e73319d93023dff0c6940dbe92ec134dbafa510847e000269814a0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antagonists</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiac Catheterization</topic><topic>Cardiology. Vascular system</topic><topic>Coronary heart disease</topic><topic>Cytokines - blood</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. 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A role of endothelin 1 (ET-1) and other cytokines was demonstrated in primary pulmonary hypertension but not in PPHTN. We evaluated the possible role of ET-1, interleukin 6 (IL-6), interleukin 1β (IL-1β), and tumor necrosis factor alpha (TNF-α) in the pathogenesis of PPHTN. Plasmatic concentrations of ET-1, IL-6, IL-1β, and TNF-α were measured in patients with pulmonary systolic arterial pressure (PAPs) >30 mm Hg and in patients with cirrhosis. In all, Six out of 11 patients with PAPs >30 mm Hg had PPHTN on right heart catheterization. The remaining 10 patients had an hyperdynamic circulation (HC). In PPHTN patients, ET-1 and IL-6 were significantly higher compared with HC and patients with cirrhosis. Endothelin 1 and IL-6 could be implicated in the pathogenesis of PPHTN. On the basis of these results, ET-1 receptor antagonists or anti-IL-6 could have a rationale in the treatment of PPHTN.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>20498147</pmid><doi>10.1177/0003319710369101</doi><tpages>5</tpages></addata></record> |
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| subjects | Antagonists Biological and medical sciences Blood and lymphatic vessels Cardiac Catheterization Cardiology. Vascular system Coronary heart disease Cytokines - blood Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Echocardiography, Doppler, Color Endothelin-1 - blood Heart Humans Hypertension, Portal - blood Hypertension, Portal - complications Hypertension, Portal - diagnostic imaging Hypertension, Pulmonary - blood Hypertension, Pulmonary - complications Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - physiopathology Interleukin-1beta - blood Interleukin-6 - blood Liver Cirrhosis - blood Liver Cirrhosis - surgery Liver Transplantation Medical sciences Middle Aged Tumor Necrosis Factor-alpha - blood |
| title | Plasma Cytokines and Portopulmonary Hypertension in Patients With Cirrhosis Waiting for Orthotopic Liver Transplantation |
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