GSK4112, a Small Molecule Chemical Probe for the Cell Biology of the Nuclear Heme Receptor Rev-erbα

The identification of nonporphyrin ligands for the orphan nuclear receptor Rev-erbα will enable studies of its role as a heme sensor and regulator of metabolic and circadian signaling. We describe the development of a biochemical assay measuring the interaction between Rev-erbα and a peptide from th...

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Veröffentlicht in:	ACS chemical biology 2010-10, Vol.5 (10), p.925-932
Hauptverfasser:	Grant, Daniel, Yin, Lei, Collins, Jon L, Parks, Derek J, Orband-Miller, Lisa A, Wisely, G. Bruce, Joshi, Shree, Lazar, Mitchell A, Willson, Timothy M, Zuercher, William J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding, Competitive Cell Line Cells, Cultured Circadian Rhythm Glycine - analogs & derivatives Glycine - chemistry Glycine - metabolism Heme - metabolism Hepatocytes - metabolism Humans Male Mice Mice, Inbred C57BL Molecular Sequence Data Nuclear Receptor Co-Repressor 1 - chemistry Nuclear Receptor Co-Repressor 1 - metabolism Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism Peptides - chemistry Peptides - metabolism Protein Interaction Mapping - methods Small Molecule Libraries - chemistry Small Molecule Libraries - metabolism Thiophenes - chemistry Thiophenes - metabolism
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