Acute toxicity profile of radiotherapy in 690 children and adolescents: RiSK data
Abstract Background and purpose The “Registry for the evaluation of side effects after radiation in childhood and adolescence” (risk) was introduced to characterize adverse effects of radiotherapy in childhood and adolescence prospectively. The aim of this analysis was to characterize the pattern of...
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| Veröffentlicht in: | Radiotherapy and oncology 2010-10, Vol.97 (1), p.119-126 |
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| creator | Selo, Nadja Bölling, Tobias Ernst, Iris Pape, Hildegard Martini, Carmen Rübe, Christian Timmermann, Beate Fischedick, Karin Kortmann, Rolf-Dieter Gerß, Joachim Koch, Raphael Willich, Normann |
| description | Abstract Background and purpose The “Registry for the evaluation of side effects after radiation in childhood and adolescence” (risk) was introduced to characterize adverse effects of radiotherapy in childhood and adolescence prospectively. The aim of this analysis was to characterize the pattern of acute side effects. Materials and methods Since 2001, patients receiving radiotherapy in one of the German pediatric therapy trials have been registered in RiSK with detailed information regarding radiation doses to organs at risk and characterization of acute toxicities. Results From 2001 to May 2009, 690 patients have been characterized for acute toxicity in primary therapy. Acute toxicity ⩾ grade 1 was observed in 506 patients. In patients irradiated in their lung and liver, patients with grade 1 or 2 acute toxicities showed higher organ volumes exposed to radiation doses |
| doi_str_mv | 10.1016/j.radonc.2010.04.030 |
| format | Article |
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The aim of this analysis was to characterize the pattern of acute side effects. Materials and methods Since 2001, patients receiving radiotherapy in one of the German pediatric therapy trials have been registered in RiSK with detailed information regarding radiation doses to organs at risk and characterization of acute toxicities. Results From 2001 to May 2009, 690 patients have been characterized for acute toxicity in primary therapy. Acute toxicity ⩾ grade 1 was observed in 506 patients. In patients irradiated in their lung and liver, patients with grade 1 or 2 acute toxicities showed higher organ volumes exposed to radiation doses <20 Gray (Gy) compared to patients without toxicities. For the salivary glands, there was a positive correlation between the acute toxicity grade and the maximum radiation dose to the organ; the lower GI tract showed a similar trend. The impact of different chemotherapy regimens on these acute side effects remains unclear. Age did not have any impact on side effects. Conclusion This analysis gives a comprehensive overview of the acute toxicities of radiotherapy in children and adolescents. With prolongation of follow-up, detailed analyses regarding late toxicities will be possible with the characterization of dose–volume–effect relationships.</description><identifier>ISSN: 0167-8140</identifier><identifier>EISSN: 1879-0887</identifier><identifier>DOI: 10.1016/j.radonc.2010.04.030</identifier><identifier>PMID: 20605649</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Acute toxicity ; Adolescent ; Adolescents ; Child ; Children ; Female ; Germany ; Hematology, Oncology and Palliative Medicine ; Humans ; Male ; Neoplasms - radiotherapy ; Prospective Studies ; Radiation ; Radiation Injuries - radiotherapy ; Radiotherapy - adverse effects ; Radiotherapy Dosage ; Registries ; Risk Assessment ; Statistics, Nonparametric</subject><ispartof>Radiotherapy and oncology, 2010-10, Vol.97 (1), p.119-126</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2010 Elsevier Ireland Ltd</rights><rights>Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-2c8c7487c661960e5199f40a582e666931bb3ede074f3405806aa6de1d8a65713</citedby><cites>FETCH-LOGICAL-c416t-2c8c7487c661960e5199f40a582e666931bb3ede074f3405806aa6de1d8a65713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167814010002860$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20605649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Selo, Nadja</creatorcontrib><creatorcontrib>Bölling, Tobias</creatorcontrib><creatorcontrib>Ernst, Iris</creatorcontrib><creatorcontrib>Pape, Hildegard</creatorcontrib><creatorcontrib>Martini, Carmen</creatorcontrib><creatorcontrib>Rübe, Christian</creatorcontrib><creatorcontrib>Timmermann, Beate</creatorcontrib><creatorcontrib>Fischedick, Karin</creatorcontrib><creatorcontrib>Kortmann, Rolf-Dieter</creatorcontrib><creatorcontrib>Gerß, Joachim</creatorcontrib><creatorcontrib>Koch, Raphael</creatorcontrib><creatorcontrib>Willich, Normann</creatorcontrib><title>Acute toxicity profile of radiotherapy in 690 children and adolescents: RiSK data</title><title>Radiotherapy and oncology</title><addtitle>Radiother Oncol</addtitle><description>Abstract Background and purpose The “Registry for the evaluation of side effects after radiation in childhood and adolescence” (risk) was introduced to characterize adverse effects of radiotherapy in childhood and adolescence prospectively. The aim of this analysis was to characterize the pattern of acute side effects. Materials and methods Since 2001, patients receiving radiotherapy in one of the German pediatric therapy trials have been registered in RiSK with detailed information regarding radiation doses to organs at risk and characterization of acute toxicities. Results From 2001 to May 2009, 690 patients have been characterized for acute toxicity in primary therapy. Acute toxicity ⩾ grade 1 was observed in 506 patients. In patients irradiated in their lung and liver, patients with grade 1 or 2 acute toxicities showed higher organ volumes exposed to radiation doses <20 Gray (Gy) compared to patients without toxicities. For the salivary glands, there was a positive correlation between the acute toxicity grade and the maximum radiation dose to the organ; the lower GI tract showed a similar trend. The impact of different chemotherapy regimens on these acute side effects remains unclear. Age did not have any impact on side effects. Conclusion This analysis gives a comprehensive overview of the acute toxicities of radiotherapy in children and adolescents. With prolongation of follow-up, detailed analyses regarding late toxicities will be possible with the characterization of dose–volume–effect relationships.</description><subject>Acute toxicity</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Child</subject><subject>Children</subject><subject>Female</subject><subject>Germany</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Male</subject><subject>Neoplasms - radiotherapy</subject><subject>Prospective Studies</subject><subject>Radiation</subject><subject>Radiation Injuries - radiotherapy</subject><subject>Radiotherapy - adverse effects</subject><subject>Radiotherapy Dosage</subject><subject>Registries</subject><subject>Risk Assessment</subject><subject>Statistics, Nonparametric</subject><issn>0167-8140</issn><issn>1879-0887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EotvCP0DIN05ZxoljOxyQqgooaiXUFs6W156oXrL2YjsV--9xtIVDL5wsWW_em_keIW8YrBkw8X67TsbFYNct1C_ga-jgGVkxJYcGlJLPyarKZKMYhxNymvMWAFro5Ety0oKAXvBhRW7O7VyQlvjbW18OdJ_i6CekcaTV3sdyj8nsD9QHKgag9t5PLmGgJjha4yfMFkPJH-itv7uizhTzirwYzZTx9eN7Rn58_vT94rK5_vbl68X5dWM5E6VprbKSK2mFYIMA7NkwjBxMr1oUQgwd22w6dAiSjx2HXoEwRjhkThnRS9adkXdH37ryrxlz0Ttfl5kmEzDOWcteqTrI-6rkR6VNMeeEo94nvzPpoBnohaXe6iNLvbDUwHVlWcfePgbMmx26f0N_4VXBx6MA65kPHpPO1mOw6HxCW7SL_n8JTw3s5IO3ZvqJB8zbOKdQEWqmc6tB3y19LnWypUkloPsD442Z7A</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Selo, Nadja</creator><creator>Bölling, Tobias</creator><creator>Ernst, Iris</creator><creator>Pape, Hildegard</creator><creator>Martini, Carmen</creator><creator>Rübe, Christian</creator><creator>Timmermann, Beate</creator><creator>Fischedick, Karin</creator><creator>Kortmann, Rolf-Dieter</creator><creator>Gerß, Joachim</creator><creator>Koch, Raphael</creator><creator>Willich, Normann</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101001</creationdate><title>Acute toxicity profile of radiotherapy in 690 children and adolescents: RiSK data</title><author>Selo, Nadja ; Bölling, Tobias ; Ernst, Iris ; Pape, Hildegard ; Martini, Carmen ; Rübe, Christian ; Timmermann, Beate ; Fischedick, Karin ; Kortmann, Rolf-Dieter ; Gerß, Joachim ; Koch, Raphael ; Willich, Normann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-2c8c7487c661960e5199f40a582e666931bb3ede074f3405806aa6de1d8a65713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acute toxicity</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Child</topic><topic>Children</topic><topic>Female</topic><topic>Germany</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Male</topic><topic>Neoplasms - radiotherapy</topic><topic>Prospective Studies</topic><topic>Radiation</topic><topic>Radiation Injuries - radiotherapy</topic><topic>Radiotherapy - adverse effects</topic><topic>Radiotherapy Dosage</topic><topic>Registries</topic><topic>Risk Assessment</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Selo, Nadja</creatorcontrib><creatorcontrib>Bölling, Tobias</creatorcontrib><creatorcontrib>Ernst, Iris</creatorcontrib><creatorcontrib>Pape, Hildegard</creatorcontrib><creatorcontrib>Martini, Carmen</creatorcontrib><creatorcontrib>Rübe, Christian</creatorcontrib><creatorcontrib>Timmermann, Beate</creatorcontrib><creatorcontrib>Fischedick, Karin</creatorcontrib><creatorcontrib>Kortmann, Rolf-Dieter</creatorcontrib><creatorcontrib>Gerß, Joachim</creatorcontrib><creatorcontrib>Koch, Raphael</creatorcontrib><creatorcontrib>Willich, Normann</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiotherapy and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Selo, Nadja</au><au>Bölling, Tobias</au><au>Ernst, Iris</au><au>Pape, Hildegard</au><au>Martini, Carmen</au><au>Rübe, Christian</au><au>Timmermann, Beate</au><au>Fischedick, Karin</au><au>Kortmann, Rolf-Dieter</au><au>Gerß, Joachim</au><au>Koch, Raphael</au><au>Willich, Normann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute toxicity profile of radiotherapy in 690 children and adolescents: RiSK data</atitle><jtitle>Radiotherapy and oncology</jtitle><addtitle>Radiother Oncol</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>97</volume><issue>1</issue><spage>119</spage><epage>126</epage><pages>119-126</pages><issn>0167-8140</issn><eissn>1879-0887</eissn><abstract>Abstract Background and purpose The “Registry for the evaluation of side effects after radiation in childhood and adolescence” (risk) was introduced to characterize adverse effects of radiotherapy in childhood and adolescence prospectively. The aim of this analysis was to characterize the pattern of acute side effects. Materials and methods Since 2001, patients receiving radiotherapy in one of the German pediatric therapy trials have been registered in RiSK with detailed information regarding radiation doses to organs at risk and characterization of acute toxicities. Results From 2001 to May 2009, 690 patients have been characterized for acute toxicity in primary therapy. Acute toxicity ⩾ grade 1 was observed in 506 patients. In patients irradiated in their lung and liver, patients with grade 1 or 2 acute toxicities showed higher organ volumes exposed to radiation doses <20 Gray (Gy) compared to patients without toxicities. For the salivary glands, there was a positive correlation between the acute toxicity grade and the maximum radiation dose to the organ; the lower GI tract showed a similar trend. The impact of different chemotherapy regimens on these acute side effects remains unclear. Age did not have any impact on side effects. Conclusion This analysis gives a comprehensive overview of the acute toxicities of radiotherapy in children and adolescents. With prolongation of follow-up, detailed analyses regarding late toxicities will be possible with the characterization of dose–volume–effect relationships.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>20605649</pmid><doi>10.1016/j.radonc.2010.04.030</doi><tpages>8</tpages></addata></record> |
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| subjects | Acute toxicity Adolescent Adolescents Child Children Female Germany Hematology, Oncology and Palliative Medicine Humans Male Neoplasms - radiotherapy Prospective Studies Radiation Radiation Injuries - radiotherapy Radiotherapy - adverse effects Radiotherapy Dosage Registries Risk Assessment Statistics, Nonparametric |
| title | Acute toxicity profile of radiotherapy in 690 children and adolescents: RiSK data |
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