Interkeratin Peptide-Protein Interactions That Promote HPV16 E7 Gene Expression
Human papillomavirus (HPV) 16 E7 gene product encodes the major transforming activity of the virus so as to induce neoplastic transformation. Continued expression of HPV16 E7 protein is required for both the establishment and maintenance of the transformed cellular phenotype. Therefore, understandin...
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| Veröffentlicht in: | International journal of immunopathology and pharmacology 2010-07, Vol.23 (3), p.857-864 |
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| container_title | International journal of immunopathology and pharmacology |
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| creator | Lucchese, A. Serpico, R. Guida, A. Crincoli, V. Scully, C. Kanduc, D. |
| description | Human papillomavirus (HPV) 16 E7 gene product encodes the major transforming activity of the virus so as to induce neoplastic transformation. Continued expression of HPV16 E7 protein is required for both the establishment and maintenance of the transformed cellular phenotype. Therefore, understanding of the molecular and biochemical factors leading to the expression of E7 protein is important in relation to HPV-associated diseases. Previously, we identified a rare codon usage and a specific interaction between cytokeratin (CK) 7 and HPV16 E7 mRNA as factors modulating HPV16 E7 expression. In the present study we report that CK19, a biochemical marker of squamous oral and cervical cancer carcinogenesis, promotes the expression of HPV16 E7 oncoprotein by binding to the CK792–97SEQIKA peptide. These findings shed light on the dynamic functionality of the intermediate filament cytoskeleton, open new perspectives for investigating the role of CKs in controlling HPV16 E7 expression, and suggest new therapeutic avenues for HPV-associated carcinomas. |
| doi_str_mv | 10.1177/039463201002300321 |
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Continued expression of HPV16 E7 protein is required for both the establishment and maintenance of the transformed cellular phenotype. Therefore, understanding of the molecular and biochemical factors leading to the expression of E7 protein is important in relation to HPV-associated diseases. Previously, we identified a rare codon usage and a specific interaction between cytokeratin (CK) 7 and HPV16 E7 mRNA as factors modulating HPV16 E7 expression. In the present study we report that CK19, a biochemical marker of squamous oral and cervical cancer carcinogenesis, promotes the expression of HPV16 E7 oncoprotein by binding to the CK792–97SEQIKA peptide. These findings shed light on the dynamic functionality of the intermediate filament cytoskeleton, open new perspectives for investigating the role of CKs in controlling HPV16 E7 expression, and suggest new therapeutic avenues for HPV-associated carcinomas.</description><identifier>ISSN: 0394-6320</identifier><identifier>EISSN: 2058-7384</identifier><identifier>DOI: 10.1177/039463201002300321</identifier><identifier>PMID: 20943057</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>3T3 Cells ; Animals ; Biochemical markers ; Carcinogenesis ; Carcinoma ; Cell Line, Tumor ; Cervical cancer ; Cytokeratin ; Cytoskeleton ; double prime E7 gene ; E7 protein ; Electrophoretic Mobility Shift Assay ; Gene Expression Regulation, Viral - drug effects ; Human papillomavirus 16 ; Humans ; Intermediate filaments ; Keratins - chemistry ; Keratins - metabolism ; Keratins - pharmacology ; Mice ; Papillomavirus E7 Proteins - biosynthesis ; Papillomavirus E7 Proteins - genetics ; Protein Binding ; Protein Biosynthesis - drug effects ; Rabbits ; Reticulocytes - drug effects ; Reticulocytes - metabolism ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; RNA, Small Interfering ; Transfection ; Transformation</subject><ispartof>International journal of immunopathology and pharmacology, 2010-07, Vol.23 (3), p.857-864</ispartof><rights>2010 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-a4b3209e80c9710f796a08d54bff4dbe14b2ac222c16e7977792b5b90b26b10d3</citedby><cites>FETCH-LOGICAL-c419t-a4b3209e80c9710f796a08d54bff4dbe14b2ac222c16e7977792b5b90b26b10d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/039463201002300321$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/039463201002300321$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21945,27830,27901,27902,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/039463201002300321?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20943057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lucchese, A.</creatorcontrib><creatorcontrib>Serpico, R.</creatorcontrib><creatorcontrib>Guida, A.</creatorcontrib><creatorcontrib>Crincoli, V.</creatorcontrib><creatorcontrib>Scully, C.</creatorcontrib><creatorcontrib>Kanduc, D.</creatorcontrib><title>Interkeratin Peptide-Protein Interactions That Promote HPV16 E7 Gene Expression</title><title>International journal of immunopathology and pharmacology</title><addtitle>Int J Immunopathol Pharmacol</addtitle><description>Human papillomavirus (HPV) 16 E7 gene product encodes the major transforming activity of the virus so as to induce neoplastic transformation. Continued expression of HPV16 E7 protein is required for both the establishment and maintenance of the transformed cellular phenotype. Therefore, understanding of the molecular and biochemical factors leading to the expression of E7 protein is important in relation to HPV-associated diseases. Previously, we identified a rare codon usage and a specific interaction between cytokeratin (CK) 7 and HPV16 E7 mRNA as factors modulating HPV16 E7 expression. In the present study we report that CK19, a biochemical marker of squamous oral and cervical cancer carcinogenesis, promotes the expression of HPV16 E7 oncoprotein by binding to the CK792–97SEQIKA peptide. These findings shed light on the dynamic functionality of the intermediate filament cytoskeleton, open new perspectives for investigating the role of CKs in controlling HPV16 E7 expression, and suggest new therapeutic avenues for HPV-associated carcinomas.</description><subject>3T3 Cells</subject><subject>Animals</subject><subject>Biochemical markers</subject><subject>Carcinogenesis</subject><subject>Carcinoma</subject><subject>Cell Line, Tumor</subject><subject>Cervical cancer</subject><subject>Cytokeratin</subject><subject>Cytoskeleton</subject><subject>double prime E7 gene</subject><subject>E7 protein</subject><subject>Electrophoretic Mobility Shift Assay</subject><subject>Gene Expression Regulation, Viral - drug effects</subject><subject>Human papillomavirus 16</subject><subject>Humans</subject><subject>Intermediate filaments</subject><subject>Keratins - chemistry</subject><subject>Keratins - metabolism</subject><subject>Keratins - pharmacology</subject><subject>Mice</subject><subject>Papillomavirus E7 Proteins - biosynthesis</subject><subject>Papillomavirus E7 Proteins - genetics</subject><subject>Protein Binding</subject><subject>Protein Biosynthesis - drug effects</subject><subject>Rabbits</subject><subject>Reticulocytes - drug effects</subject><subject>Reticulocytes - metabolism</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Small Interfering</subject><subject>Transfection</subject><subject>Transformation</subject><issn>0394-6320</issn><issn>2058-7384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1Lw0AQBuBFFFtq_4AHyU0vsbMfyWaPUmpbKLSH6jXsJhNNbT7cTUD_vVurXoSeluF9ZlheQq4p3FMq5QS4EjFnQAEYB-CMnpEhgygJJU_EORkeQHgQAzJ2bgfgKRdRQi_JgIESHCI5JOtl3aF9Q6u7sg422HZljuHGNh36-TvUWVc2tQu2r7oLfFL5LFhsnmkczGQwxxqD2Udr0TnPrshFofcOxz_viDw9zrbTRbhaz5fTh1WYCaq6UAvjf6YwgUxJCoVUsYYkj4QpCpEbpMIwnTHGMhqjVFJKxUxkFBgWGwo5H5Hb493WNu89ui6tSpfhfq9rbHqXyihJOI-V8vLupKRABSjFIPGUHWlmG-csFmlry0rbT4_SQ-vp_9b90s3P_d5UmP-t_HbsweQInH7BdNf0tvbNnDr5Baw4h3c</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Lucchese, A.</creator><creator>Serpico, R.</creator><creator>Guida, A.</creator><creator>Crincoli, V.</creator><creator>Scully, C.</creator><creator>Kanduc, D.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20100701</creationdate><title>Interkeratin Peptide-Protein Interactions That Promote HPV16 E7 Gene Expression</title><author>Lucchese, A. ; 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| subjects | 3T3 Cells Animals Biochemical markers Carcinogenesis Carcinoma Cell Line, Tumor Cervical cancer Cytokeratin Cytoskeleton double prime E7 gene E7 protein Electrophoretic Mobility Shift Assay Gene Expression Regulation, Viral - drug effects Human papillomavirus 16 Humans Intermediate filaments Keratins - chemistry Keratins - metabolism Keratins - pharmacology Mice Papillomavirus E7 Proteins - biosynthesis Papillomavirus E7 Proteins - genetics Protein Binding Protein Biosynthesis - drug effects Rabbits Reticulocytes - drug effects Reticulocytes - metabolism RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Small Interfering Transfection Transformation |
| title | Interkeratin Peptide-Protein Interactions That Promote HPV16 E7 Gene Expression |
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